Beryllium-7 sorption to inorganic particles in Tahsis Inlet, Nootka Sound, B.C.

Senior thesis written for Oceanography 445

Recent changes to the biogeochemistry of Muchalat Inlet, B.C., and the implications for HABs

Senior thesis written for Oceanography 445

Analysis of zooplankton species composition and depth-based habitat preference in Nootka Sound, B.C., Canada

Senior thesis written for Oceanography 445

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.

BACKGROUND & AIMS: Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of infected persons; approximately 50% of these do not respond to therapy. We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy. METHODS: The analysis included 1362 individuals: 1015 with chronic hepatitis C and 347 who spontaneously cleared the virus (448 were coinfected with human immunodeficiency virus [HIV]). Responses to pegylated interferon alfa and ribavirin were assessed in 465 individuals. Associations between more than 500,000 single nucleotide polymorphisms (SNPs) and outcomes were assessed by multivariate logistic regression. RESULTS: Chronic hepatitis C was associated with SNPs in the IL28B locus, which encodes the antiviral cytokine interferon lambda. The rs8099917 minor allele was associated with progression to chronic HCV infection (odds ratio [OR], 2.31; 95% confidence interval [CI], 1.74-3.06; P = 6.07 x 10(-9)). The association was observed in HCV mono-infected (OR, 2.49; 95% CI, 1.64-3.79; P = 1.96 x 10(-5)) and HCV/HIV coinfected individuals (OR, 2.16; 95% CI, 1.47-3.18; P = 8.24 x 10(-5)). rs8099917 was also associated with failure to respond to therapy (OR, 5.19; 95% CI, 2.90-9.30; P = 3.11 x 10(-8)), with the strongest effects in patients with HCV genotype 1 or 4. This risk allele was identified in 24% of individuals with spontaneous HCV clearance, 32% of chronically infected patients who responded to therapy, and 58% who did not respond (P = 3.2 x 10(-10)). Resequencing of IL28B identified distinct haplotypes that were associated with the clinical phenotype. CONCLUSIONS: The association of the IL28B locus with natural and treatment-associated control of HCV indicates the importance of innate immunity and interferon lambda in the pathogenesis of HCV infection.

500 cm3, Naas sur A.B.C. [critérium motocycliste de l'A.A.M.M., Association des anciens motocyclistes militaires à Auxerre, le 24 mai 1920] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59359

Plan du port de Carmen / par C.B. Matenas ; Lith. de Lenormand de l'Oisier

Échelle(s) : [ca 1:66 000], échelle de [4] milles [= 9,8 cm]

« Oeuvres sacrez de J. B. C. », à savoir.

Contient : 1 « Job ou de la fermeté,.VI. livres », traduction en vers du livre de Job ; 2 « Version des cantiques de l'Eglise » ; 3 « Le Symbole d'ATHANASE » ; 4 « Hymne de S. S. AMBROISE et AUGUSTIN » ; 5 « Le Cantique des cantiques, ou Les amours de Salomon et de Sulamite, avec l'allegorie des amours de Jesu Christ et de l'Eglise » ; 6 « Version du psaume 137, Super flumina Babylonis »