Variação genética para compostos bioquímicos em sementes de duas populações naturais de Genipa americana L.: 1-análises individuais e univariada

Brazil is one of the world's richest countries in forest biodiversity. This has a great importance for humanity for sheltering essential scientific potential for the improvement in the quality of living beings. It also contributes to the preservation of natural resources and the environment. Among Brazil's forest species, jenipapo (Genipa americana L.) is commonly found in riparian vegetation. The objective of this work was to quantify the genetic variability of biochemical traits of seeds, as a support for in situ and ex situ conservation of natural populations of G. americana L. Two populations of the species were studied: one from Ilha Solteira, SP region (ISA) and other from Mogi Guaçu, SP (MOG). In the ISA population, seeds were collected from 30 trees, and in the MOG population, from 22 trees. These seeds were analyzed for chemical composition: content of proteins, carbohydrates, lipids and starch. The two populations of G. americana studied had a great genetic variation for these traits. The population ISA had an additive and phenotypic correlation, which was negative and high for starch with lipid; and positive and medium, for lipid with prolamine, as well as for globulin with prolamine. The population MOG presented additive and phenotypic correlations: positive and medium for gluteline with globulin. In these populations, narrow sense heritability estimates of progenies were moderate (0.69 for carbohydrates in the population ISA) to high (0.81 to 0.99 for the other traits in the two populations), indicating that much progress can be expected with selection strategies.

Planejamento, síntese e avaliação farmacológica de compostos híbridos potencialmente ativos para o tratamento da anemia falciforme

Sickle cell disease (SCD) is a hereditary hemolytic anemia caused by the inheritance of one S hemoglobin gene from each ancestor. Patients with SCD present increased circulating levels of cytokines, including TNF-alpha (TNF-α). Hydroxyurea (HU) is the available therapeutically strategy for treatment; it acts as a source of nitric oxide and benefits patients by increasing the levels of fetal hemoglobin (HbF). Thus, within one research line that aims at finding new drugs, a series of compounds with TNF-α inhibition and nitric oxide donation properties have been synthesized in order to explore possible synergism of actions beneficial in the treatment of the disease. Six compounds were synthesized: five derivatives of organic nitrates and one of sulfonamide. The compounds, (1,3-dioxo-1,3-dihydro-2Hisoindol-2-yl) methyl nitrate (compound I); (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) ethyl nitrate (compound II); 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound III);4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxybenzenesulfonamide (compound IV); 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound V) and 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) phenyl]ethyl nitrate (compound VI), were synthesized using linear synthetic methodology, with excellent overall yields. All compounds showed anti-inflammatory and analgesic effects with a reduction in 43%-65% of ear edema in mice and a reduction of 25%-42% of writhing induced by acetic acid. All compounds showed comparable reductions in the leukocyte infiltration capacity and ability to generate nitric oxide. The aryl compounds (III, IV and V) presented less mutagenic activity compared to compounds I, II and VI according to the salmonella mutagenicity assay (Ames test). Compounds IV and VI showed activity in K562 culture cells, with increases in gamma globin gene expression to levels higher than with hydroxyurea suggesting a potential to increase fetal hemoglobin. This data set characterizes new potentially useful drug candidates for the treatment of symptoms of sickle cell anemia.

Contribuição ao estudo bioquímico de polpa de híbridos da cultivar maracujá amarelo azedo (Passiflora edulis f. flavicarpa Degener): enzimas e compostos bioativos

Pós-graduação em Biotecnologia - IQ

Transformação do glicerol em compostos de interesse petroquímico catalisada por zeólitas com ordem hierárquica de poros

Pós-graduação em Química - IQ

Efeito da lisina na produção de compostos beta-lactâmicos produzidos por Sterptomuces clavuligerus

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Compostos fenólicos e atividade antioxidante em Salvia officinalis L. micropropagada

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudos sobre a síntese de piperidinas funcionalizadas através de reações pentacomponentes, utilizando compostos de nióbio como catalisadores

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Compostos orgânicos como substratos na formação de mudas de ipê amarelo [Tabebuia chrysotricha (Mart. ex DC) Standl.] irrigado com água residuária

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Compostos voláteis da uvaia (Eugenia pyriformis cambess)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito do processamento industrial para obtenção de goiabada sobre os compostos antioxidantes e cor

Pós-graduação em Alimentos e Nutrição - FCFAR

Fases magnéticas em compostos Er'Co IND. x''Mn IND. 1-x''O IND> 3+ou - δ'

Pós-graduação em Ciência e Tecnologia de Materiais - FC

Investigação comparativa das propriedades estruturais do diboreto de magnésio dopado com compostos de carbono

Pós-graduação em Ciência e Tecnologia de Materiais - FC

Atividade antibacteriana de óleos essenciais de especiarias em alimentos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo das propriedades supercondutoras e da microestrutura do supercondutor Mg'B IND. 2' puro e dopado com compostos de carbono

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Docking e análise do modo de ligação de três moléculas pequenas, um benzimidazol e dois compostos de crômio, nos sulcos do DNA 5'-CGCGAATTCGCG-3

Pós-graduação em Ciência e Tecnologia de Materiais - FC