Pilomyxoid astrocytoma of the brainstem

A pilomyxoid astrocytoma is a recently described tumor that occurs predominantly in the hypothalamic-chiasmatic region and is rarely found elsewhere. It has similar features as pilocytic astrocytomas, but has distinct histological characteristics and a poorer prognosis. A pilomyxoid astrocytoma is an aggressive tumor, and increased awareness is necessary with a suspect case. We present the first case of a pilomyxoid astrocytoma of the brainstem described after the newest World Health Organization classification of central nervous system tumors. © F.O. Pereira et al., 2013. Licensee PAGEPress, Italy.

Motor Recovery and Synaptic Preservation after Ventral Root Avulsion and Repair with a Fibrin Sealant Derived from Snake Venom

Background:Ventral root avulsion is an experimental model of proximal axonal injury at the central/peripheral nervous system interface that results in paralysis and poor clinical outcome after restorative surgery. Root reimplantation may decrease neuronal degeneration in such cases. We describe the use of a snake venom-derived fibrin sealant during surgical reconnection of avulsed roots at the spinal cord surface. The present work investigates the effects of this fibrin sealant on functional recovery, neuronal survival, synaptic plasticity, and glial reaction in the spinal motoneuron microenvironment after ventral root reimplantation.Methodology/Principal Findings:Female Lewis rats (7 weeks old) were subjected to VRA and root replantation. The animals were divided into two groups: 1) avulsion only and 2) replanted roots with fibrin sealant derived from snake venom. Post-surgical motor performance was evaluated using the CatWalk system twice a week for 12 weeks. The rats were sacrificed 12 weeks after surgery, and their lumbar intumescences were processed for motoneuron counting and immunohistochemistry (GFAP, Iba-1 and synaptophysin antisera). Array based qRT-PCR was used to evaluate gene regulation of several neurotrophic factors and receptors as well as inflammatory related molecules. The results indicated that the root reimplantation with fibrin sealant enhanced motor recovery, preserved the synaptic covering of the motoneurons and improved neuronal survival. The replanted group did not show significant changes in microglial response compared to VRA-only. However, the astroglial reaction was significantly reduced in this group.Conclusions/Significance:In conclusion, the present data suggest that the repair of avulsed roots with snake venom fibrin glue at the exact point of detachment results in neuroprotection and preservation of the synaptic network at the microenvironment of the lesioned motoneurons. Also such procedure reduced the astroglial reaction and increased mRNA levels to neurotrophins and anti-inflammatory cytokines that may in turn, contribute to improving recovery of motor function. © 2013 Barbizan et al.

Tratamento cirúrgico de condroma extradural lombar em cão - relato de caso

Neoplasms originating in the spinal canal are uncommon in small animal veterinary clinic, but when present can cause significant neurological signs. Anatomically, these neoplasms can be classified as extradural, intradural-extramedullary and medullary. Extradural neoplasms are located outside the dura mater, but they can cause compression of the spinal cord. The chondromas are benign neoplasms characterized by the formation of cartilage and is rarely located in the spinal canal in both human and veterinary medicine. We describe a case of lumbar extradural chondroma in a dog that surgical decompression and removal of the mass allowed the resolution of clinical signs of paralysis with return of function of the hind limbs of the patient.

Avaliação dos efeitos do inseticida imidacloprido para abelhas sem ferrão Scaptotrigona postica Latreille, 1807 (Hymenoptera, Apidae, Meliponini): Hellen Maria Soares. -

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Recuperação da função locomotora de cães com discopatia após cirurgia de fenestração discal tóraco-lombar: estudo retrospectivo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Comunicação suplementar e alternativa no discurso narrativo do aluno com paralisia cerebral

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Ação de compostos vegetais sobra a atividade da Piratoxina-I, isolada do veneno de Bothrops pirajai, em preparação neuromuscular de camundongos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Percepção da imagem corporal de adultos após acidente vascular encefálico: uma abordagem psicofísica

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Efeito do gliconato de cálcio e do nimodipino no tratamento de intoxicações agudas por tri-orto-cresil fosfato em galinhas

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Lesão do nervo fibular comum. Avaliação neuronal, muscular e funcional após neurotmese parcial: estudo no rato

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeito do glyphosate e sulfumeturon-metil na fisiologia da cana-de-açúcar

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estudo comparativo entre o bloqueio interescalênico do plexo branquial e o bloqueio seletivo dos nervos supraescapular e axilar nas cirurgias artroscópicas de ombro

Pós-graduação em Anestesiologia - FMB

Bioprospecção e caracterização químico-funcional de compostos orgânicos da baixas massas molecularesde venenos das vespas sociais: Agelaia pallipes pallipes, Agelaia vicina e Polybia paulista (Hymenoptera - Vespidae)

Pós-graduação em Ciências Biológicas (Biologia Celular e Molecular) - IBRC

Estudo analítico das endoscopias das vias aéreas de equinos PSI durante o período de 1993-2003 e avaliação dos resultados de procedimentos cirúrgicos laringeanos realizados no Jockey Club de São Paulo durante o período de 1998-2003

Pós-graduação em Medicina Veterinária - FMVZ

Estratégias de reparo utilizadas na substituição de segmento consonantal em portadores da síndrome de Moebius: uma análise otimalista

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)