A dramatic lung cancer course in a patient with a rare EGFR germline mutation exon 21 V843I: Is EGFR TKI resistance predictable?

We report on the medical history of a Caucasian smoker woman diagnosed with a stage IV NSCLC adenocarcinoma, characterized by a rare epidermal growth factor receptor (EGFR) point mutation in exon 21 codon 843 (p.V843I/c.2527G>A/COSMIC ID 85894). This genetic alteration revealed to be germline, after its presence was demonstrated in chondroblasts from the bone biopsy. While it is the first description of germline V843I mutation without concomitant additional known EGFR activating mutation, we modeled the EGFR ATP catalytic domain in complex with ATP, gefitinib and erlotinib using computer-aided approaches to estimate possible changes in affinity upon the V843I mutation.

[Costante] Girardengo [coureur cycliste italien disputant une course au vélodrome d'hiver le 7-12-19] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57116

[Orlando] Piani [coureur cycliste italien disputant une course au vélodrome d'hiver le 30-11-19] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57117

[W.] Douglas Hawkes sur AJS [750 cmc, concurrent de la course motocycliste Paris-Nice] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57954

[M.] Brunet [n°32], [E.] Grapperon [n°31], [J.] Pernette [n°30] sur Blériot [500 cmc, concurrents de la course motocycliste Paris-Nice] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57949

Fred Dover [ou Dove] sur Triumph [750 cmc, concurrent de la course motocycliste Paris-Nice] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57967

[W. H.] Greenwood [500 cmc, concurrent de la course motocycliste Paris-Nice] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57966

Delaunay sur Matchless [concurrent de la course motocycliste Paris-Nice] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57946

Une course [de patins à glace] à Davos (Suisse) : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57047

Change in defense mechanisms and coping over the course of short-term dynamic psychotherapy for adjustment disorder.

Short-term dynamic psychotherapy (STDP) has rarely been investigated with regard to its underlying mechanisms of change, even if psychoanalytic theory informs us about several potential putative mechanisms of change in patients. Change in overall defensive functioning is one. In this study, we explored the role of overall defensive functioning, by comparing it on the process level with the neighbouring concept of overall coping functioning. A total of N=32 patients, mainly presenting adjustment disorder, were included in the study. The patients underwent STDP up to 40 sessions; three sessions per psychotherapy were transcribed and analyzed by using two observer-rating scales: Defense Mechanism Rating Scales (Perry, 1990) and Coping Action Patterns (Perry, Drapeau, Dunkley, & Blake, 2005). Hierarchical linear modeling was applied to model the change over the course of therapy and relate it to outcome. Results suggest that STDP has an effect on the target variable of overall defensive functioning, which was absent for overall coping functioning. Links with outcome confirm the importance of the effect. These results are discussed from methodological and clinical viewpoints.

Vel d'hiv, 28/12/19, départ de la course des 50 kms, [Marcel] Berthet, [Emile] Aerts, [Jean] Alavoine : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57355

[J.] Newman, [F.] Rutherford, [Tom] Gillies sur Sunbeam [500 cmc, concurrents de la course motocycliste Paris-Nice] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57953

Georges Delaunay [n°39], Isodi [n°38], Felix Delaunay [n°127] sur Stucchi [concurrents de la course motocycliste Paris-Nice] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57964

d'Arcolo [ou d'Argollo] sur American Excelsior [1000 cmc, concurrent de la course motocycliste Paris-Nice] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57963