229 resultados para Rosalind Hackett
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Includes index.
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"Developed under contract to the State of California Agriculture and Services Agency through a grant from the U.S. Civil Service Commission under the Intergovernmental Personnel Act (P.L. 91-648)."--verso of t.p.
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<p><b>Top Row: </b>Abiola Akinwumi, Laura Ambrook, Becky Bail-Salamin, Charlotte Baker, Ronald A. Palas, Jodi Lynn Bamberg, Cindy Bauer, Kimberly Beal, Tina Bednarski-Lynch, Lisa Bennett, Kate Bergsma, Colleen Block, Caroline Bock, Karen Bogan, Michael J. Bologna</p><p><b>Row 2: </b>Julie Boyer, Wilma J. Branch, Stacey M. Quinn, Michelle Archambeau, Monica Patel, Stacey Doorn, Bryn Gerich, Bethany L. Tallon, Shannon Bason, Pete Jennings, Heather Cahill, Tamar Pleasant, Suzanne Shiller, Andrea Caldwell, Lisa Cook</p><p><b>Row 3: </b>Rebecca Cross, Karen Cuevas, Anissa Damrau, Sheila Davis, Stephanie Day, Vikki Dhingra, Laura Doan, Catherine Doud, Tanya L. Dudlay, Ruth Dunlap, Heather Elenbaas, Karie Erskine</p><p><b>Row 4: </b>Julie Everett, Anne Flunder, Melanie Frank, Alexandra Frederick, Michele Fronk, Jennifer garcia, Shamaine Gardner, Robin Gawrych, Celeste Gibson, Patricia Gilhooly, Erin Gill, Rosemary Goins</p><p><b>Row 5: </b>Tonya Grueschow, Christopher Hackett, Kathy Halabicky, Patricia Hanlon, Patricia Hansen, Violet Barkauskas, Beverly Jones, Ada Sue Hinshaw, Janice Lindberg, Nola Pender, Chris Harbough, Patricia Hawes, Laurie Hehne, Katherine Hendershot, Karin Hensley</p><p><b>Row 6: </b>Rebecca Hill, Jennifer Hofmeister, Laura Hurlbert, Carey-Anne Irwin, Elizabeth Jelsone, Jennifer Joscelyn, Keith Keller, Kimberly Killian, Jacqueline Klein, Suzanne Knight, Jennifer L. Knurr, Caroline Kolcheff, Jenna Konarzewski, Julie Kronk, Layla Lahuti, Ellen L. Lapinski</p><p><b>Row 7: </b>Eunice Lee, Jamie Leslie, Jennifer Lofquist, Judith A. Long, Lorelei Manly, Jennifer McEachern, Tamara McLaughlin, Keela McLin, Kelly Moody, Robin R. Moore, Nicole Nestler, colleen Nowicki, Carla Ogundipe, Christa O'Mar, Mychelle A. Overton, Kara Pacis, Vicki Partin</p><p><b>Row 8: </b>MaryAnn Poplawski, Nan Preston, Tiffany L. Raley, Jennifer Rebecca Raub, William Reau, Karen Reeder, Linda Rickard, Karen Salus, Laura Saraent, Darlene Scheper, Joanna Serman, Laura-Jean Siggens, Ann Marie Simonelli, Mary Skilton, Amy Stachowiak, Lorraine Stafford</p><p><b>Row 9: </b>Samantha Stallos, Monica Steplowski, Mary Swager, Victoria R. Taylor, Susan J. Ulman, Rene Urban, Sarah B. Vander Schaaf, Maria P. Vano, Tresa VerMeulen, James Voiland, Johanne C. Walter, Amy K. Warrow, Nicole Weidler, Benjamin Weisenfeld, Marie Wolfer, Marcy Yackish</p>
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Mode of access: Internet.
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Shipping list no.: 86-862-P.
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Cover title.
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Foreword signed Frederic G. Melcher.
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Thesis (Ph.D.)--University of Washington, 2016-06
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Defining the pharmacokinetics of drugs in overdose is complicated. Deliberate self-poisoning is generally impulsive and associated with poor accuracy in dose history. In addition, early blood samples are rarely collected to characterize the whole plasma-concentration time profile and the effect of decontamination on the pharmacokinetics is uncertain. The aim of this study was to explore a fully Bayesian methodology for population pharmacokinetic analysis of data that arose from deliberate self-poisoning with citalopram. Prior information on the pharmacokinetic parameters was elicited from 14 published studies on citalopram when taken in therapeutic doses. The data set included concentration-time data from 53 patients studied after 63 citalopram overdose events (dose range: 20-1700 mg). Activated charcoal was administered between 0.5 and 4 h after 17 overdose events. The clinical investigator graded the veracity of the patients' dosing history on a 5-point ordinal scale. Inclusion of informative priors stabilised the pharmacokinetic model and the population mean values could be estimated well. There were no indications of non-linear clearance after excessive doses. The final model included an estimated uncertainty of the dose amount which in a simulation study was shown to not affect the model's ability to characterise the effects of activated charcoal. The effect of activated charcoal on clearance and bioavailability was pronounced and resulted in a 72% increase and 22% decrease, respectively. These findings suggest charcoal administration is potentially beneficial after citalopram overdose. The methodology explored seems promising for exploring the dose-exposure relationship in the toxicological settings.
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To examine the effect of an algorithm-based sedation guideline developed in a North American intensive care unit (ICU) on the duration of mechanical ventilation of patients in an Australian ICU. The intervention was tested in a pre-intervention, post-intervention comparative investigation in a 14-bed adult intensive care unit. Adult mechanically ventilated patients were selected consecutively (n =322) The pre-intervention and post-intervention groups were similar except for a higher number of patients with a neurological diagnosis in the pre-intervention group. An algorithm-based sedation guideline including a sedation scale was introduced using a multifaceted implementation strategy. The median duration of ventilation was 5.6 days in the post-intervention group, compared with 4.8 days for the pre-intervention group (P = 0.99). The length of stay was 8.2 days in the post-intervention group versus 7.1 days in the pre-intervention group (P = 0.04). There were no statistically significant differences for the other secondary outcomes, including the score on the Experience of Treatment in ICU 7 item questionnaire, number of tracheostomies and number of self-extubations. Records of compliance to recording the sedation score during both phases revealed that patients were slightly more deeply sedated when the guideline was used. The use of the algorithm-based sedation guideline did not reduce duration of mechanical ventilation in the setting of this study.
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Diversity has become an important issue at all levels of the company from the boardroom to the back office. It is increasingly apparent that diversity is vital to productivity, with academic research indicating an important link between diverse top management team (TMT) composition and corporate performance. However, the nature of this link remains elusive, as there is little accessible research that can help top teams to evaluate how diversity impacts on their strategic capacity. This paper seeks to fill this gap by developing a conceptual framework, illustrated with case examples, to explain the relationships between TMT diversity and TMT collective action. As collective action is difficult to attain from top teams that are high in diversity, six practical processes are developed from this framework for establishing and exploiting top team strategic capacity. The paper concludes by outlining the theoretical implications of the framework. © Elsevier Ltd. All rights reserved.
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This article describes a study of the relationships between team inputs (task type and team size) and team processes in 87 cross industry Portuguese teams, some of which had high and some low requirements to innovate. Team processes were measured using the Team Climate Inventory (TCI), which focuses on clarity of and commitment to team objectives, levels of participation, support for innovation, and quality emphases. Three hypotheses were tested. The first proposed that teams carrying out tasks with a high innovation requirement would have high scores on a measure of team processes. This was supported insofar as such teams reported higher levels of participation and support for innovation. The second hypothesis proposed that large teams would have poorer team processes. This hypothesis was confirmed. The third hypothesis concerned the interaction between size and innovation. The results suggested that large teams operating under a relatively high pressure to innovate have poorer team processes than large teams that do not have a high requirement to innovate.
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Two forms of the growth hormone-releasing hormone (GHRH) receptor (GHRH-R) exist in terms of a polymorphism at codon 57. The most common allele possesses GCG, coding for Ala. This codon can also be ACG, replacing the Ala with Thr. The present study demonstrates that the latter occurs in about 20% of pituitary somatotrophinomas, removed from patients with acromegaly. Somatotrophinomas possessing the alternative allele respond, on average, more strongly to GHRH in terms of GH secretion in vitro than tumors which are homozygous for the more common allele. The distribution of the two allelic forms of the GHRH-R did not significantly differ between acromegalic and non-acromegalic subjects. Thus, while the alternative allelic forms may, at least partially, contribute to the variable response of serum GH levels to i.v. GHRH observed in acromegalic and normal subjects, it is unlikely that subjects possessing the rarer form containing Thr in place of Ala at residue 57 are at increased risk of developing acromegaly.