Light vehicle antilock brake research program. Report 1 - evaluation of an electronic four sensor, three circuit integrated system. Final report.

Mode of access: Internet.

Light vehicle antilock brake research program. Report 2 - evaluation of a fully mechanical, two circuit, two sensor system. Final report.

Mode of access: Internet.

Laboratory measurement of vehicle characteristics for predicting highway behavior. Final report.

Federal Highway Administration, Washington, D.C.

Recent international activity in cooperative vehicle-highway automation systems /

This report summarizes the current state of the art in cooperative vehicle-highway automation systems in Europe and Asia based on a series of meetings, demonstrations, and site visits, combined with the results of literature review. This review covers systems that provide drivers with a range of automation capabilities, from driver assistance to fully automated driving, with an emphasis on cooperative systems that involve active exchanges of information between the vehicles and the roadside and among separate vehicles. The trends in development and deployment of these systems are examined by country, and the similarities and differences relative to the U.S. situation are noted, leading toward recommendations for future U.S. action. The Literature Review on Recent International Activity in Cooperative Vehicle-Highway Automation Systems is published separately as FHWA-HRT-13-025.

Literature review on recent international activity in cooperative vehicle-highway automation systems /

This literature review supports the report, Recent International Activity in Cooperative Vehicle-Highway Automation Systems. It reviews the published literature in English dating from 2007 or later about non-U.S.-based work on cooperative vehicle-highway automation systems. This review covers work performed in Europe and Japan, with application to transit buses, heavy trucks, and passenger cars. In addition to fully automated driving of the vehicles (without human intervention), it also covers partial automation systems, which automate subsets of the total driving process. Recent International Activity in Cooperative Vehicle Highway Automation Systems is published separately as FHWA-HRT-12-033.

Using an outflow meter to predict braking traction speed gradients as a function of surface tension. Technical report.

Mode of access: Internet.

Highway-vehicle-object simulation model - 1976. Volume 2: programmers manual. Final report.

Federal Highway Administration, Washington, D.C.

Highway-vehicle-object simulation model - 1976. Volume 3: engineering manual - analysis. Final report.

Federal Highway Administration, Washington, D.C.

Highway-vehicle-object simulation model - 1976. Volume 4: engineering manual - validation. Final report.

Federal Highway Administration, Washington, D.C.

Overweight vehicles: penalties and permits. An inventory of state practices for fiscal year 1992. Report to the United States Congress from the Secretary of Transportation pursuant to Section 123 of the Surface Transportation Assistance Act of 1978.

Mode of access: Internet.

Highway-vehicle-object simulation model - 1976. Volume 1: users manual. Final report.

Federal Highway Administration, Washington, D.C.

Effectiveness of alternative skid reduction measures - volume IV: criteria for improvement of pavement surface macrotexture. Final report.

Federal Highway Administration, Office of Research and Development, Washington, D.C.

Effects of vehicle and region of application on absorption of hydrocortisone through canine skin

Objective-To determine the effects of various vehicles on the penetration and retention of hydrocortisone applied to canine skin. Sample Population-20 canine skin samples obtained from the thorax, neck, and groin regions of 5 Greyhounds. Procedure-Skin was harvested from dogs after euthanasia and stored at -20 degrees C until required. The skin was then defrosted and placed into diffusion cells, which were maintained at approximately 32 degrees C by a water bath. Saturated solutions of hydrocortisone that contained trace amounts of radiolabelled [C-14]-hydrocortisone in each vehicle (ie, PBS solution [PBSS] alone, 50% ethanol [EtOH] in PBSS [wt/wt], and 50% propylene glycol in PBSS [wt/wt]) were applied to the outer (stratum corneum) surface of each skin sample, and aliquots of receptor fluid were collected for 24 hours and analyzed for hydrocortisone. Results-The maximum flux of hydrocortisone was significantly higher for all sites when dissolved in a vehicle containing 50% EtOH, compared with PBSS alone or 50% propylene glycol, with differences more prominent in skin from the neck region. In contrast, higher residues of hydrocortisone were found remaining within the skin when PBSS alone was used as a vehicle, particularly in skin from the thorax and neck. Conclusions and Clinical Relevance-Penetration of topically applied hydrocortisone is enhanced when EtOH is used in vehicle formulation. Significant regional differences (ie, among the thorax, neck, and groin areas) are also found in the transdermal penetration and skin retention of hydrocortisone. Variability in clinical response to hydrocortisone can be expected in relation to formulation design and site of application.

Vehicle effects on the in vitro penetration of testosterone through equine skin

The effects of three vehicles, phosphate-buffered saline (PBS), ethanol (50% in PBS w/w) and propylene glycol (50% in PBS w/w) on in vitro transdermal penetration of testosterone was investigated in the horse. Skin was harvested from the thorax of five Thoroughbred horses after euthanasia and stored at -20 degrees C until required. The skin was then defrosted and placed into Franz-type diffusion cells, which were maintained at approximately 32 degrees C by a water bath. Saturated solutions of testosterone, containing trace amounts of radiolabelled [C-14]testosterone, in each vehicle were applied to the outer (stratum corneum) surface of each skin sample and aliquots of receptor fluid were collected at 0, 2, 4, 8, 16, 20, 22 and 24 h and analysed for testosterone by scintillation counting. The maximum flux (J(max)) of testosterone was significantly higher for all sites when testosterone was dissolved in a vehicle containing 50% ethanol or 50% propylene glycol, compared to PBS. In contrast, higher residues of testosterone were found remaining within the skin when PBS was used as a vehicle. This study shows that variability in clinical response to testosterone could be expected with formulation design.

The effects of vehicle and region of application on in vitro penetration of testosterone through canine skin

The effects of the vehicles phosphate-buffered saline (PBS), ethanol (EtOH; 50% in PBS w/w) and propylene glycol (PG; 50% in PBS w/w) and the region of administration on in vitro transdermal penetration of testosterone was investigated in the dog. Skin was harvested from the thorax, neck (dorsal part) and groin regions of greyhounds after euthanasia and stored at -20 degrees C until required. The skin was then de-frosted and placed into Franz-type diffusion cells which were maintained at approximately 32 degrees C by a water-bath. Saturated solutions of testosterone, containing trace amounts of radiolabelled (C-14) testosterone, in each vehicle were applied to the outer (stratum corneum) surface of each skin sample and aliquots of receptor fluid were collected at 0, 2, 4, 8, 16, 20, 22 and 24 h and analysed for testosterone by scintillation counting. The maximum flux (J(max)) of testosterone was significantly higher for all sites when dissolved in a vehicle containing 50% EtOH or 50% PG, compared to PBS. In contrast, higher residues of testosterone were found remaining within the skin when PBS was used as a vehicle. This study shows that variability in percutaneous penetration of testosterone could be expected with formulation design and site of application. (C) 2004 Elsevier Ltd. All rights reserved.