989 resultados para Karl Joel


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Karl Kraus a repris, mais en l’amplifiant, la métaphore de Balzac qui compare la presse à une prostituée. Mais il élargit considérablement son propos dans une dénonciation de l’attitude hypocrite de la bourgeoisie et de la presse bourgeoise par rapport à la prostitution physique. Il développe pour ce faire une poétique où une pratique généralisée de l’antanaclase permet de dénoncer à la fois la presse et ses lieux communs par rapport aux prostituées.

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beleuchtet von [Emanuel] S[chwarzschild]

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hrsg. von F. Luthmer. Photogr. aufgen. von Wehe-Wehl

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von Adolf Lewin

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The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.

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von Julius Plotke

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Tübingen, Univ., Universitätsprogramm, 1881

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Hermann Becker