Pattern of cytokine and chemokine production by THP-1 derived macrophages in response to live or heat-killed Mycobacterium bovis bacillus Calmette-Guérin Moreau strain

Tuberculosis has great public health impact with high rates of mortality and the only prophylactic measure for it is the Mycobacterium bovisbacillus Calmette-Guérin (BCG) vaccine. The present study evaluated the release of cytokines [interleukin (IL)-1, tumour necrosis factor and IL-6] and chemokines [macrophage inflammatory protein (MIP)-1α and MIP-1β] by THP-1 derived macrophages infected with BCG vaccine obtained by growing mycobacteria in Viscondessa de Moraes Institute medium medium (oral) or Sauton medium (intradermic) to compare the effects of live and heat-killed (HK) mycobacteria. Because BCG has been reported to lose viability during the lyophilisation process and during storage, we examined whether exposing BCG to different temperatures also triggers differences in the expression of some important cytokines and chemokines of the immune response. Interestingly, we observed that HK mycobacteria stimulated cytokine and chemokine production in a different pattern from that observed with live mycobacteria.

Soissons, cloître de [l'abbaye] St-Jean-des-Vignes [dégâts dus à la guerre] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55109

10-8-19, Colombes, arrivée du championnat de france du 800 m [Jean Vermeulen vainqueur] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55412

Aveux baillés à Jean de Saillant par ses vassaux, en 1484 et années suivantes.

Acquis le 9 mars 1836 d'Armans-Alexis Monteil pour le prix de 200 francs, parmi 52 volumes mss. y compris 3 rouleaux; cf. B.n.F., département des Manuscrits, registre des acquisitions 1833-1848, n° 1875 "16 terriers"

Évangile de saint Jean.

Acquis le 2 avril 1743 de madame du Faÿ parmi 11 mss. pour le prix global de 1200 livres; cf. B.n.F., département des Manuscrits, Archives Ancien Régime 65, registre des acquisitions du département des Manuscrits 1667-1758, f. 291 "n° 87. Codex evangelii secundum Joannem, litteris auro depictis"; mention de la main de l'abbé Sallier "De madame du Fay. 12" (contreplat sup.); — note du XVe s. "Iste liber emptus fuit de precio scutorum LXV (...) M° CCCC° LXV°" (contreplat sup.); — anciennes cotes "87", "17" (Cv)

Exposition de Jean diacre sur la Genèse, etc.

Catalogue de l'abbaye de Corbie (éd. d'E. Coyecque, Cat des mss des bibliothèques de France, XIX, p.XI-XLVIII) XIIIe s.: n°246; 1621: n°420 Ex-libris : f.1 : « Sti Germani a Pratis »