Mineralogy and chemistry of the green stone artifacts (muiraquitãs) of the museums of the Brazilian State of Pará

Os muiraquitãs foram considerados de proveniência asiática ou, também, como peças esculpidas pelas lendárias mulheres guerreiras, as Amazonas. São peças, hoje, muito raras, encontradas em alguns acervos de Museus. Estudos mineralógicos e químicos de 23 peças do acervo dos Museus de Gemas e do Encontro em Belém, Brasil, mostraram que os muiraquitãs podem ser constituídos, tanto de quartzo, como de albita, ou microclínio, pirofilita, variscita, anortita e tremolita (equivalente ao jade nefrítico), minerais frequentes em formações geológicas do Brasil. No entanto quatro peças são constituídas de jadeíta, ou seja, em jade jadeítico, raro e desconhecido na Amazônia e Brasil. A constatação da presença desse mineral reacende a discussão em torno da origem mineralógica dos muiraquitãs encontrados na Amazônia. Essa origem, antes da atual descoberta, era defendida como amazônica, devido à ausência de jade jadeítico nas peças pesquisadas e pelo fato de jadeíta não ter sido encontrada no Brasil, mas na América Central e na Ásia.

Multivariate Development and Validation of a Stability-Indicating HPLC Method for the Determination of Glimepiride in Tablets

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Quantification of Doxycycline Hyclate in Tablets by HPLC-UV Method

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A novel automated alternating current biosusceptometry method to characterization of controlled-release magnetic floating tablets of metronidazole

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Rolling Stone Brasil: aspectos de interatividade

The purpose of the present dissertation is to show the interactivity connections featured in a cultural journalism magazine's website through direct observation of its presented structure. The website chosen as object of study is Rolling Stone Brasil, April 2010 being the point of reference for analysis. Methodological support for such study has been culled from theoretical works on the principles that are necessary for the development of sampling in the observed structure. For this, are employed of concepts and strategies predicated by authors in the field of communications with emphasis on digital means is aplicated. The research indicates that the tools adopted in the website's structure comprise a potential of interactivity between the parties involved in the communication chain, and that the content therein produced may be considered as direct content of a web journalism structure

Imprensa alternativa e contracultura: o jornal brasileiro Rolling Stone de 1972

The present monograph is a historical research of one of the brazilian newspapers in a journalistic heterogeneous effervescence, referring to the proliferation of vehicles on alternative libertarians of the 60/70. The project gives visibility to the Rolling Stone newspaper as the document that disproved their own relevancy in the viability of the music production and counterculture inspired by North America, developing the repercussion of the new behavior of young flower power in the country. The personality of those who were in the journalistic team, the production schema, editorial and proposed tariffs would be in total congruency with the countercultural movement

Ergonomia de tablets em uso ocupacional: atividade visual e biomecânica postural sob a influência de ofuscamentos reflexivos causados pela iluminação

Pós-graduação em Design - FAAC

Use of the probability of stone formation (PSF) score to assess stone forming risk and treatment response in a cohort of Brazilian stone formers

Introduction: The aim was to confirm that PSF (probability of stone formation) changed appropriately following medical therapy on recurrent stone formers.Materials and Methods: Data were collected on 26 Brazilian stone-formers. A baseline 24-hour urine collection was performed prior to treatment. Details of the medical treatment initiated for stone-disease were recorded. A PSF calculation was performed on the 24 hour urine sample using the 7 urinary parameters required: voided volume, oxalate, calcium, urate, pH, citrate and magnesium. A repeat 24-hour urine sample was performed for PSF calculation after treatment. Comparison was made between the PSF scores before and during treatment.Results: At baseline, 20 of the 26 patients (77%) had a high PSF score (> 0.5). Of the 26 patients, 17 (65%) showed an overall reduction in their PSF profiles with a medical treatment regimen. Eleven patients (42%) changed from a high risk (PSF > 0.5) to a low risk (PSF < 0.5) and 6 patients reduced their risk score but did not change risk category. Six (23%) patients remained in a high risk category (> 0.5) during both assessments.Conclusions: The PSF score reduced following medical treatment in the majority of patients in this cohort.

Disintegration of magnetic tablets in human stomach evaluated by alternate current biosusceptometry

Oral administration is the most convenient route for drug therapy. The knowledge of the gastrointestinal transit and specific site for drug delivery is a prerequisite for development of dosage forms. The aim of this work was to demonstrate that is possible to monitor the disintegration process of film-coated magnetic tablets by multi-sensor alternate current Biosusceptometry (ACB) in vivo and in vitro. This method is based on the recording of signals produced by the magnetic tablet using a seven sensors array and signal-processing techniques. The disintegration was confirmed by signals analysis in healthy human volunteers' measurements and in vitro experiments. Results showed that ACB is efficient to characterize the disintegration of dosage forms in the stomach, being a research tool for the development of new pharmaceutical dosage forms.

Revista Rolling Stone Brasil: em busca do perfil ideal do leitor do site

O presente trabalho tem por objetivo buscar características que ajudem a definir quem é o público leitor do site da Rolling Stone Brasil, levantando a questão da migração de revistas que surgiram antes da internet para o ciberespaço. Para isso, com base em revisão bibliográfica, retornamos na história para resgatar as origens da versão impressa da publicação e das origens do próprio jornalismo de revista. Com base em uma pesquisa sobre o que se chamou de Perfis Digigraficos e com realização de entrevistas com os editores do site e da revista Rolling Stone Brasil, concluímos que este perfil, aqui chamado de ideal, não está relacionado com idade, gênero e gosto musical

Development and validation of first derivative spectrophotometric method for quantification of darunavir in tablets

Aims: Darunavir is widely used in HIV/AIDS therapy. It is a HIV protease inhibitor that has excellent efficacy against the virus. The aim of this study is to develop and validate an analytical method fast and free of interferences for determination of darunavir ethanolate as raw material and tablet dosage form. Methodology: As the formulation excipients show high interference in darunavir determination by a direct UV absorption measurement a derivative spectrophotometry was applied. A selective, easy and fast method was achieved employing simple and cheap instrumentation by using first-order derivative spectrophotometry. Results: The first-derivation of spectrum of the drug measured between 200 and 400 nm allowed identification of the analyte and showed absence of placebo interference. The assay was based on the absorbance at 276nm. The linear concentration range was established from 11 to 21 μg/mL. The intra-day and inter-day precision expressed as RSD was 0.06% and 3.75% respectively with mean recovery of 99.84%. Conclusion: The proposed analytical method is able to quantify darunavir as raw material and tablets and can be used routinely by any laboratory applying a spectrophotometer with a derivative accessory. The great difference of the method proposed here is that it proves to be free of placebo interferences as well as simple, fast and low cost.

Stability study of darunavir ethanolate tablets applying a new stability-indicating HPLC method

Chemical and physical degradation of drugs may result in altered therapeutic efficacy and even toxic effects. Therefore, the aim of this work was to study the stability of darunavir and to develop and validate a liquid chromatography (LC) method to determine darunavir in raw material and tablets in the presence of degradation products. The novel method showed to be linear from 6.0 to 21.0 μg/mL, with high precision (CV < 2%) and accuracy (recuperation of 99.64%). It is simple and reliable, free of placebo interferences. The robustness of the method was evaluated by a factorial design using seven different parameters. Forced degradation study was done under alkaline, acidic, and oxidative stress at ambient temperature and by heating. The LC method was able to quantify and separate darunavir and its degradation products. Darunavir showed to be unstable under alkaline, acid, and oxidative conditions. The novelty of this study is understanding the factors that affect darunavir ethanolate stability in tablets, which is the first step to unravel the path to know the degradation products. The novel stability-indicating method can be used to monitor the drug and the main degradation products in low concentrations in which there is linearity.

Comparative study over methods developed for quantification of darunavir in tablets by environmental friendly infrared and capillary electrophoretic techniques

Darunavir, a protease inhibitor used in the treatment of HIV infection, presents few methods for its determination in pharmaceuticals. Infrared (IR) spectroscopy offers the possibility of obtaining spectra relatively quickly, providing interesting information, analytically, qualitatively or quantitatively. Capillary electrophoresis (CE) performs separations of high efficiency in shorter time with reagents and samples in small quantity. These two methods are cost-benefitted when we evaluate the green level and the cost of analysis. Faster and cheaper methods without generating organic waste by IR and CE for the quantification of darunavir were developed and validated, focusing socioeconomic impact of analytical decisions. If the cost of acquisition, maintenance, production, analysis and conditioning of drugs and pharmaceuticals is high, consequently the price of this product in the market will be higher and it cannot be accessible to the patient. Treatment failure not only affects the quality of life of patients, but also contributes significantly to the economic burden of the health system. In this context there is a tool called Analysis of the Life Cycle, which comes to make us think in a multidimensional way focusing the whole, the parts and especially the interaction among the parts of a system.

Development and validation of a stability-indicative turbidimetric assay to determine the potency of doxycycline hyclate in tablets

The doxycycline (DOX) is a broad-spectrum antibiotic used in several countries. This drug is part of the list of medicines to the SUS (Unified Health System), a model of health care in Brazil. This study describes the development and validation of a microbiological assay, applying the turbidimetric method for the determination of DOX, as well as the evaluation of the ability of the method in determining the stability of DOX in tablets against acidic and basic hydrolysis, photolytic and oxidative degradations, using Escherichia coli ATCC 10536 as micro-organism test and 3×3 parallel line assay design, with nine tubes for each assay, as recommended by the Brazilian Pharmacopoeia. The developed and validated method showed excellent results of linearity, selectivity, precision, accuracy and robustness. The assay is based on the inhibitory effect of DOX using Escherichia coli ATCC 10536. The results of the assay were treated by analysis of variance and were found to be linear (r= 0.9986) in the range from 4.0 to 9.0μg/mL, precise (repeatability R.S.D.= 0.99 and intermediate precision was confirmed by statistical analysis the mean values obtained from analysis by different analysts) and exact (97.73%). DOX solution exposed to direct UV light, alkaline and acid hydrolysis and hydrogen peroxide causing oxidation were used to evaluate the specificity of the bioassay. Comparison of bioassay and liquid chromatography showed differences in results between methodologies. The results showed that the bioassay is valid, simple and useful alternative methodology for DOX determination in routine quality control.