1000 resultados para Master tiedon hallinta


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In the increasingly competitive market of higher education introduced by the Bologna Declaration, understanding the decision-making of master in management students is at the center of institutional management and marketing efforts on its mission to attract prospective students in a less costly, more efficient manner. The means-end chain approach, applied to the choice of a Portuguese institution in which to pursue a master in management, points to the position in rankings and to the non-specificity of the program as the most important attributes. Additionally, results show that students with distinct demographic, household, or background characteristics choose in significantly different manners.

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Due to water scarcity, it is important to organize and regulate water resources utilization to satisfy the conflicting water demands and needs. This paper aims to describe a comprehensive methodology for managing the water sector of a defined urbanized region, using the robust capabilities of a Geographic Information System (GIS). The proposed methodology is based on finding alternatives to cover the gap between recent supplies and future demands. Nablus which is a main governorate located in the north of West Bank, Palestine, was selected as case study because this area is classified as arid to semi-arid area. In fact, GIS integrates hardware, software, and data for capturing, managing, analyzing, and displaying all forms of geographic information. The resulted plan of Nablus represents an example of the proposed methodology implementation and a valid framework for the elaboration of a water master plan.

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Esta Guía nace con la intención de impulsar en esta situación poco favorable el desarrollo del mencionado curso de postgrado en la universidad española. En ese sentido, pretende ser un recurso a utilizar por el profesorado universitario y el grupo de expertos en accesibilidad que constituya el futuro equipo docente de esta iniciativa formativa, como punto de partida para el necesario proceso de concreción curricular que tendrán que realizar. Queremos destacar aquí que esta guía no se concibe, por tanto, como el programa de un Master en accesibilidad Universal, aunque incluye a modo de ejemplo una propuesta concreta, sino como un conjunto de recursos a utilizar para elaborarlo, respetando así el principio de autonomía universitaria y docente en el que creemos firmemente.

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The class II transactivator (CIITA) has been referred to as the "master control factor" for the expression of MHC class II (MHCII) genes. As our knowledge on the specificity and function of CIITA grows, it is becoming increasingly evident that this sobriquet is entirely justified. First, despite extensive investigations, the major target genes of CIITA remain those implicated in the presentation of antigenic peptides by MHCII molecules. Although other putative target genes have been reported, the contribution of CIITA to their expression remains indirect, controversial or comparatively minor relative to its decisive role as a regulator of MHCII and related genes. Second, the most important parameter dictating MHCII expression is by far the expression pattern of the gene encoding CIITA (MHC2TA). The vast majority of signals that activate or repress MHCII expression under physiological and pathological situations converge on one or more of the three alternative promoters that drive transcription of the MHC2TA gene. In short, with respect to its specificity and its exquisitely controlled pattern of expression, CIITA is by a long stretch the single most important transcription factor for the regulation of genes required for MHCII-restricted antigen-presentation.

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Efficient priming of adaptive immunity depends on danger signals provided by innate immune pathways. As an example, inflammasome-mediated activation of caspase-1 and IL-1beta is crucial for the development of reactive T cells targeting sensitizers like dinitrofluorobenzene (DNFB). Surprisingly, DNFB and dinitrothiocyanobenzene provide cross-reactive Ags yet drive opposing, sensitizing vs tolerizing, T cell responses. In this study, we show that, in mice, inflammasome-signaling levels can be modulated to turn dinitrothiocyanobenzene into a sensitizer and DNFB into a tolerizer, and that it correlates with the IL-6 and IL-12 secretion levels, affecting Th1, Th17, and regulatory T cell development. Hence, our data provide the first evidence that the inflammasome can define the type of adaptive immune response elicited by an Ag, and hint at new strategies to modulate T cell responses in vivo.

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The H∞ synchronization problem of the master and slave structure of a second-order neutral master-slave systems with time-varying delays is presented in this paper. Delay-dependent sufficient conditions for the design of a delayed output-feedback control are given by Lyapunov-Krasovskii method in terms of a linear matrix inequality (LMI). A controller, which guarantees H∞ synchronization of the master and slave structure using some free weighting matrices, is then developed. A numerical example has been given to show the effectiveness of the method

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L'objectiu d'aquest projecte és la creació d'una prova de concepte de comunicacions unificades utilitzant productes de programari lliure existents. Aquesta prova de concepte servirà per poder fer demostracions del funcionament general del programari implicat amb el mínim de preparacions, instal·lacions i configuracions prèvies possibles. El projecte es dividirà en dos appliances o LiveCD, creats a traves de Suse Studio, anomenats Comunicacions Unificades i Comunicacions Unificades 2.Els productes de programari lliure que composen el Servidor de Comunicacions Unificades els podem classificar en productes principals, plugins o addons dels productes i productes secundaris.Com a productes principals tenim els següents servidors que cobreixen les necessitats principals del Servidor de Comunicacions Unificades:Asterisk v1.8.3 : Servidor de telefonia amb veu sobre IP (VoIP).FreePBX v2.9.0beta2 : GUI de control i administració d'Asterisk.Openfire v3.7.0 : Servidor de IM basat en el protocol XMPP.BigBlueButton v0.71a : Sistema de conferència web. Pendent finalitzar-ne l'implementació.I els seguents productes principals que cobreixen les necessitats del servidor de Comunicacions Unificades 2:Zimbra v7.0.1 : Servidor de correu electrònic i de calendari. Pendent resoldre conflicte inicialització LDAP.Funambol v9.0.0 : Sincronització Zimbra amb mòbils.Com a plugins o addons del productes tenim, classificats segons el producte:Asterisk addons: chan_jingle i chan_gtalkZimlets: Asterisk, Google Translator, Funambol i SocialsOpenfire pugins: Asterisk, Facebook i GmailCom a productes secundaris tenim els clients necessaris per poder utilitzar l'appliance:Firefox: Navegador web que servirà com a interfície d'usuari per les diferents eines d'administració i la demostració.Pigdin o Spark: Clients de missatgeria instantània, per l'appliance Comunicacions Unificades.A més d'instal·lar aquests productes, s'implementa una interfície web, mitjançant Drupal, en format HTML per enllaçar les diferents eines d'administració dels productes, per a cadascun dels dos appliances i es realitzara un Kiosk appliance per a familiaritzar-se amb l'entorn SuseStudio.

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Specialised plant cell types often locally modify their cell walls as part of a developmental program, as do cells that are challenged by particular environmental conditions. Modifications can include deposition of secondary cellulose, callose, cutin, suberin or lignin. Although the biosyntheses of cell wall components are more and more understood, little is known about the mechanisms that control localised deposition of wall materials. During metaxylem vessel differentiation, site-specific cell wall deposition is locally prevented by the microtubule depolymerising protein MIDD1, which disassembles the cytoskeleton and precludes the cellulose synthase complex from depositing cellulose. As a result, metaxylem vessel secondary cell wall appears pitted. How MIDD1 is tethered at the plasma membrane and how other cell wall polymers are locally deposited remain elusive. Casparian strips in the root endodermis represent a further example of local cell wall deposition. The recent discovery of the Casparian Strip membrane domain Proteins (CASPs), which are located at the plasma membrane and are important for the site-specific deposition of lignin during Casparian strip development, establishes the root endodermis as an attractive model system to study the mechanisms of localised cell wall modifications. How secondary modifications are modulated and monitored during development or in response to environmental changes is another question that still misses a complete picture.

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The transformer (tra) gene is a key regulator in the signalling hierarchy controlling all aspects of somatic sexual differentiation in Drosophila and other insects. Here, we show that six of the seven sequenced ants have two copies of tra. Surprisingly, the two paralogues are always more similar within species than among species. Comparative sequence analyses indicate that this pattern is owing to the ongoing concerted evolution after an ancestral duplication rather than independent duplications in each of the six species. In particular, there was strong support for inter-locus recombination between the paralogues of the ant Atta cephalotes. In the five species where the location of paralogues is known, they are adjacent to each other in four cases and separated by only few genes in the fifth case. Because there have been extensive genomic rearrangements in these lineages, this suggests selection acting to conserve their synteny. In three species, we also find a signature of positive selection in one of the paralogues. In three bee species where information is available, the tra gene is also duplicated, the copies are adjacent and in at least one species there was recombination between paralogues. These results suggest that concerted evolution plays an adaptive role in the evolution of this gene family.

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Tutkimus liittyi osana Helsingin yliopistollisen sairaalan yhden toimialan kehittämishankkeeseen. Tavoitteena on, että sairaanhoitajien osaaminen vastaa toimintaa. NCS- mittari (Nurse Competence Scale, Meretoja 2003) on kehitetty sairaanhoitajan ammattipätevyyden arviointiin ammattiuramallin mukaisesti. Osaamiskartoitukseen soveltuva 73 väittämää sisältävä NCS- mittari koostuu seitsemästä ammattipätevyyttä kuvaavasta summamuuttujasta ja sillä voidaan arvioida hoitajien ammattipätevyyden tasoa erilaisissa toimintayksiköissä. Tutkimuksen tarkoituksena oli tuottaa menetelmä yksikkökohtaisen sairaanhoitajan osaamisen tavoitetason määrittelemiseksi sekä laatia yksikkökohtaiset sairaanhoitajan tehtävän osaamisalueiden taso- odotukset NCS väittämien ja niiden tärkeyden avulla. Menetelmänä käytettiin delfitekniikkaa, jossa on ominaista asiantuntijaryhmän käyttö ja tutkimuksen toistaminen. Asiantuntijaryhmä (n=8) oli erityisasiantuntemusta omaava, monipuolinen ja tulevaisuusorientoitunut. Asiantuntija- arviointi toteutettiin kolmessa vaiheessa. Ensimmäisessä vaiheessa asiantuntijat vastasivat nimeämällä viisi keskeisintä erikoisalan toimintaan vaikuttavaa muutostekijää tulevan viiden vuoden aikana ja kuvasivat mitä haasteita edellä mainitut muutokset aiheuttivat sairaanhoitajien osaamiseen leikkaus- ja anestesiaosastolla. Toisessa vaiheessa asiantuntijat arvioivat yksikön potilaiden hoidon kannalta sairaanhoitajan tavoitellun osaamistason ja tärkeyden NCS- mittarin (VAS= Visual Analogue Scale- jana 0- 100 ja tärkeys 0-3) avulla. Kolmannessa vaiheessa asiantuntijapaneelissa määriteltiin edellisissä vaiheissa saadun tiedon pohjalta osaamisen tavoitetaso ja tärkeys leikkaus- ja anestesiaosastolla. Tulokset analysoitiin sisällön analyysilla ja tilastollisin menetelmin. Sairaanhoitajalta odotetaan monipuolisia tietoja ja taitoja kokonaisvaltaisesta potilaan hoitotyöstä, perehtymistä iäkkään ja monisairaan potilaan hoitamiseen. Myös tietotekniset taidot korostuvat entisestään sairaanhoitajan työssä leikkaus- ja anestesiaosastolla. Sairaanhoitajalta vaaditaan hyvää kielitaitoa, positiivista asennetta ja sopeutumista muuttuvaan hoitoympäristöön. Leikkaus- ja anestesiaosastolla tavoitetasoiltaan korkeimmiksi sekä tärkeimmiksi osa- alueiksi nousivat auttaminen, tilannehallinta, hoitotoimien hallinta ja työrooli. Tuloksia hyödynnetään hoitohenkilöstön osaamisen hallinnassa ja johtamisessa sekä täydennyskoulutuksen suunnittelussa.