Agricolan omituiset orientappurat

Summary: Agricola's peculiar orientappurat ('Thorns')

Aika ja oikeustiede

Oikeustieteen päivät 20.-21.12.1996

Low-dose cidofovir for the treatment of polyomavirus-associated nephropathy: two case reports and review of the literature.

BACKGROUND: Polyomavirus-associated nephropathy (PVAN) is a serious complication and cause of graft loss in kidney transplant recipients. In the absence of specific antiviral drugs, early detection of the disease and reduction of immunosuppressive regimen is the cornerstone of therapy. Cidofovir, a nucleoside analogue, has been found to inhibit BK virus (BKV) replication in vitro and has been proposed as treatment of refractory PVAN at low doses; however, its efficacy has never been demonstrated in randomized controlled trials. METHODS: Cidofovir therapy (0.5 mg/kg at a 2-week interval for eight consecutive doses) was initiated in two patients with biopsy-proven PVAN and persistent BKV DNA viraemia (> or = 10,000 copies/ml despite sustained reduction of the immunosuppressive regimen). In addition to these two case reports, we performed a critical review of the literature on the use of cidofovir in PVAN. RESULTS: No significant decrease of BKV viral load in blood was observed during cidofovir therapy and in follow-up of the two patients treated with cidofovir. Our literature review identified 21 publications reporting the use of cidofovir for the treatment of PVAN. All were case reports or small series. The efficacy of cidofovir therapy could not be assessed in 17 of these publications because of lack of data or concomitant reduction of immunosuppressive regimen. The four remaining publications were case reports. CONCLUSIONS: In vitro and clinical data to support the efficacy of cidofovir in the treatment of PVAN are currently lacking. More promising compounds should be identified for further clinical studies.

Oikeusterminologiaa keskiajalta

Zusammenfassung: Rechtsterminologie aus dem Mittelalter

Taidhacos somen kielen?

Vastine Pirkko Forsman Svenssonin artikkeliin // Virittäjä 1/1999, ja Osmo Ikolan artikkeliin // Virittäjä 1994

Finlandssvensk språknormering - lingvistik, sociologi eller politik?

Kirjoitus perustuu esitelmään, joka pidettiin Kotikielen Seuran, Hugo Bergroth -sällskapetin, Helsingin yliopiston suomen kielen laitoksen ja Nordican järjestämässä symposiumissa Mitä on hyvä kieli? - Om språkvård och språknorm 9.-10.2.1996

Kirjallisuutta

Pääosa virallisen vastaväittäjän prof. Mikael Hidénin Helsingin yliopiston oikeustieteelliselle tiedekunnalle antamasta 18.1.1999 päivätystä lausunnosta