Juegos de niños : concierto didáctico para piano a cuatro manos y narración.

Resumen tomado de la publicación

Ume-jolasak : kontzertu didaktikoa pianoarentzat lau eskuez jotzekoa eta narrazioa. 'Juegos de niños : concierto didáctico para piano a cuatro manos y narración'.

Resumen tomado de la publicación

Cartas a Clara : concierto didáctico para alumnos de educación secundaria : espectáculo musical para orquesta, piano y narrador.

Resumen tomado de la publicación

Klarari Gutunak : bigarren hezkuntzako ikasleentzako kontzertu didaktikoa : musika ikuskizuna orkestra, piano eta narratzailerako. 'Cartas a Clara : concierto didáctico para alumnos de educación secundaria : espectáculo musical para orquesta, piano y narrador'.

Resumen tomado de la publicación

Concepciones de profesores de piano sobre la evaluación.

Resumen basado en el de la publicación

Programación de la música contemporánea en los estudios de piano.

Se adjunta a la memoria el trabajo de investigación propiamente dicho que es el que figura en el enlace.

Piano complementario en el Grado Superior.

Resumen tomado de la publicación. La publicación recoge resumen en inglés

The gut microbiota: a major player in the toxicity of environmental pollutants?

Exposure to environmental chemicals has been linked to various health disorders, including obesity, type 2 diabetes, cancer and dysregulation of the immune and reproductive systems, whereas the gastrointestinal microbiota critically contributes to a variety of host metabolic and immune functions. We aimed to evaluate the bidirectional relationship between gut bacteria and environmental pollutants and to assess the toxicological relevance of the bacteria–xenobiotic interplay for the host. We examined studies using isolated bacteria, faecal or caecal suspensions—germ-free or antibiotic-treated animals—as well as animals reassociated with a microbiota exposed to environmental chemicals. The literature indicates that gut microbes have an extensive capacity to metabolise environmental chemicals that can be classified in five core enzymatic families (azoreductases, nitroreductases, β-glucuronidases, sulfatases and β-lyases) unequivocally involved in the metabolism of >30 environmental contaminants. There is clear evidence that bacteria-dependent metabolism of pollutants modulates the toxicity for the host. Conversely, environmental contaminants from various chemical families have been shown to alter the composition and/or the metabolic activity of the gastrointestinal bacteria, which may be an important factor contributing to shape an individual’s microbiotype. The physiological consequences of these alterations have not been studied in details but pollutant-induced alterations of the gut bacteria are likely to contribute to their toxicity. In conclusion, there is a body of evidence suggesting that gut microbiota are a major, yet underestimated element that must be considered to fully evaluate the toxicity of environmental contaminants.

Leptin and the Immune Response An Active Player or an Innocent Bystander?

Leptin is involved in the control of energy storage by the body. Low serum leptin levels, as seen in starvation, are associated with impaired inflammatory T cell responses that can be reversed by exogenous leptin. Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and recurrent infections. Several defects in T cell function have also been described, and allergy, autoimmune disease, and lymphomas or other malignancies can be present. Previous studies in Brazilian CVID patients have shown that, in contrast with mononuclear cells from healthy controls, CVID cells cultured with phytohemagglutinin and added leptin increased the proliferative response and decreased activation-induced apoptosis. Interleukin (IL)-2 and especially IL-4 production also increased significantly, although the effects of exposure to leptin were not observed uniformly in CVID patients. The majority, however, responded in some degree, and some exhibited completely restored values of the four parameters. These remarkable results indicate leptin could be used to improve immune function in these patients. On the other hand, we found no specific correlation between serum leptin levels and the number of infectious events over a 24-month period, presence of autoimmunity, allergies, or cancer in these patients. The results suggest that the absolute value of serum leptin does not determine the clinical behavior of patients or responses to leptin in vitro. Of note is the divergence between serum leptin, response to leptin in vitro, and the presence of autoimmunity, indicating the need to identify the cellular and molecular players involved in the regulation of the immune response by leptin in CVID.

Piano Crafts Department

Students are shown working on pianos in various states of construction in the Piano Crafts Department at the New York Trade School. Black and white photograph.

Piano Tuning Classroom

A Wissner piano is shown in a piano tuning classroom at the New York Trade School. Wissner pianos were manufactured in Brooklyn from 1878 until the company went out of business at the start of World War II. Black and white photograph.

Students working in Piano Crafts Department

Three students are shown working in the Piano Crafts Department at the New York Trade School. The two students in the foreground appear to be working on the construction of a piano. Black and white photograph.