Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

Heme, iron (Fe) protoporphyrin IX, functions as a prosthetic group in a range of hemoproteins essential to support life under aerobic conditions. The Fe contained within the prosthetic heme groups of these hemoproteins can catalyze the production of reactive oxygen species. Presumably for this reason, heme must be sequestered within those hemoproteins, thereby shielding the reactivity of its Fe-heme. However, under pathologic conditions associated with oxidative stress, some hemoproteins can release their prosthetic heme groups. While this heme is not necessarily damaging per se, it becomes highly cytotoxic in the presence of a range of inflammatory mediators such as tumor necrosis factor. This can lead to tissue damage and, as such, exacerbate the pathologic outcome of several immune-mediated inflammatory conditions. Presumably, targeting "free heme" may be used as a therapeutic intervention against these diseases.

Cumner's son : and other South Sea folk /

Mode of access: Internet.

1977 UM Women's Tennis Team

U-M Softball Team, 2000

Front Row: Karmen Lappo, Jamie Gillies, Melissa Gentile (co-captain), Pam Kosanke (co-captain),

Second Row: Kate Eiland, Marissa Young, Courtney Murdock, Melinda Moulden, Meghan Doe, Marie Barda, Mary Conner.

Third Row: Liz Elsner, Chrissy Garza, Rebecca Tune, Kelsey Kollen, Stefanie Volpe,

Top Row: Melissa Taylor, Lisa Mack, Kim Bugel.

1990 University of Michigan Baseball Team

Top Row: groundskeeper Erich Keil, Chris Michalek, Scott Winterlee, Matt Copp, Bryan Santo, Ron Buff, Toby Brzoznowski, Eric Persinger, Derek Matthison, Joe Mooney, Pat Maloney, Scott Schorer, Scott Timmerman, student trainer Earl Wenk, student manager Kevin Lewis

Middle Row: trainer Kim Hart, grad. Asst. Ed Turek, asst. coach Ted Mahan, Todd Konuszewski, Mike Matheny, Dave Julier, Steve Buerkel, asst. coach Ace Adams, coach Moby Benedict

Front Row: Russell Brock, Jeff Tanderys, Da ruff, Brian Korson, Stacey Katlin, co-captain Phil Price, coach Bill Freehan, co-captain Kirt Ojala, Rick Leonard, Greg Haeger, Dave Everly, Matt Morse, Jason Pfaff

1991 University of Michigan Baseball Team

Top Row: groundskeeper Erich Keil, John Ellison, Kevin Crociata, Bubba Wyngarden, Chris Newton, Matt Copp, Scott Winterlee, Scott Timmerman, Brian Feldman, trainer Rex Thompson

Middle Row: grad. asst. Ed Turek, asst. coach Ted Mahan, Bryan Santo, Terry Woods, Toby Brzoznowski, Eric Persinger, Nate Holdren, Matt Idoni, Dennis Konuszewski, Eric Heintschel, Pat Maloney, asst. coach Ace Adams

Front Row: Andy Fairman, Russell Brock, Jason Pfaff, Tim Flannelly, Joe Mooney, Dan Ruff, coach Bill Freehan, Mike Matheny, Jeff Tanderys, Dave Everly, Steve Buerkel, Todd Winston, Todd Marion

1992 University of Michigan Baseball Team

Back Row: Student Manager Adam Rosen, Groundskeeper Erich Keil, Tony Agosta, Billy Hardy, Kevin Crociata, Ryan Van0everen, Jason Mahoney, Dan Weeks, Matt Humbles, Scott Niemiec, Todd Fracassi, Jasen Livingston, Rodney Goble, Trainer Rex Thompson.

Middle Row: Grad Assistant Ed Turek, Assistant Coach Dan O'Brien, Bubba Wyngarden, Aaron Toth, Heath Murray, Nate Holdren, Matt Idoni, Chad Chapman, Ron Hollis, Matt Copp, Chris Newton, Volunteer Coach Ernie Savas, Assistant Coach Ace Adams.

Front Row: (from left): Bryan Santo, Eric Heintschel, Chris Michalek, Terry Woods, Toby Brzoznowski, Todd Marion, Head Coach Bill Freehan, Steve Buerkel, Eric Persinger, Pat Maloney, Scott Winterlee, Scott Timmerman, Dennis Konuszewski.

1993 University of Michigan Baseball Team

Back Row: (10) Groundskeeper Erich Keil, Scott Niemiec, Scott Weaver, Mark Temple, Andy Wade, Brian Simmons, John Arvai, Matt Humbles, Student Manager Matt Hyde, Student Trainer Ann Whittenbach.

Middle Row: (12) Volunteer Assistant Coach Ed Turek, Jasen Livingston, Chris Newton, Heath Murray, Nate Holdren, Matt Ferullo, Ray Ricken, Chad Chapman, Sean Coston, Ryan Van Oeveren, Rodney Goble, Trainer Rex Thompson.

Front Row: (11) (from left): Assistant Coach Ace Adams, Toby Brzoznowski, Bryan Santo, Eric Heintschel, Co-Captain Todd Marion, Head Coach Bill Freehan, Co-Captain Scott Timmerman, Scott Winterlee, Matt Copp, Pat Maloney, Assistant Coach Dan O'Brien.

1976/1977 UM Women's Basketball Team

Back Row: head coach Carmel Borders, Terry Conlin, Linda Gardener, Kathryn Young, Karen Gilhooly, Sheila Butler, ass't coach Jane Bennett

Front Row: trainer Polly Germanout, Peggy Kopmeyer, Melinda Fertig, Carol Klomparens, Lydia Sims, Jeanmarie Otto, Denise Cameron, Laura Pierie

Safe driving knowledge dissemination and testing techniques. Volume I. General findings. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Safe driving knowledge dissemination and testing techniques: volume II: final report.

National Highway Traffic Safety Administration, Washington, D.C.

Safe driving knowledge dissemination and testing techniques. Volume III: handbook. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Assessment of vehicle safety problems for special driving populations. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Low fare and fare free transit : some recent applications by U.S. transit systems /

Mode of access: Internet.