Structural insights into substrate binding of brown spider venom class II phospholipases D

Phospholipases D (PLDs), the major dermonecrotic factors from brown spider venoms, trigger a range of biological reactions both in vitro and in vivo. Despite their clinical relevance in loxoscelism, structural data is restricted to the apo-form of these enzymes, which has been instrumental in understanding the functional differences between the class I and II spider PLDs. The crystal structures of the native class II PLD from Loxosceles intermedia complexed with myo-inositol 1-phosphate and the inactive mutant H12A complexed with fatty acids indicate the existence of a strong ligand-dependent conformation change of the highly conserved aromatic residues, Tyr 223 and Trp225 indicating their roles in substrate binding. These results provided insights into the structural determinants for substrate recognition and binding by class II PLDs.

(Table 1, page 146) Iron, manganese and nickel contents of 21 ferromanganese nodules from Combe D'Izame and Mont Peyroux, Montagne Noire

Ferromanganese nodules (equivalent to Recent manganese nodules) are described from the Upper Devonian griotte (red pelagic limestone) of the Montagne Noire (S. France) and the Cephalopodenkalk of the Rheinisches Schiefergebirge, West Germany. They occur as encrustations, commonly exhibiting colloform structures, around skeletal material and limestone clasts. The nodules are associated with encrusting foraminifera and a development in the sublittoral environment is envisaged. Chemically, the ferromanganese nodules are depleted in manganese relative to iron, compared with Recent nodules, a loss which is attributed to diagenetic migration of manganese. Electron probe studies show that manganese covaries positively with calcium, but negatively with iron and silicon. Diagenetic enrichment of hematite occurs in the griotte at hardground horizons where two periods of mineralization can be established. The Devonian ferromanganese nodules show that solution of nodules has not occurred on burial.

Catharine Waugh McCullouch papers in the Mary Earhart Dillon collection, 1869-1945

Collection primarily documents McCulloch's research on women's legal status, and her work with the Illinois Equal Suffrage Association, the National American Woman Suffrage Association, and the League of Women Voters. There is also documentation of women in the legal profession, of McCulloch's friendships with the other women suffragists and lawyers, and some biographical material. The papers contain little information about her family or social life.

A memorial discourse of Nathaniel F. Moore, LL.D. : sometime president of Columbia College, New York, delivered at the request of the alumni, January 14, 1874, in the college chapel /

Published by direction of the alumni and of the board of trustees.

Autobiography of Mary Antoinette Doolittle prior to becoming a member of the Shaker community at New Lebanon, N.Y., in the year 1824.

Cf. MacLean, J.P. Shaker lit., 214.

George Henry Moore, L.L.D. : a memoir /

Mode of access: Internet.

Histoire d'Haïti (île de Saint-Domingue), depuis sa découverte jusqu'en 1824, époque des derniéres négociations entre la France et le gouvernement haïtien.

Mode of access: Internet.

Essai de biographie historique et psychologique: Maine de Biran (1766-1824), d'apres de nombreux documents inédits;

"Bibliographie: p. [531]-536.

P. F. C. Mary Brown, a WAC musical revue.

Libretto and production hints, condensed score, piano-conductor score and parts.

Discurso sobre la incertidumbre y perjuicios del sistema del doctor Juan Brown, con una breve respuesta a las reflexiones de D. Juan Bautista Llopis /

Mode of access: Internet.

Nominations of Mary Schapiro, Christina D. Romer, Austan D. Goolsbee, Cecilia E. Rouse, and Daniel K. Tarullo : hearing before the Committee on Banking, Housing, and Urban Affairs, United States Senate, One Hundred Eleventh Congress, first session, on nominations of Mary Schapiro, of New York, chairman-designate, Securities and Exchange Commission; Christina D. Romer, of California, chairman-designate, Council of Economic Advisors; Austan D. Goolsbee, of Illinois, member-designate, Council of Economic Advisors; Cecilia E. Rouse, of New Jersey, member-designate, Council of Economic Advisors; Daniel K. Tarullo, of Maryland, member-designate, Board of Governors of the Federal Reserve System, January 15, 2009.

Shipping list no.: 2009-0407-P.

Exposition d'un systême plus simple de médecine, ou Éclaircissement et confirmation de la nouvelle doctrine médicale de Brown; traduite d'après l'édition italienne et les notes de Joseph Franck ... Par J. B. F. Léveillé ...

Mode of access: Internet.