Identification of a biomarker panel for colorectal cancer diagnosis

Background:Malignancies arising in the large bowel cause the second largest number of deaths from cancer in the Western World. Despite progresses made during the last decades, colorectal cancer remains one of the most frequent and deadly neoplasias in the western countries. Methods: A genomic study of human colorectal cancer has been carried out on a total of 31 tumoral samples, corresponding to different stages of the disease, and 33 non-tumoral samples. The study was carried out by hybridisation of the tumour samples against a reference pool of non-tumoral samples using Agilent Human 1A 60-mer oligo microarrays. The results obtained were validated by qRT-PCR. In the subsequent bioinformatics analysis, gene networks by means of Bayesian classifiers, variable selection and bootstrap resampling were built. The consensus among all the induced models produced a hierarchy of dependences and, thus, of variables. Results: After an exhaustive process of pre-processing to ensure data quality--lost values imputation, probes quality, data smoothing and intraclass variability filtering--the final dataset comprised a total of 8, 104 probes. Next, a supervised classification approach and data analysis was carried out to obtain the most relevant genes. Two of them are directly involved in cancer progression and in particular in colorectal cancer. Finally, a supervised classifier was induced to classify new unseen samples. Conclusions: We have developed a tentative model for the diagnosis of colorectal cancer based on a biomarker panel. Our results indicate that the gene profile described herein can discriminate between non-cancerous and cancerous samples with 94.45% accuracy using different supervised classifiers (AUC values in the range of 0.997 and 0.955).

Análisis de elementos de madera reforzados con materiales compuestos

Gran parte del patrimonio construido cuenta con edificios cuya estructura está compuesta por elementos de madera. El volumen económico que supone el mantenimiento y renovación de dicho patrimonio es considerable, por ello, es de especial interés el estudio de las diferentes técnicas de refuerzo aplicables a este tipo de estructuras. Las estructuras de madera han sido tradicionalmente reforzadas con piezas del mismo material, aumentando la sección de los elementos dañados, o con acero. La aparición de los materiales compuestos de polímeros reforzados con fibras, y su progresiva aplicación en obras de construcción, hizo que a principios de la década de los noventa se comenzara a aplicar este material en refuerzos de estructuras de madera (Puente de Sins, 1992). La madera es un material natural con una excelente relación entre sus características mecánicas y su peso. Con el uso de materiales compuestos como refuerzo ésta característica se mantiene. En cuanto a su modelo constitutivo, se admite un comportamiento elástico lineal a tracción paralela a la fibra hasta la rotura, mientras que a compresión, se considera un comportamiento lineal elástico inicial, seguido de un tramo plástico. En vigas de madera aserrada sometidas a flexión predomina el modo de fallo por tracción localizándose la fractura frecuentemente en el canto inferior. Los FRP tienen un comportamiento elástico lineal a tracción hasta la rotura y cuentan con excelentes propiedades mecánicas en relación a su peso y volumen. Si se refuerza la viga por el canto inferior se aumentará su capacidad de absorber tracciones y por tanto, es previsible que se produzca un incremento en la capacidad de carga, así como un aumento de ductilidad. En este trabajo se analizan los beneficios que aportan distintos sistemas de refuerzos de materiales compuestos. El objetivo es contribuir al conocimiento de esta técnica para la recuperación o aumento de las propiedades resistentes de elementos de madera sometidos a flexión. Se ha llevado a cabo un estudio basado en datos obtenidos experimentalmente mediante el ensayo a flexión de vigas de madera de pino silvestre reforzadas con materiales compuestos. Las fibras que componen los tejidos utilizados para la ejecución de los refuerzos son de basalto y de carbono. En el caso de los compuestos de fibra de basalto se aplican en distintos gramajes, y los de carbono en tejido unidireccional y bidireccional. Se analiza el comportamiento de las vigas según las variables de refuerzo aplicadas y se comparan con los resultados de vigas ensayadas sin reforzar. Además se comprueba el ajuste del modelo de cálculo no lineal aplicado para predecir la carga de rotura de cada viga reforzada. Con este trabajo queda demostrado el buen funcionamiento del FRP de fibra de basalto aplicado en el refuerzo de vigas de madera y de los tejidos de carbono bidireccionales con respecto a los unidireccionales. ABSTRACT Many of the buildings of the built heritage include a structure composed by timber elements. The economic volume involved in the maintenance and renewal of this built heritage is considerable, therefore, the study of the different reinforcement techniques applicable to this type of structure is of special interest. The wooden structures have traditionally been reinforced either with steel or with pieces of the same material, increasing the section of the damaged parts. The emergence of polymer composites reinforced with fibers, and their progressive use in construction, started to be applied as reinforcement in timber structures at the beginning of the nineties decade in the 20th century (Sins Bridge, 1992). Wood is a natural material with an excellent ratio between its mechanic characteristics and its weight. This feature is maintained with the use of composites as reinforcement. In terms of its constitutive model, linear elastic behavior parallel to the fiber up to fracture is admitted when subjected to tensile stress, while under compression, an initial linear elastic behavior, followed by a section plasticizing, is considered. In sawn timber beams subjected to bending, the predominant failure is mainly due to tensile stress; and frequently the fracture is located at the beam lower face. The FRP have a linear elastic behavior until fracture occurs, and have excellent mechanical properties in relation to their weight and volume. If the beam is reinforced by its lower face, its capacity to absorb tensile stresses will increase, and therefore, an increase in its carrying capacity is likely to be produced, as well as an increase in ductility. This work analyzes the benefits different reinforcement systems of composite materials provide, with the aim of contributing to the knowledge of this technique for recovering or increasing the strength properties of timber elements subjected to bending loads. It is a study based on data obtained experimentally using bending tests of pine timber beams reinforced with composite materials. Fibers used for the execution of the reinforcement are basalt and carbon. Basalt fiber composites are applied in different grammages, whereas with carbon composites, unidirectional and bidirectional fabrics are used. The behavior of the beams was analyzed regarding the reinforcement variables applied, and the results are compared with those of the tested beams without reinforcement. Furthermore it has been proved adjunting the nonlinear calculation model applied to predict the failure load of each reinforced beam. This work proves the good behavior of fiber reinforce plastic (FRP) with basalt fiber when applied to timber beams, and that of bidirectional carbon fabrics as opposed to the unidirectional ones.

SANTIFICAR A JAVÉ UM ESTUDO DE ISAÍAS 8,11-15

Esta pesquisa visa analisar a mensagem de Javé transmitida através do profeta Isaías em meio à guerra siro-efraimita (734-732 a.C.), no tempo do rei Acaz. A primeira parte deste trabalho fornece uma panorâmica histórica da situação tanto internacional quanto nacional da nação de Judá. No meio de sinais de guerras, invasões estrangeiras, desolação e aumento de tributos que acarretam maior insegurança para os setores mais empobrecidos, Javé faz sua aposta pela vida de Israel. Através do oráculo profético mo stra um caminho que pode chegar a subverter a ordem de um injusto sistema político advindo do próprio pecado da nação de Israel. Neste texto, santificar a Javé é a trilha que pode livrar-lhes da queda e da destruição. Santificar a Javé significa cuidar e preservar a vida, especialmente dos mais desprotegidos. Isto implica optar conscientemente por uma nova ordem que garanta uma existência digna para todos e todas. O objetivo desta pesquisa é entender como o conceito de santificação salientado pelo profeta Isaías, na perícope (Is 8,11-15), pode ajudar-nos a superar os problemas cotidianos e fornecer-nos novas posturas éticas para enfrentar a vida, isto é um conceito de santificação que requer do engajamento com o povo, fundamentalmente com a população mais carente e necessitada atualmente. Por meio do trabalho exegético tentamos encontrar respostas escondidas entre palavras, termos e frases, procurando entender o texto em diálogo com a vida cotidiana de seu tempo e do nosso. Este estudo pretende providenciar subsídios para a leitura popular da Bíblia que está sendo realizada por muitos grupos nas igrejas e comunidades cristãs, que buscam novos caminhos, horizontes, sonhos e utopias para continuar a viver em meio de sociedades em crises e de tempos difíceis.(AU)

SANTIFICAR A JAVÉ UM ESTUDO DE ISAÍAS 8,11-15

Esta pesquisa visa analisar a mensagem de Javé transmitida através do profeta Isaías em meio à guerra siro-efraimita (734-732 a.C.), no tempo do rei Acaz. A primeira parte deste trabalho fornece uma panorâmica histórica da situação tanto internacional quanto nacional da nação de Judá. No meio de sinais de guerras, invasões estrangeiras, desolação e aumento de tributos que acarretam maior insegurança para os setores mais empobrecidos, Javé faz sua aposta pela vida de Israel. Através do oráculo profético mo stra um caminho que pode chegar a subverter a ordem de um injusto sistema político advindo do próprio pecado da nação de Israel. Neste texto, santificar a Javé é a trilha que pode livrar-lhes da queda e da destruição. Santificar a Javé significa cuidar e preservar a vida, especialmente dos mais desprotegidos. Isto implica optar conscientemente por uma nova ordem que garanta uma existência digna para todos e todas. O objetivo desta pesquisa é entender como o conceito de santificação salientado pelo profeta Isaías, na perícope (Is 8,11-15), pode ajudar-nos a superar os problemas cotidianos e fornecer-nos novas posturas éticas para enfrentar a vida, isto é um conceito de santificação que requer do engajamento com o povo, fundamentalmente com a população mais carente e necessitada atualmente. Por meio do trabalho exegético tentamos encontrar respostas escondidas entre palavras, termos e frases, procurando entender o texto em diálogo com a vida cotidiana de seu tempo e do nosso. Este estudo pretende providenciar subsídios para a leitura popular da Bíblia que está sendo realizada por muitos grupos nas igrejas e comunidades cristãs, que buscam novos caminhos, horizontes, sonhos e utopias para continuar a viver em meio de sociedades em crises e de tempos difíceis.(AU)

O DISCURSO AMBIENTAL JORNALÍSTICO, POLÍTICO E EMPRESARIAL EM ÂMBITO LOCAL: uma proposta de análise

Esta tese tem como tema principal o discurso ambiental local. Trata-se de uma proposta de análise, que pode ser aplicada a este tipo de discurso em qualquer localidade, e um estudo de caso, que aplicou a análise proposta na tese. O objetivo geral desta pesquisa foi analisar a informação local sobre meio ambiente veiculada por meio dos discursos jornalístico, político e empresarial, estabelecendo relações históricas, sociais e ideológicas do discurso ambiental que permeiam as três áreas em questão. A metodologia incluiu três fases: pesquisa bibliográfica e revisão de literatura sobre os principais conceitos levantados no trabalho; levantamento de discursos locais disponíveis na mídia para análise no estudo de caso; análise dos discursos a partir de protocolo elaborado com base na Análise do Discurso de linha francesa. O estudo de caso traz a análise do discurso ambiental no município de Frutal-MG, onde hoje estão em andamento várias pesquisas e projetos na área ambiental. A principal conclusão do trabalho confirma a hipótese da pesquisa de que a informação ambiental fruto dos discursos político, jornalístico e empresarial em âmbito local tem caráter predominantemente situacional, mercadológico e propagandístico, pouco focada em conscientizar e educar e com ênfase em interesses comerciais e eleitorais e na resolução de problemas emergenciais.

An Acceptance and Commitment Approach to Issues of Behavioral Health Care in Soldiers

For over a decade, the U.S. military has been engaged in two distinct, yet equally deadly conflicts: Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF). There are many physical and psychological effects of war necessitating the activation and interventions of a myriad of behavioral health professionals. The purpose of the paper was to understand how and if contemporary military culture may work to support or hinder application of an Acceptance and Commitment Therapy (ACT) approach to issues of psychological health among Soldiers. While the empirical research on efficacy with Soldiers is limited, a review of military culture revealed the promotion of rigid rule following, although effective in combat, influences the emotional control agenda and stigma while in garrison. However, empirical research demonstrating the clinical benefits and flexibility of ACT is rapidly emerging with civilian and Veteran populations. Suggested as a prevention technique utilized early in Soldier's training to increase psychological flexibility, ACT appears to demonstrate much promise in ameliorating the psychological consequences of war.

Ethnic Violence on Kenya's Periphery: Informal Institutions and Local Resilience in Conflict-Affected Communities

Deadly, inter-ethnic group conflict remains a threat to international security in a world where the majority of armed violence occurs not only within states but in the most ungoverned areas within states. Conflicts that occur between groups living in largely ungoverned areas often become deeply protracted and are difficult to resolve when the state is weak and harsh environmental conditions place human security increasingly under threat. However, even under these conditions, why do some local conflicts between ethnic groups escalate, whereas others do not? To analyze this puzzle, the dissertation employs comparative methods to investigate the conditions under which violence erupts or stops and armed actors choose to preserve peace. The project draws upon qualitative data derived from semi-structured interviews, focus group dialogues, and participant observation of local peace processes during field research conducted in six conflict-affected counties in Northern Kenya. Comparative analysis of fifteen conflict episodes with variable outcomes reveals the conditions under which coalitions of civic associations, including local peace committees, faith-based organizations, and councils of elders, inter alia, enhance informal institutional arrangements that contain escalation. Violence is less likely to escalate in communities where cohesive coalitions provide platforms for threat-monitoring, informal pact making, and enforcement of traditional codes of restitution. However, key scope conditions affect whether or not informal organizational structures are capable of containing escalation. In particular, symbolic acts of violence and the use of indiscriminant force by police and military actors commonly undermine local efforts to contain conflict. The dissertation contributes to the literatures on civil society and peacebuilding, demonstrating the importance of comparing processes of escalation and non-escalation and accounting for interactive effects between modes of state and non-state response to local, inter-ethnic group conflict.

Everyday Indivisibility: How Exclusive Religious Practices Explain Variation in Subnational Violence Outcomes

This project explores the puzzle of religious violence variation. Religious actors initiate conflict at a higher rate than their secular counterparts, last longer, are more deadly, and are less prone to negotiated termination. Yet the legacy of religious peacemakers on the reduction of violence is undeniable. Under what conditions does religion contribute to escalated violence and under what conditions does it contribute to peace? I argue that more intense everyday practices of group members, or high levels of orthopraxy, create dispositional indivisibilities that make violence a natural alternative to bargaining. Subnational armed groups with members whose practices are exclusive and isolating bind together through ritual practice, limit the acceptable decisions of leaders, and have prolonged timeframes, all of which result in higher levels of intensity, intransigence and resolve during violent conflict. The theory challenges both instrumentalist and constructivist understandings of social identity and violence. To support this argument, I construct an original cross-national data-set that employs ethnographic data on micro-level religious practices for 724 subnational armed groups in both civil wars and terror campaigns. Using this data, I build an explanatory “religious practice index” for each observation and examine its relationship with conflict outcomes. Findings suggest that exclusive practice groups fight significantly longer with more intensity and negotiate less. I also apply the practice model to qualitative cases. Fieldwork in the West Bank and Sierra Leone reveals that groups with more exclusive religious practicing membership are principle contributors to violence, whereas those with inclusive practices can contribute to peace. The project concludes with a discussion about several avenues for future research and identifies the practical policy applications to better identify and combat religious extremism.

La necesidad de considerar los riesgos climáticos en la introducción de cultivos tropicales en latitudes medias. El mango en el valle del Guadalhorce (Málaga)

El presente trabajo pretende demostrar que no es recomendable la introducción de un cultivo tropical como el mango (Mangifera indica) dentro del área mediterránea del valle del Guadalhorce (Málaga, España). Es un cultivo en expansión por su rentabilidad económica, pero es necesario atender a los posibles riesgos climáticos para su explotación (tras la gran inversión que requiere). Para justificar esta afirmación se presenta un estudio agroclimático realizado en las parcelas experimentales de la finca de IFAPA (Instituto de Investigación y Formación Agraria y Pesquera de Andalucía) de Churriana (Málaga). Los resultados se obtienen a través de los datos de una estación meteorológica y una modelización territorial a partir de herramientas de análisis espacial con SIG. Se tienen en cuenta las variables térmicas y los vientos como condicionantes principales de la aparición de la necrosis apical: patología mortal para el mango.

Ashakara

Set in Togo, West Africa, Ashakara is a modern African tale. An African doctor finds a cure to a deadly virus and decides to mass produce the drug at low cost in Africa. However, a pharmaceutical multinational does not want the doctor to succeed and sends an agent to Africa first to buy the drug then to destroy it ...

IV. Essay, undated

The undated handwritten essay begins, "I bles god that I have bene born under the gospel..." The essay is a two page personal exploration into Christianity and belief, including the sentences "I believe that there is one god in three persons father son and holy god. I believe that Jesus Christ is the son of god and that he look upon him our nature and came into the world and dyed a miserable and cruel death for the sins of the elect."

[ 12 grañthne 103 (101?) ginān

Pīr Imām Shāh, Pīr Sohodev, Pīr Shams, ... [et al.]].

Linfohistiocitose hemofagocítica secundária a infecção por epstein-barr a propósito de um caso clínico

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Saving Libya from itself: What the EU should do now. CEPS Commentary, 1 December 2014

Libya is experiencing its worst security crisis since the 2011 revolution, the intervention by NATO and the overthrow of Colonel Muammar Gaddafi. While the parliamentary elections of July 2012 provided “an opportunity to put the transition process back on track and overcome the recent political polarisation”, the country has instead descended into a deadly vortex of conflicting political groups, militias and tribes. Without the international political attention that is needed to save it from itself, Libya is now breaking up in at least two parts. Each faction is under pressure to declare its allegiance to the two biggest rival coalitions: either ‘Libyan Dignity’ or ‘Libyan Dawn’. The authors suggest that EU action take place on three levels.

EU Borders and Their Controls: Preventing unwanted movement of people in Europe? CEPS Essay No. 6, 14 November 2013

his Essay attempts to take a step back from the tragic event in the first week of October 2013, when a boat capsized off the Italian island of Lampedusa and some 300 persons drowned seeking safe harbour. It sets out to examine the issue of EU border controls from the perspectives of the technologies, new and old, building on a variety of scholarly disciplines to understand what is happening to border controls on the movement of persons in the EU and why the results are so deadly. The Essay opens with an overview of what actually happens at the EU’s external borders. It then moves on to assess the old and new set of border control technologies that are deployed at the EU external borders, and how new technologies such as those based on automated controls and biometrics, are transforming the classical principles of European border controls. It then covers the reasons why people are refused admission at the EU’s external borders and the extent to which new border and surveillance technologies would assist in the effective controls in light of EU border law. Conclusions are finally offered on the articulation between the facts of EU border controls on persons and the claims and proposals for new technologies that are emerging from the EU institutions.