Paul Williams, nephew of C. C. Chapman, Fort Worth, Texas

Studio portrait of Paul Williams, nephew of C. C. Chapman, Fort Worth, Texas. He worked in Chapman's Fullerton office, 5th floor, N. Spadra Street [now Harbor Blvd.], Fullerton, California.

Étude chronologique sur la troisième guerre sacrée (356-346 avant J.C.) / par Paul Cloché. --

Bibliography: p. [vii]- viii .

Verlags-Katalog von J. C. B. Mohr (Paul Siebeck) in Tübingen, 1801 bis 1906 mit Nachtrag über das Jahr 1907.

Mode of access: Internet.

Voyage du sieur Paul Lucas, fait en M.DCC.XIV, &c. par ordre de Louis XIV. dans la Turquie, l'Asie, Sourie, Palestine, Haute & Basse Egypte, &c. ...

Added t.-p. has imprint: Rouen, Machuel, 1728.

De nieuwste ontdekkingen aan de westkust van Afrika : reistogten, jagtavonturen en handelsreizen van Paul du Chaillu in Midden-Afrika, van Ladislaus Magyar in Benguela en Bihe, en van C. Joh. Anderson nabij de rivier Okavango /

Mode of access: Internet.

Report of the d'Hauteville case: The commonwealth of Pennsylvania, at the suggestion of Paul Daniel Gonsalve Grand d'Hauteville, versus David Sears, Miriam C. Sears, and Ellen Sears Grand d'Hauteville. Habeas corpus for the custody of an infant child.

In the Court of general sessions for the city and county of Philadelphia. Habeas corpus for the custody of Frederick Sears Grand d'Hauteville.

A reply to two deistical works, entitled "The New Trial of the Witnesses," &c. and Gamaliel Smith's [pseud. for Jeremy Bentham] "Not Paul but Jesus."

Mode of access: Internet.

Nominations before the Senate Armed Services Committee, second session, 105th Congress : hearings before the Committee on Armed Services, United States Senate, One Hundred Fifth Congress, second session, on nominations of Gen. Joseph W. Ralston, David R. Oliver; Dr. Sue Bailey; Paul J. Hoeper; Dr. Hans Mark; Dr. Joseph W. Westphal; Mahlon Apgar IV; Louis E. Caldera; Daryl L. Jones; Gen. Richard B. Myers; Vice Adm. Richard W. Mies; Lt. Gen. Charles T. Butler DeMesme; James M. Bodner; Dennis C. Blair; Richard J. Danzig; Bernard D. Rostker; Stephen W. Preston; Herbert L. Buchanan III; Jeh C. Johnson, February 4, 5; March 17; June 2, 16, 23; July 16, 22, 23; September 15, 22, 1998.

Shipping list no.: 99-0207-P.

Conformations of platypus venom C-type natriuretic peptide in aqueous solution and sodium dodecyl sulfate micelles

Nuclear magnetic resonance spectroscopy was used to investigate the conformations of the platypus venom C-type natriuretic peptide A (OvCNPa) in aqueous solutions and in solutions containing sodium dodecyl sulfate (SDS) micelles. The chemically synthesized OvCNPa showed a substantial decrease in flexibility in aqueous solution at 10 degreesC, allowing the observation of medium- and long-range nuclear Overhauser enhancement (NOE) connectivities. Three-dimensional structures calculated using these data showed flexible and reasonably well-defined regions, the locations of which were similar in the two solvents. In aqueous solution, the linear part that spans residues 3-14 was basically an extended conformation while the cyclic portion, defined by residues 23-39, contained a series of beta-turns. The overall shape of the cyclic portion was similar to that observed for an atrial natriuretic peptide (ANP) variant in aqueous solution. OvCNPa adopted a different conformation in SDS micelles wherein the N-terminal region, defined by residues 2-10, was more compact, characterised by turns and a helix, while the cyclic region had turns and an overall shape that was fundamentally different from those structures observed in aqueous solution. The hydrophobic cluster, situated at the centre of the ring of the structure in aqueous solution, was absent in the structure in the presence of SDS micelles. Thus, OvCNPa interacts with SDS micelles and can possibly form ion-channels in cell membranes. (C) 2002 Elsevier Science Ltd. All rights reserved.

Spin states of C-60(3-) and C120On- (n=2, 3, 4) anions using electron spin transient nutation spectroscopy

Electron spin transient nutation (ESTN) experiments show that the spin multiplicity of the ground state of C-60(3-) in frozen solution is a doublet with S = 1/2. In purified samples, there is no evidence for excited states or other species with higher multiplicity. In the anions Of C120On- (n = 2, 3, 4), where the CW EPR experiments have shown that a mixture of species is present, ESTN experiments confirm that a doublet with S = 1/2 is associated with the 3- anion and triplets with S = 1 are associated with the 2- and 4- anions. A weak nutation peak attributable to m(s) = -1/2 1/2 transitions within a quartet state may arise from association of anions with spins of 1/2 and 1 in solute aggregates.

Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2

Primary murine fetal hemopoietic cells were transformed with a fusion protein consisting of the ligand-binding domain of the estrogen receptor and a carboxyl-terminally truncated c-Myb protein (ERMYB), The ERMYB-transformed hemopoietic cells exhibit an immature myeloid phenotype when grown in the presence of beta-estradiol. Upon removal of beta-estradiol, the ERMYB cells display increased adherence, decreased clonogenicity and differentiate to cells exhibiting granulocyte or macrophage morphology, The expression of the c-myc, c-kit, cdc2 and bcl-2 genes, which are putatively regulated by Myb, was investigated in ERMYB cells grown in the presence or absence of beta-estradiol. Neither c-myc nor cdc2 expression was down-regulated after removal of beta-estradiol demonstrating that differentiation is not a consequence of decreased transactivation of these genes by ERMYB. While bcl-2 expression was reduced by 50% in ERMYB cells grown in the absence of beta-estradiol, there was no increase in DNA laddering, suggesting that Myb was not protecting ERMYB cells from apoptosis, In contrast, a substantial (200-fold) decrease in c-kit mRNA level was observed following differentiation of ERMYB cells, and c-kit mRNA could be partially re-induced by the re-addition of beta-estradiol. Furthermore, a reporter construct containing the c-kit promoter was activated when cotransfected with a Myb expression vector, providing further evidence of a role for Myb in the regulation of c-kit.

Molecular basis of infantile reversible cytochrome c oxidase deficiency myopathy

Childhood-onset mitochondrial encephalomyopathies are usually severe, relentlessly progressive conditions that have a fatal outcome. However, a puzzling infantile disorder, long known as `benign cytochrome c oxidase deficiency myopathy` is an exception because it shows spontaneous recovery if infants survive the first months of life. Current investigations cannot distinguish those with a good prognosis from those with terminal disease, making it very difficult to decide when to continue intensive supportive care. Here we define the principal molecular basis of the disorder by identifying a maternally inherited, homoplasmic m.14674T > C mt-tRNA(Glu) mutation in 17 patients from 12 families. Our results provide functional evidence for the pathogenicity of the mutation and show that tissue-specific mechanisms downstream of tRNA(Glu) may explain the spontaneous recovery. This study provides the rationale for a simple genetic test to identify infants with mitochondrial myopathy and good prognosis.