Reauthorization of the Substance Abuse and Mental Health Services Administration : hearing before the Subcommittee on Substance Abuse and Mental Health Services of the Committee on Health, Education, Labor, and Pensions, United States Senate, One Hundred Eighth Congress, first session, on examining proposed legislation authorizing funds for the Substance Abuse and Mental Health Services Administration, focusing on the importance of substance abuse prevention, July 15, 2003.

Shipping list no.: 2004-0105-P.

Discussion of focusing requirements for the Stanford two-mile accelerator /

AEC Contract AT(04-3)-400.

Misalignment and quadrupole error effects in a focusing system for the two-mile accelerator /

"AEC Contract AT(04-3)-400."

Optical properties of quadrupole multiplets for sector focusing in the two-mile accelerator /

"AEC Contract AT(04-3)-400."

Misalignment and quadrupole error problems affecting the choice of multiplet type for sector focusing of the two-mile accelerator /

"AEC Contract AT(04-3)-400."

Effects of stray magnetic fields and RF coupler asymmetry in the two-mile accelerator with sector focusing /

"AEC Contract AT(04-3)-400."

Flow focusing in microchannels

A volume-of-fluid numerical method is used to predict the dynamics of drop formation in an axi-symmetric microfluidic flow-focusing geometry for a liquid-liquid system. The Reynolds numbers and Weber numbers approximate those of a three-dimensional flow in recently published experiments. We compare the predicted drop formation with the experimental results at various flow rates, and discuss the mechanisms of drop formation in this context. Despite the differences in geometry, we find qualitative correspondence between the numerical and experimental results. Both end-pinching and capillary-wave instability are important for droplet break-up at the higher flow rates.

Focusing in on structural genomics: The University of Queensland structural biology pipeline

The flood of new genomic sequence information together with technological innovations in protein structure determination have led to worldwide structural genomics (SG) initiatives. The goals of SG initiatives are to accelerate the process of protein structure determination, to fill in protein fold space and to provide information about the function of uncharacterized proteins. In the long-term, these outcomes are likely to impact on medical biotechnology and drug discovery, leading to a better understanding of disease as well as the development of new therapeutics. Here we describe the high throughput pipeline established at the University of Queensland in Australia. In this focused pipeline, the targets for structure determination are proteins that are expressed in mouse macrophage cells and that are inferred to have a role in innate immunity. The aim is to characterize the molecular structure and the biochemical and cellular function of these targets by using a parallel processing pipeline. The pipeline is designed to work with tens to hundreds of target gene products and comprises target selection, cloning, expression, purification, crystallization and structure determination. The structures from this pipeline will provide insights into the function of previously uncharacterized macrophage proteins and could lead to the validation of new drug targets for chronic obstructive pulmonary disease and arthritis. (c) 2006 Elsevier B.V. All rights reserved.

Laser beam self-focusing in the atmosphere

We propose to exploit a self-focusing effect in the atmosphere to assist delivering powerful laser beams from orbit to the ground. We demonstrate through numerical modeling that when the self-focusing length is comparable with the atmosphere height the spot size on the ground can be reduced well below the diffraction limits without beam quality degradation. The density variation suppresses beam filamentation and provides the self-focusing of the beam as a whole. The use of light self-focusing in the atmosphere can greatly relax the requirements for the orbital optics and ground receivers.

The effect of self-focusing on laser space-debris cleaning

A ground-based laser system for space-debris cleaning will use powerful laser pulses that can self-focus while propagating through the atmosphere. We demonstrate that for the relevant laser parameters, this self-focusing can noticeably decrease the laser intensity on the target. We show that the detrimental effect can be, to a great extent, compensated for by applying the optimal initial beam defocusing. The effect of laser elevation on the system performance is discussed.

Borrowing services from nature. Methodologies to evaluate ecosystem services focusing on Hungarian case studies.

In modern societies, humans are largely managing the world's natu­ral resources as if they were limitless. ln fact, even the so-called renewable resources require time tor renewal once they have been used. This kind of human attitude puts pressure on Earth's ecosystems at an unprecedented scale. In order to reverse the recent trend, policies shall tackle the roots of the problems and the drivers behind them must be addressed in order to reduce the pressure on ecosystems, including the overuse of natural resources and ecological space. This publication aims to show good examples tor evaluating natural values and tor showing possible environmental and social impacts of various policies. Considering carefully the examples presented in this publication could play fundamental role in proper decision making that considers environmental and overall sustainability aspects.

The effect of focusing on loan decisions

In this paper we investigate some implications of recent results about salience on loan decisions. Using the framework of focus-weighted utility we show that consumers might take out loans even when that yield them negative utility. We claim however, that consumers are more prudent in their decisions and might be less likely to take out such loans when the usual fixed- and increasing-installment plans are coupled with a decreasing-installment option. We argue that harmful loan consumption, especially in the case of loans with increasing-installments (e.g. alternative mortgage loans), could be decreased if a policy would prescribe presentation of loan repayment schedules in a way that employs this effect. Moreover, using the model of focus-weighted utility we give a possible explanation for the unpopularity of decreasing-installment plans, the success of increasing-installment plans and their higher default rate during the financial crisis.