HIV type-1 infection of the cotton rat (Sigmodon fulviventer and S. hispidus)

Cotton rats (Sigmodon hispidus and S. fulviventer) are susceptible to many viruses that infect humans (e.g., poliovirus, respiratory syncytial virus, influenza virus, adenovirus, and parainfluenza virus) and have been influential in developing therapeutic clinical intervention strategies for many viral infections of man. This study set out to determine whether cotton rats are susceptible to infection with HIV type 1 (HIV-1). Results indicate that HIV-1 does infect the cotton rat and S. fulviventer is more susceptible than S. hispidus. The virus was passaged from animal to animal for a total of three serial passages; but HIV replicated poorly in vivo, was only detectable as proviral DNA, and never exceeded one provirus per 1.8 × 105 cotton rat peripheral blood mononuclear cells. Infection induced a distinct and characteristic anti-HIV antibody response that, in some animals, included neutralizing antibodies, recognized all of the major HIV-1 antigens and the antibodies lasted out to 52 wk post-infection. Neonate S. fulviventer were not more susceptible to infection than adults. In vitro culture studies produced indirect evidence of viral replication by detection of viral gag gene RNA in reverse transcriptase–PCR assays on viral culture supernatants. Collectively, these results indicate that HIV-1 can replicate in a nontransgenic rodent and that this system may have potential as an animal model for HIV-1 infection if viral replication rates can be improved in vivo.

Mathematics notebook, ca. 1714-1718, with chronology of the reign of Augustus

The first two pages of this notebook contain a comparative chronology of the reign of Augustus, outlined in two columns. One column outlines the chronology according to ecclesiastical scholar Laurence Echard, and the other column outlines the chronology according to William Cave. The rest of the notebook contains extensive entries on the following subjects, with related rules, problems, and illustrations: fractions, decimals, arithmetical progression, geometrical progression, "disjunct proportion, or ye Golden Rule," signs and symbols, integers, geometrical definitions, and Euclidian geometry.

Notebook describing scholars' and church fathers' accounts of the Resurrection, undated

This notebook contains prose entries about many different scholars' accounts of Jesus Christ's Resurrection. Prince apparently studied over fifty authors' writings concerning the Resurrection and recorded in this notebook what he considered to be the significant details of each authors' interpretation.

A letter to the Right Honourable the Earl of Carnarvon, principal secretary of state for the colonies ; in reply to a Pamphlet entitled Confederation, considered in relation to the Interests of the Empire /

p. [3]-64: A letter to the Right Honourable the Earl of Carnarvon, principal secretary of state for the colonies; p. 65-78: Report of resolutions adopted at a conference of delegates from the provinces of Canada, Nova Scotia and New Brunswick, and the colonies of Newfoundland and Prince Edward Island, held at the city of Quebec, 10th October, 1864, as the basis of a proposed confederation of those provinces and colonies

Portrait of William I, Prince of Orange

Adriaen Thomasz Key; 1 ft. 6 57/64 in.x 1 ft. 1 25/64 in.; oil on panel

Minnesota and its resources : to which are appended Camp-fire sketches, or, Notes of a trip from St. Paul to Pembina and Selkirk settlement on the Red River of the north /

Advertisements on front end-paper and fly-leaf.

Journal of the Society for Army Historical Research.

Part of the illustrative material is folded, part colored.

The works of Sir William Temple, bart. : to which is prefixed, the life and character of the author, considerably enlarged.

--I. Life of the author. An essay on the original and nature of government. Observations upon the united provinces of the Netherlands. Letters containing an account of the most important transactions that passed in Christendom from 1665 to 1672.-II. Sequel of the author's letters, serving to supply the loss of the first part of his memoirs. A survey of the constitutions and interests of the empire, Sweden, Denmark, Spain, Holland, France, and Flanders in 1671. A letter to the Duke of Ormond, written in October 1673. Memoirs, pt. II--III.--III. [Essays] Poetry.--IV. Letters to the king, the Prince of Orange, &c. Index.

Memoirs of Lucien Bonaparte, (prince of Canino)

Mode of access: Internet.