Median rituaalit ja moderni pyhyys : kuoliko Michael Jackson pyhän uhrikuoleman?

Kirjallisuusarvostelu

Choræus, Michael

f. 15.3.1774 i Vörå d. 3.6.1806 i Stockholm, Sverige Michael Choræus har gått till historien som sen upplysningstida finländsk diktare. Han publicerade sina litterära verk kring år 1800, vid sidan om sin akademiska och teologiska bana. I fråga om stil och tematik var han influerad av den samtida och likaså svenskspråkiga diktarkollegan Frans Michael Franzén. I sin samtid väckte Choræus uppseende med sin kvickhet och sitt intellekt, samt har setts som den mest begåvade finländska lyrikern i sin tid. I hans produktion ingår flytande verskonst som inte sällan tonsatts, däribland också psalmbearbetningar, samt även t.ex. tillfällesdikt och satir. Som exempel på hans dikter kan nämnas En tanke på min egen graf, Ehrensvärd. Skaldesång och Lilla Calle (utgivna i t.ex. tidningar under diktarens livstid och senare i Choræus samlade skaldestycken 1815). Biografiskt lexikon för Finland: http://www.blf.fi/artikel.php?id=2355

The renal and hepatic distribution of Bence Jones proteins depends on glycosylation: a scintigraphic study in rats

The aim of the present study was to evaluate renal and liver distribution of two monoclonal immunoglobulin light chains. The chains were purified individually from the urine of patients with multiple myeloma and characterized as lambda light chains with a molecular mass of 28 kDa. They were named BJg (high amount of galactose residues exposed) and BJs (sialic acid residues exposed) on the basis of carbohydrate content. A scintigraphic study was performed on male Wistar rats weighing 250 g for 60 min after iv administration of 1 mg of each protein (7.4 MBq), as the intact proteins and also after carbohydrate oxidation. Images were obtained with a Siemens gamma camera with a high-resolution collimator and processed with a MicroDelta system. Hepatic and renal distribution were established and are reported as percent of injected dose. Liver uptake of BJg was significantly higher than liver uptake of BJs (94.3 vs 81.4%) (P<0.05). This contributed to its greater removal from the intravascular compartment, and consequently lower kidney accumulation of BJg in comparison to BJs (5.7 vs 18.6%) (P<0.05). After carbohydrate oxidation, there was a decrease in hepatic accumulation of both proteins and consequently a higher renal overload. The tissue distribution of periodate-treated BJg was similar to that of native BJs: 82.7 vs 81.4% in the liver and 17.3 vs 18.6% in the kidneys. These observations indicate the important role of sugar residues of Bence Jones proteins for their recognition by specific membrane receptors, which leads to differential tissue accumulation and possible toxicity

Nephrotoxicity of Bence-Jones proteins: interference in renal epithelial cell acidification

The aim of the present study was to evaluate the acidification of the endosome-lysosome system of renal epithelial cells after endocytosis of two human immunoglobulin lambda light chains (Bence-Jones proteins, BJP) obtained from patients with multiple myeloma. Renal epithelial cell handling of two BJP (neutral and acidic BJP) was evaluated by rhodamine fluorescence. Renal cells (MDCK) were maintained in culture and, when confluent, were incubated with rhodamine-labeled BJP for different periods of time. Photos were obtained with a fluorescence microscope (Axiolab-Zeiss). Labeling density was determined on slides with a densitometer (Shimadzu Dual-Wavelength Flying-Spot Scanner CS9000). Endocytosis of neutral and acidic BJP was correlated with acidic intracellular compartment distribution using acridine orange labeling. We compared the pattern of distribution after incubation of native neutral and acidic BJP and after complete deglycosylation of BJP by periodate oxidation. The subsequent alteration of pI converted neutral BJP to acidic BJP. There was a significant accumulation of neutral BJP in endocytic structures, reduced lysosomal acidification, and a diffuse pattern of acidification. This pattern was reversed after total deglycosylation and subsequent alteration of the pI to an acidic BJP. We conclude that the physicochemical characteristics of BJP interfere with intracellular acidification, possibly explaining the strong nephrotoxicity of neutral BJP. Lysosomal acidification is fundamental for adequate protein processing and catabolism.

De principis primogeniti jure & officio aphorismos politicos consentiente ampliss. facult. phil. Aboens. praeside viro cl. mag. Algotho A. Scarin, histor. & philos. civil. profess. reg. & ord. Ad diem XII. Aprilis anno 1738, dissertatione graduali publicae disquisitioni submittit Michael Lebell Ostrobotniensis

Invokaatio: Q.B.V.

Antiphonarium (MS C.ö.III.20, "Michael Ericin antifonarium")

A copy of a Dominican antiphonary produced for Lutheran use in the second half of the sixteenth century. The sanctoral reflects Lutheran tastes, with St Henry, the patron of Finland, being the only non-biblical saint.

La separación de los caminos (un análisis crítico del libro homónimo de Michael Friedman)

La filosofía contemporánea se hacaracterizadopor la presencia de un dualismo esquizoide entre la tradición analítica e la tradición fenomenológico hermenéutica. El origen histórico del mismo puede ser fijado en el Congreso de Davos, el cual, por otra parte, señala el comienzo del olvido de un otro programa, la filosofía de las formas simbólicas de E. Cassirer e que hoy puede ser considerado como alternativa e posible dirección de superación del dualismo mencionado. Tal es, en síntesis, la posición defendida por M. Friedman en su reciente monografía, escrita en el contexto de la convicción de una crisis derivada del agotamiento de las tradiciones y de la subsecuente necesidad de una reorientación. El texto que ofrecemos comenta críticamente el estudio de Friedman, mostrando donde y cómo él puede y debe ser completado o, eventualmente, corregido.

Das Grosfürstenthum Finland Augsburg, zu finden bey Johann Michael Probst, 1788

Janamittakaavat: Geographil Meile, Schwedische und Dännische, Norwegische, Franzöfische Meile.

[Charles Michael] Schwab (roi de l'acier) [américain en tenue de golf] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58887