Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytes

Propolis is a beehive product used in traditional medicine due to its biological properties. It shows a complex chemical composition including phenolics, such as cinnamic acid (Ci). The mechanisms of action of propolis have been the subject of research recently; however, the involvement of Ci on propolis activity was not investigated on immune cells. Ci effects were evaluated on human monocytes, assessing the expression of Toll-like receptors (TLRs), HLA-DR, and CD80. Cytokine production (TNF-α and IL-10) and the fungicidal activity of monocytes were evaluated as well. Data showed that Ci downregulated TLR-2, HLA-DR, and CD80 and upregulated TLR-4 expression by human monocytes. High concentrations of Ci inhibited both TNF-α and IL-10 production, whereas the same concentrations induced a higher fungicidal activity against Candida albicans. TNF-α and IL-10 production was decreased by blocking TLR-4, while the fungicidal activity of monocytes was not affected by blocking TLRs. These results suggest that Ci modulated antigen receptors, cytokine production, and the fungicidal activity of human monocytes depending on concentration, and TLR-4 may be involved in its mechanism of action. Ci seemed to be partially involved in propolis activities. © 2013 Bruno José Conti et al.

Peircean semiotics and subject indexing: Contributions of speculative grammar and pure logic

The semiotics of C S. Peirce presents fundamental concepts to discover aspects of the indexing process, including representation and classes of signs. However, we still know little of its theoretical potential for subject indexing. We believe that the main difficulty in the proposals to understand the process of subject indexing based on Peircean semiotics stems from an incomplete interpretation of his semiotic system. This paper attempts to describe the contributions of Peircean semiotics to subject indexing. First, we analyze some of the concepts of the branches of semiotics, after which, we discuss strategies for conceptual approximation. Secondly, and aiming to raise the level of interlocution between the areas, we intend to argue that subject indexing is an inferential process, as explained by the second branch of semiotics. Thus, we seek to go beyond the level of speculative grammar, the first branch of semiotics, to forge a closer link with pure or critical logic, the second branch. We conclude that the indexer's work does not produce a mere reflection of what already exists in documents, but involves an instigating action to discover, through the inferential matrix, the meaning of a text in order to find the subject and the most appropriate subject added entry to the information system.

Biogeografia histórica do gênero Brachygastra Perty, 1833 (Hymenoptera: Vespidae: Polistinae: Epiponini)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Distribuição intragástrica de refeições com 60 ml e 180 ml: três segmentações proximal-distal empregando a cintilografia

Pós-graduação em Biologia Geral e Aplicada - IBB

Indicadores sobre la situación de la infancia en América Latina y el Caribe = Indicators on the situation of children in Latin America and the Caribbean

Asistente de Investigación Eliana Barraza, traducción de Marjorie Casassus

Isolation and characterization of equine peripheral blood-derived multipotent mesenchymal stromal cells

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Equine mesenchymal stem cells from bone marrow, adipose tissue and umbilical cord: immunophenotypic characterization and differentiation potential

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Bone marrow mesenchymal stem cells stimulated by bFGF up-regulated protein expression in comparison with periodontal fibroblasts in vitro

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Le rêve qu’on appelle nous: sujeito e linguagem em L’Homme approximatif de Tristan Tzara

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Evaluation of mesenchymal stem cell migration after equine tendonitis therapy

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The immunomodulatory effect of propolis on receptors expression, cytokine production and fungicidal activity of human monocytes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Phenotypic and functional evaluations of peripheral blood monocytes from chronic-form paracoccidioidomycosis patients before and after treatment

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Oferta educacional em creches: análise das parcerias público-privadas nos municípios paulistas com mais de 500.000 habitantes

Este trabalho tem por tema os contornos institucionais gerados nas parcerias entre os setores público e privado na oferta educacional em creches nos municípios paulistas com mais de 500.000 habitantes, classificados como muito grandes e metropolitanos no Censo de 2000. Para isto, fez-se necessário identificar, caracterizar e analisar os contornos que vêm sendo gerados a partir dos convênios firmados entre o Poder Público Municipal e instituições privadas para oferta educacional em creches. O período considerado para o presente estudo foi entre 2000 e 2009. O início do período em 2000 se justifica pelo prazo final estabelecido pela LDB 9394/96, para integração das creches aos respectivos sistemas de ensino ser dezembro de 1999. Já o término do período em 2009 possibilita identificar alterações nas matrículas em creches após a instituição do FUNDEB. Assim, utilizamos como procedimento teórico-metodológico o levantamento e análise bibliográfica, contatos telefônicos diretos com os gestores municipais para coletar informações sobre as parcerias, dados disponibilizados no Banco de Dados do Grupo de Estudos e Pesquisas em Política Educacional (Greppe), sites oficiais dos municípios e sites governamentais. Constitui-se, este trabalho, como parte integrante da pesquisa “Oferta Educacional nas creches: Arranjos Institucionais entre o Público e o Privado” financiada pelo CNPq e coordenada pela Profª Drª Raquel Fontes Borghi. O estudo realizado nos permitiu identificar e analisar diferentes arranjos institucionais gerados entre o Poder Público Municipal com instituições privadas. Também, permitiu observar, que após a implantação do FUNDEB, a tendência nas matrículas é de crescimento nas creches, tanto na rede pública quanto na rede privada, e nas préescolas da rede privada. Já nas pré-escolas municipais a tendência é de oscilação nas matrículas

Morphology of Richards' gland in the swarm-founding wasp (Hymenoptera, Vespidae)

Richards' gland is known for the majority of Epiponini wasps, and despite few experimental evidences, the taxonomic distribution in swarm-founder species and the function of this gland remain rather unclear. This work presents a morphological description of Richards' gland in Protonectarina sylveirae. The gland is formed by a cluster of class 3 cells underneath the anterior margin of the fifth metasomal sternite, and a reservoir formed by the intersegmental membrane between the fourth and fifth metasomal sternites where the secretion can be stored. The secretory cells contain a branched end apparatus that carries the secretory products towards the duct cell. Externally, the cuticle of the sternite, where the duct cells penetrate, is characterized by modifications as scales with very numerous pores. The presence of Richards' gland according to the model proposed by Samacá et al. 2013 in Protonectarina corroborates the single origin of this gland in Epiponini. The occurrence of a Golgi apparatus and smooth endoplasmic reticulum suggests pheromone production.