Letter to Mr. B. Allan from Burrow, Chatfield and Co.

Letter to Mr. B. Allan from Burrow, Chatfield and Co. saying that they will put together all the gas fixtures, Sept. 22, 1876.

Receipt from Burrow, Chatfield and Co. of St. Catharines

Receipt from Burrow, Chatfield and Co. of St. Catharines for plumbing and metal supplies, Aug. 23, 1876.

Receipt from Burrow, Chatfield and Co. for plumbing

Receipt from Burrow, Chatfield and Co. for plumbing, Oct. 23, 1876.

Receipt from Chatfield and Neelon, Specialties, Steamboat Work and Engineers’ Supplies, St. Catharines

Receipt from Chatfield and Neelon, Specialties, Steamboat Work and Engineers’ Supplies, St. Catharines for various fittings, March 31, 1887.

Receipt from Chatfield and Neelon, St. Catharines for various fittings and pipes

Receipt from Chatfield and Neelon, St. Catharines for various fittings and pipes, May 13, 1887.

Receipt from Chatfield and Neelon, St. Catharines for freezer, glass globe and fixtures

Receipt from Chatfield and Neelon, St. Catharines for freezer, glass globe and fixtures, July 1, 1887.

Receipt from Chatfield and Neelon, St. Catharines for cleaning out boilers

Receipt from Chatfield and Neelon, St. Catharines for cleaning out boilers, Oct. 1, 1887.

An Efficient Multi-component Synthesis of 6-Amino-3-methyl-4-Aryl-2,4- dihydropyrano[2,3-c]Pyrazole-5-carbonitriles

Multi-component reactions are effective in building complex molecules in a single step in a minimum amount of time and with facile isolation procedures; they have high economy1–7 and thus have become a powerful synthetic strategy in recent years.8–10 The multicomponent protocols are even more attractive when carried out in aqueous medium. Water offers several benefits, including control over exothermicity, and the isolation of products can be carried out by single phase separation technique. Pyranopyrazoles are a biologically important class of heterocyclic compounds and in particular dihydropyrano[2,3-c]pyrazoles play an essential role in promoting biological activity and represent an interesting template in medicinal chemistry. Heterocyclic compounds bearing the 4-H pyran unit have received much attention in recent years as they constitute important precursors for promising drugs.11–13 Pyrano[2,3-c]pyrazoles exhibit analgesic,14 anti-cancer,15 anti-microbial and anti-inflammatory16 activity. Furthermore dihydropyrano[2,3-c]pyrazoles show molluscidal activity17,18 and are used in a screening kit for Chk 1 kinase inhibitor activity.19,20 They also find applications as pharmaceutical ingredients and bio-degradable agrochemicals.21–29 Junek and Aigner30 first reported the synthesis of pyrano[2,3-c]pyrazole derivatives from 3-methyl-1-phenylpyrazolin-5-one and tetracyanoethylene in the presence of triethylamine. Subsequently, a number of synthetic approaches such as the use of triethylamine,31 piperazine,32 piperidine,33 N-methylmorpholine in ethanol,34 microwave irradiation,35,36 solvent-free conditions,37–39 cyclodextrins (CDs),40 different bases in water,41 γ -alumina,42 and l-proline43 have been reported for the synthesis of 6-amino-4-alkyl/aryl-3-methyl- 2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles. Recently, tetraethylammonium bromide (TEABr) has emerged as mild, water-tolerant, eco-friendly and inexpensive catalyst. To the best of our knowledge, quaternary ammonium salts, more specifically TEABr, have notbeen used as catalysts for the synthesis of pyrano[2,3-c]pyrazoles, and we decided to investigate the application of TEABr as a catalyst for the synthesis of a series of pyrazole-fused pyran derivatives via multi-component reactions

La m??sica en el Caf??-Teatro Recreo : C??rdoba 1865-1874

Resumen en ingl??s. Resumen basado en el de la publicaci??n

C. H. Chalmers.- Bacteriología de la leche. (Bacteria in relation to the milk supply). 271 pp., 3ª ed., 1945, reimpresa en 1949. Editado por Edward Arnol & Co., Londres

Fil: H. G. C..

Prof. C. Haussknecht's Routen im Orient 1865-1869: III. Kurdistan und Irak

nach dessen Originalskizzen redigirt von H. Kiepert.

Historical sketch of the Pee Dee Guards (Co. D, 23d N.C. Regiment) from 1861 to 1865 /

Reprint. Originally published: Raleigh, N.C. : Edwards, Broughton & Co., 1876.

Specifications for bituminous road-mix surface dense-graded aggregate type, subclass C-1 : effective June 1, 1945.

Reproduced from typewritten copy.