Climate signatures in corals of the tropical-temperate transition zone (Late Miocene, Crete/Greece)

The present study describes a Late Miocene (early Tortonian - early Messinian) transitional carbonate system that combines elements of tropical and cool-water carbonate systems (Irakleion Basin, island of Crete, Greece). As documented by stratal geometries, the submarine topography of the basin was controlled by tilting blocks. Coral reefs formed by Porites and Tarbellastrea occurred in a narrow clastic coastal belt along a „central Cretan landmass“, and steep escarpments formed by faulting. Extensive covers of level-bottom communities existed in a low-energy environment on the gentle dip-slope ramps of the blocks that show the widest geographical distribution within the basin. Consistent patterns of landward and basinward shift of coastal onlap in all outcrop studies reveal an overriding control of 3rd and 4th order sea level changes on sediment dynamics and facies distributions over block movements. An increasingly dry climate and the complex submarine topography of the fault block mosaic kept sediment and nutrient discharge at a minimum. The skeletal limestone facies therefore reflects oligotrophic conditions and a sea surface temperature (SST) near the lower threshold temperature of coral reefs in a climatic position transitional between the tropical coral reef belt and the temperate zone. Stable isotope records (δ18O, δ13C) from massiv, exceptionally preserved Late Miocene aragonite coral skeletons reflect seasonal changes in sea surface temperature and symbiont autotrophy. Spectral analysis of a 69 years coral δ18O record reveals significant variance at interannual time scales (5-6 years) that matches the present-day eastern Mediterranean climate variability controlled by the Arctic Oscillation/North Atlantic Oscillation (AO/NAO), the Northern Hemisphere’s dominant mode of atmospheric variability. Supported by simulations with a complex atmospheric general circulation model coupled to a mixed-layer ocean model, it is suggested, that climate dynamics in the eastern Mediterranean and central Europe reflect atmospheric variability related to the Icelandic Low 10 million years ago. Usually, Miocene corals are transformed in calcite spar in geological time and isotope values are reset by diagenetic alteration. It is demonstrated that the relicts of growth bands represent an intriguing source of information for the growth conditions of fossil corals. Recrystallized growth bands were measured systematically in massive Porites from Crete. The Late Miocene corals were growing slowly with 2-4 mm/yr, compatible with present-day Porites from high latitude reefs, a relationship that fits the position of Crete at the margin of the Miocene tropical reef belt. Over Late Miocene time (Tortonian - early Messinian) growth rates remained remarkably constant, and if the modern growth temperature relationship for massive Porites applies to the Neogene, minimum (winter) SST did not exceed 19-21°C.

Traduzione del primo canto dell'inferno dantesco in arabo

In this thesis, I have chosen to translate from Italian into Arabic Canto I of the Inferno, from Dante Alighieri’s epic poem the Divine Comedy (La Divina Commedia) because it’s a masterpiece in both Italian and world literature. Also I have selected it for its artistic value and the universal themes that it depicts. In fact, my purpose in translating this great work into Arabic is to extol the cultural and universal aspects that can be common to human beings everywhere. My paper is written in Arabic and has six sections: A brief introduction on Dante’s life, an introduction to the Divine Comedy, a summary of Canto 1 of the Inferno and its analysis, Canto I of the Inferno in Italian, its translation into Arabic and finally a comment on the translation. The first part -a summary of Dante’s life was presented. The second part of my paper is an introduction to the Divine Comedy, the allegorical epic poem, consisting of three parts: The Inferno (Hell), Purgatorio (Purgatory), and Paradiso (Paradise). The third part is a summary and analysis of Canto 1 of the Inferno, Dante’s most renowned verses. The analysis of Canto highlights the everlasting conflict of man– sinning and giving in to temptation but then trying to repent and search for his soul’s salvation. He reflects on sin, existence, truth, God, love and salvation in his struggle through the dark and gloomy forest which symbolizes conflict and temptations man may succumb to. The influence of Christianity and the Middle ages here shows his commitment to religion and faith. Moreover, his meeting of Virgil, who guides him to the mountain during his journey to salvation, reflects the positive impact of Virgil’s philosophy on Dante. The fourth part presents the Italian version of Canto 1 of the Inferno. The fifth section of my paper is the translation of Canto 1 of the Inferno from Italian to Arabic. Translating an excerpt of Dante’s masterpiece was not an easy task: I had to consult several critique texts besides the Italian source text with explanations, and also some English versions to overcome any translation difficulties. As a student of translation, my goal was to be faithful in relaying to the Arabic audience the authenticity of Dante’s work, his themes, passions and aesthetic style. Finally, I present a conclusion including a comment on the translation and the bibliography of the sources I have consulted.

Soluble tumour necrosis factor receptors sTNFR1 and sTNFR2 are produced at sites of inflammation and are markers of arthritis activity in Behçet's disease

OBJECTIVE: We analysed the production of soluble tumour necrosis factor receptors sTNFR1 and sTNFR2 at sites of inflammation and measured their plasma concentrations to evaluate them as biological markers of disease activity. METHODS: Plasma samples of 35 patients with Behçet's disease (BD) were collected prospectively at monthly intervals and grouped for inactive disease, active BD without arthritis, and active BD with arthritis. sTNFR1 and sTNFR2 concentrations were measured using immunoassays and compared with other biological disease activity parameters. Plasma sTNFR levels were compared to synovial fluid (SF) levels in seven patients. Sixteen tissue samples of mucocutaneous lesions were stained for TNFR2 expression by immunohistochemistry. RESULTS: sTNFR1 and sTNFR2 were found at increased plasma concentrations in active BD, with the highest concentration in active BD with arthritis (p<0.001). Concentrations of both sTNFRs were at least three times higher in SF of arthritic joints than in the corresponding plasma samples (p = 0.025). A change of more than 1 ng/mL of sTNFR2 plasma concentrations correlated with a concordant change in arthritic activity (96% confidence interval). Sensitivity to change was superior to that of sTNFR1, and other biological disease activity parameters such as erythrocyte sedimentation rate (ESR), immunoglobulin (Ig)G, IgA, and interleukin (IL)-10 plasma concentrations. A strong staining for TNFR2 was found in mucocutaneous lesions, where mast cells were identified as the major source for this receptor. CONCLUSIONS: This longitudinal study demonstrates that sTNFR2 plasma concentrations are closely linked with active BD, and especially with arthritis. Taken together with the expression of TNFR molecules in mast cells of mucocutaneous lesions, our results indicate a fundamental role for the TNF/TNFR pathway in BD.

Geology and Ore Deposits of the Clinton Mining District

This report includes the results of geological investigation of the Clinton Mining District and the Hidden Treasure Mine.The Clinton Mining District is an unorganized mining dis­trict situated in the Garnet Range two and one-half miles northeast of the town of Clinton, Montana, which is on the Northern Pacific Railway and the Chicago, Milwaukee, St. Paul, and Pacific Railroad seventeen miles east of the city of Missoula. The district is in the same range of mountains as the Gar­net Mining District and the drainage from the district covered is to the south into the Hell Gate or Clarks Fork of the Colum­bia River. The main stream is known as Trail creek, which runs in a southerly direction from the area studied.

A deviant EEG brain microstate in acute, neuroleptic-naive schizophrenics at rest

Momentary brain electric field configurations are manifestations of momentary global functional states of the brain. Field configurations tend to persist over some time in the sub-second range (“microstates”) and concentrate within few classes of configurations. Accordingly, brain field data can be reduced efficiently into sequences of re-occurring classes of brain microstates, not overlapping in time. Different configurations must have been caused by different active neural ensembles, and thus different microstates assumedly implement different functions. The question arises whether the aberrant schizophrenic mentation is associated with specific changes in the repertory of microstates. Continuous sequences of brain electric field maps (multichannel EEG resting data) from 9 neuroleptic-naive, first-episode, acute schizophrenics and from 18 matched controls were analyzed. The map series were assigned to four individual microstate classes; these were tested for differences between groups. One microstate class displayed significantly different field configurations and shorter durations in patients than controls; degree of shortening correlated with severity of paranoid symptomatology. The three other microstate classes showed no group differences related to psychopathology. Schizophrenic thinking apparently is not a continuous bias in brain functions, but consists of intermittent occurrences of inappropriate brain microstates that open access to inadequate processing strategies and context information

EEG microstate duration and syntax in acute, medication-naive, first-episode schizophrenia: a multi-center study

In young, first-episode, productive, medication-naive patients with schizophrenia, EEG microstates (building blocks of mentation) tend to be shortened. Koenig et al. [Koenig, T., Lehmann, D., Merlo, M., Kochi, K., Hell, D., Koukkou, M., 1999. A deviant EEG brain microstate in acute, neuroleptic-naïve schizophrenics at rest. European Archives of Psychiatry and Clinical Neuroscience 249, 205–211] suggested that shortening concerned specific microstate classes. Sequence rules (microstate concatenations, syntax) conceivably might also be affected. In 27 patients of the above type and 27 controls, from three centers, multichannel resting EEG was analyzed into microstates using k-means clustering of momentary potential topographies into four microstate classes (A–D). In patients, microstates were shortened in classes B and D (from 80 to 70 ms and from 94 to 82 ms, respectively), occurred more frequently in classes A and C, and covered more time in A and less in B. Topography differed only in class B where LORETA tomography predominantly showed stronger left and anterior activity in patients. Microstate concatenation (syntax) generally were disturbed in patients; specifically, the class sequence A→C→D→A predominated in controls, but was reversed in patients (A→D→C→A). In schizophrenia, information processing in certain classes of mental operations might deviate because of precocious termination. The intermittent occurrence might account for Bleuler's “double bookkeeping.” The disturbed microstate syntax opens a novel physiological comparison of mental operations between patients and controls.

Low resolution brain electromagnetic tomography (LORETA) functional imaging in acute, neuroleptic-naive, first-episode, productive schizophrenia

Functional imaging of brain electrical activity was performed in nine acute, neuroleptic-naive, first-episode, productive patients with schizophrenia and 36 control subjects. Low-resolution electromagnetic tomography (LORETA, three-dimensional images of cortical current density) was computed from 19-channel of electroencephalographic (EEG) activity obtained under resting conditions, separately for the different EEG frequencies. Three patterns of activity were evident in the patients: (1) an anterior, near-bilateral excess of delta frequency activity; (2) an anterior-inferior deficit of theta frequency activity coupled with an anterior-inferior left-sided deficit of alpha-1 and alpha-2 frequency activity; and (3) a posterior-superior right-sided excess of beta-1, beta-2 and beta-3 frequency activity. Patients showed deviations from normal brain activity as evidenced by LORETA along an anterior-left-to-posterior-right spatial axis. The high temporal resolution of EEG makes it possible to specify the deviations not only as excess or deficit, but also as inhibitory, normal and excitatory. The patients showed a dis-coordinated brain functional state consisting of inhibited prefrontal/frontal areas and simultaneously overexcited right parietal areas, while left anterior, left temporal and left central areas lacked normal routine activity. Since all information processing is brain-state dependent, this dis-coordinated state must result in inadequate treatment of (externally or internally generated) information.

History of Medicine Schedule and Abstracts 2009-2010

From Genes to Genome: An historical perspective (David Wheeler) Ignaz Semmelweis: Medical Prophet Without Honor (Ronald L. Young) Why Lewis Thomas, MD is Not a Bore: The Life of a Biology Watcher (Steven Greenberg) Doctors from Hell: The Horrific Account of Nazi Experiments on Humans (Vivien Spitz) Illuminating Autism: Passing the Torch from the Twentieth Century (Student Essay Contest Winners) (Lynn Yudofsky) Healing Beyond Hippocrates: The Temples of Asclepius and Public Health Care in Ancient Greece (Andrew Baldwin) Iron Wills and Iron Lungs: The Polio Years in Texas (Heather Green Wooten) William Osler and the Inspirational Uses of History (Michael Bliss) Working Too Hard and Achieving Too Much: The Cost of Being Harvey Cushing (Michael Bliss) Medicine in Ancient Egypt (Gene Boisaubin) The History of Diabetes (Jeff Unger)

Observations d'un Alsacien sur l'affaire présenté des juifs d'Alsace

[Verf.[[Elektronische Ressource]] : François Joseph Antoine de Hell]

Der erste Januar 1850: (Ein Traum): Ein dichtes Netz von tanzenden Schneeflocken hat der winterliche Himmel über die alte ehrwürdige Stadt Frankfurt ausgespannt ...

Welsch (Projektbearbeiter): Zukunftsvision: die in der Frankfurter Paulskirche zusammengetretene Nationalversammlung der deutschen Republik verurteilt Friedrich Wilhelm IV. am 1. Januar 1850 wegen Hochverrats zum Tode. Hintergrund: der von Preußen am 26. August 1848 unter dem Druck Englands und Rußlands mit Dänemark abgeschlossene Waffenstillstand von Malmö, der in Deutschland ganz allgemein als Preisgabe nationaler Interessen interpretiert wird

Gruss aus Bayreuth! : Es leuchtet Dein Ruhm wie Sonnenstrahl,

hell durch die Lande, Held Parsifal!

"En el monumento Resuçitest, fust alos ynfiernos" : ¿Error del poeta o influencia de una fuente en el Cantar de Mio Cid?

El presente trabajo vuelve a los vv. 358-361 del Cantar de Mio Cid sobre un tema que ha perturbado a la crítica: el texto conservado en el Códice de Vivar refiere que Jesús resucitó primero, y luego descendió a los Infiernos, lo cual implica una inversión del orden tradicional de los acontecimientos. En consecuencia, se revisan aquí las distintas opiniones sobre el particular, que en general pueden dividirse básicamente en dos grupos -aquellas que sostienen que el poeta cometió un error, y otras que afirman que el autor del poema adhirió a un determinado modelo, proveniente ya de la épica francesa, ya de la liturgia-, y se intenta arribar a una solución que considere más satisfactoriamente la especificidad del texto manuscrito.

"En el monumento Resuçitest, fust alos ynfiernos" : ¿Error del poeta o influencia de una fuente en el Cantar de Mio Cid?

El presente trabajo vuelve a los vv. 358-361 del Cantar de Mio Cid sobre un tema que ha perturbado a la crítica: el texto conservado en el Códice de Vivar refiere que Jesús resucitó primero, y luego descendió a los Infiernos, lo cual implica una inversión del orden tradicional de los acontecimientos. En consecuencia, se revisan aquí las distintas opiniones sobre el particular, que en general pueden dividirse básicamente en dos grupos -aquellas que sostienen que el poeta cometió un error, y otras que afirman que el autor del poema adhirió a un determinado modelo, proveniente ya de la épica francesa, ya de la liturgia-, y se intenta arribar a una solución que considere más satisfactoriamente la especificidad del texto manuscrito.

"En el monumento Resuçitest, fust alos ynfiernos" : ¿Error del poeta o influencia de una fuente en el Cantar de Mio Cid?

El presente trabajo vuelve a los vv. 358-361 del Cantar de Mio Cid sobre un tema que ha perturbado a la crítica: el texto conservado en el Códice de Vivar refiere que Jesús resucitó primero, y luego descendió a los Infiernos, lo cual implica una inversión del orden tradicional de los acontecimientos. En consecuencia, se revisan aquí las distintas opiniones sobre el particular, que en general pueden dividirse básicamente en dos grupos -aquellas que sostienen que el poeta cometió un error, y otras que afirman que el autor del poema adhirió a un determinado modelo, proveniente ya de la épica francesa, ya de la liturgia-, y se intenta arribar a una solución que considere más satisfactoriamente la especificidad del texto manuscrito.

Platinum-group element abundances in background samples and the K-T boundary interval from DSDP Hole 91-596 (Table 2)

New data on Ru/Ir abundance ratios are presented for nonmarine (Hell Creek, Montana; Frenchman River, Saskatchewan) and marine Cretaceous-Tertiary boundary sites (Brazos River, Texas; Beloc, Haiti; DSDP 577 and DSDP 596). The Ru/Ir ratio varies from 0.5 to 1 within 4000 km of Chicxulub and increases to 2-3 at paleodistances (65 Ma) of up to 12,000 km from the impact site. For CI chondrites, Ru/Ir = 1.5. A ballistic model of ejecta cloud cooling and expansion, which employs the available vapor-pressure versus temperature data for Ru and It, predicts qualitatively similar global variation in the Ru/Ir ratio but by only a factor of 1.5. We infer that several other factors, such as remobilization of PGE during diagenesis, preferential oxidation of Ru, condensation kinetics and atmospheric chemical and circulation processes, may account for the observed larger Ru/Ir variation.