212 resultados para Kastner
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"Table alphabétique des principaux termes employés dans les proverbes musicaux, de leurs congénères, de leurs fréquentatifs et de leurs dérivés pris au propre ou au figure": p. [665]-677.
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Inaug. - diss. - München.
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Mode of access: Internet.
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Mode of access: Internet.
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Inaug.-diss.--Munich.
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Edited by E.F. Kastner.
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Mode of access: Internet.
Einleitung in die neuere Chemie : Behufs seiner Vorlesungen und zum Selbstunterrichte für Anfänger /
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Includes bibliographical references.
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Includes bibliographical references and indexes.
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Mode of access: Internet.
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Mode of access: Internet.
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Thesis (doctoral)--Universitat Bern.
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Thesis (doctoral)--Georg-Augusts-Universitat zu Gottingen, 1895.
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Thesis (doctoral)--K. Bayer. Ludwig-Maximilians-Universitat Munchen, 1907.
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A range of particulate delivery systems have been considered as vaccine adjuvants. Of these systems, liposomes offer a range of advantages including versatility and flexibility in design format and their ability to incorporate a range of immunomodulators and antigens. Here we briefly outline research, from within our laboratories, which focused on the systematic evaluation of cationic liposomes as vaccines adjuvants. Our aim was to identify physicochemical characteristics that correlate with vaccine efficacy, with particular consideration of the interlink between depot-forming action and immune responses. A variety of parameters were investigated and over a range of studies we have confirmed that cationic liposomes, based on dimethyldioctadecylammonium bromide and trehalose 6,6'-dibehenate formed a depot at the injection site, which stimulates recruitment of antigen presenting cells to the injection site and promotes strong humoral and cell-mediated immune responses. Physicochemical factors which promote a strong vaccine depot include the combination of a high cationic charge and electrostatic binding of the antigen to the liposome system and the use of lipids with high transition temperatures, which form rigid bilayer vesicles. Reduction in vesicle size of cationic vesicles did not promote enhanced drainage from the injection site. However, reducing the cationic nature through substitution of the cationic lipid for a neutral lipid, or by masking of the charge using PEGylation, resulted in a reduced depot formation and reduced Th1-type immune responses, while Th2-type responses were less influenced. These studies confirm that the physicochemical characteristics of particulate-based adjuvants play a key role in the modulation of immune responses.