O acento do latim ao português arcaico

Este estudo diz respeito ao acento do latim e do português arcaico. Interpretado o acento à luz da Fonologia Métrica, admitimos, seguindo Jacobs (1990, 1997), que o troqueu irregular caracteriza melhor o latim clássico do que o troqueu mórico. Depois de discutir o acento do latim clássico e dar especial atenção às enclíticas, que ampliam o domínio do acento e sobre as quais, com respeito a seu papel no acento, defendemos uma posição contrária à de análises mais recentes, citadas neste trabalho, passamos ao acento em latim vulgar e, após, ao acento em português arcaico. Nessa trajetória, observa-se a perda das proparoxítonas por síncope em latim vulgar e, subseqüentemente, a perda da vogal final por apócope em algumas palavras em português arcaico, resultando palavras terminadas em sílaba pesada. A simplicidade conduz a evolução do latim clássico ao vulgar, passando o sistema acentual do troqueu irregular ao troqueu silábico, mas, do latim vulgar ao português arcaico, há uma volta ao troqueu irregular, em virtude da ocorrência de palavras terminadas em sílaba pesada. Essas últimas linhas encerram a tese que esta análise sustenta.

A expressão imunoistoquímica das metaloproteinases-2 e -9 da matriz na rosácea inflamatória

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O estado brasileiro diante da globalização e da preferência pelo consumo imediato

O estado-nação é a unidade político-territorial específica do capitalismo. Na globalização a sua lógica é a mesma do capitalismo: competir. Mas para alcançar competitividade é preciso que neutralize a tendência à sobreapreciação cíclica e crônica da taxa de câmbio que existe nos países em desenvolvimento. O que depende de ter uma nação forte e de saber contornar a “preferência pelo consumo imediato”. Entretanto, tanto a ortodoxia liberal quanto o keynesianismo vulgar estimulam esse consumo. Só uma política novo desenvolvimentista poderá enfrentar esses problemas. Mas precisará evitar os riscos do desenvolvimentismo ingênuo

Síndrome de ovários policísticos: enfoque psicossocial

A síndrome dos ovários policísticos (SOP) é um distúrbio endócrino-ginecológico que se caracteriza, principalmente, por anovulação crónica e hiperandrogenismo, afetando entre 5 a 10% das mulheres em idade reprodutiva. As principais manifestações da SOP incluem os seguintes sintomas: irregularidade menstrual, hirsutismo, infertilidade, acne, alopecia androgenética, obesidade e acantose nigricans. Esses sintomas apresentam- se de forma bastante heterogênea, havendo diferenças marcantes na sua prevalência e intensidade entre diferentes grupos de mulheres que apresentam SOP. Apesar da condição biológica, a SOP não é apenas um problema físico, mas também psicossocial, interferindo e comprometendo a qualidade de vida das mulheres que a apresentam. A partir de uma revisão da literatura, este estudo discute os aspectos psicossociais de mulheres com SOP, destacando o impacto dos sintomas na qualidade de vida relacionada com a saúde. Considerando que cada mulher responde de forma singular aos sintomas que apresentam, destaca-se a importância de incorporar a perspectiva individual da mulher com SOP ao seu contexto social. Nesse sentido, são discutidos achados de pesquisas utilizando abordagens metodológicas quantitativas e qualitativas, numa tentativa de melhor compreender a experiência das mulheres diante da SOP. Os sintomas da SOP podem estar associados com a ocorrência de ansiedade, disfunções sexuais e sentimentos de inadequação ao papel feminino, como também podem desencadear sintomas depressivos e isolamento social, com comprometimento significativo da qualidade de vida. Os autores destacam a importância do atendimento multidisciplinar para as mulheres com SOP, considerando essa condição como importante problema psicossocial. A atenção aos aspectos psicossociais da SOP tem aumentado nos últimos anos, no entanto, a produção científica relacionada ainda é escassa

Álcool e sociabilidade: a farra das adolescentes

The experience as a school psychologist allowed me to notice that expressions like I was like trash in the gang s barbecue , and we chatted away, only the girls, and we all got drunk , are very common in conversations between Elementary and High School students, pointing out to a concerning incidence of alcohol consumption among female adolescents. However, studies about this theme haven t gone deep in the nowadays reality these girls are living in. This study aimed at comprehending the aspects of the relation between girls and alcohol, starting from the point that exaggerated consumption indicates introductory rituals for some groups, making social relations easier and becoming a sociability factor. To give this study some support, a questionnaire was applied to 1028 female teenagers, between 12 and 18 years old, students in private schools in Natal, capital of Rio Grande do Norte. The context chosen for the development of the study - private schools -, arose from the notion that the majority of the data collection carried out about alcohol and other psychotropic drugs aim at public school students. The instrument used was divided in two parts, one that treated about the first contact with alcohol (experimentation), and other that points to the current relation with alcoholic beverages, with 27 closed questions but nevertheless with available space for manifestation like if other; which?, applied collectively in classrooms. The data received a statistic treatment from SPSS and showed that the first contact with alcoholic beverage happens in domestic environment, having parents and friends as companions, very precociously, around 10 years of age, as curiosity. At this moment, Ice drink is the most consumed beverage. The main reason that leads them to drink is to pass the time in parties, and they don t drink alone (93% of students researched), what gives alcohol this recreational and socializing characteristic. They do consider alcohol a kind of drug, but are not afraid of getting addicted. People that drink usually show to be extroverted, they get happier (40,3%) and are not shy at all (29,4%), have attitudes of moral character, like to get involved with unknown boys (18,5%), get numb (9,9%), or get sad (1,9%). They label as vulgar the girls that drink, depending on the amount, and to be stimulated by the boys to drink. The study shows that systematic interventions of the school are necessary, once it is an institution that should care about education and personality traits of children and adolescents, as well as the important role of the psychologist in this context. Besides, it claims the society to get effectively involved with the public policies that already exist

Cuidados paliativos e ser-para-morte: reflexões sobre um atendimento psicológico

Death is a theme that fascinates, though at the same time, frightens and uneasy the human being, despite the finitude being present at our daily lives. In each historical time, death has been represented in a peculiar way, from familiar death (at Middle Ages), to interdicted death (at contemporary times). Through this path it‟s possible to recognize several attitudes and stages front of death and the process of dying as possibilities of coping and the understanding of these occurrences. In other hand, the palliative care proposal came as a humanized attention, front of the human finitude, recognizing death as a part of the vital cycle. The Brazilian reality, in this context, still faces a lot of political, economic and social barriers that makes difficult the consolidation of palliative care at the death process in the Brazilian Health Care policies. Currently, according to the Brazilian Palliative Care Association, Brazil presents an average of 40 services with this proposal. Such data portray our inexpressive condition in relation to these cares when considering the territorial extension and population of our country. Considering this scenario is relevant think about death and the process of dying at contemporary times, at a health context in which palliative care, when trying to humanize the process of dying, bring to light the issue of human finitude and the beingtowards- death, as thought by the philosopher Martin Heidegger. According to him, the human being (Dasein) is constituted as a being-towards-death, once death is its most own potentiality-for-bein and its last possibility to be lived. In view of the ideas presented, the proposed study appears as a qualitative research of existential-phenomenological inspiration and aims to understand the experience of being-toward-death from the psychological care to a person out of possibilities of cure living on palliative cares. The psychological care happened at the patient‟s home, understanding the clinical process of being-with-the-other from the written reports of the psychology/researcher, by the accompanying sessions, configured as an experience report. These reports are focused on the experiences lived by the patient, as well as apprehended by the psychologist at the intersubjectivity relation and its own experience with Dasein and, therefore, being-toward-death. The reports were hermeneutically interpreted, from the senses that emerged in this process, considering the notion of being-toward-death proposed by Heidegger. Furthermore, it was important to dialogue with other authors that approached the studied theme. It is perceived, through brief and meaningful reflections about the clinical treatments started, that the experience of illness with no possibilities of cure makes the Dasein revises feelings and experiences that were marked at the temporality and historicity of existence. It is a stage of life in which the cultural dimension and the common sense of finitude, often gains ground in the human condition, taken in its ordinary sense, unlike the way it has been thought from an ontological and existential perspective of death. Thus, there are singulars and revealing paths in the palliative care scenery as possible ways for authenticity of being-toward-death

Association between palmoplantar pustulosis and cigarette smoking in Brazil: a case-control study

BackgroundPalmoplantar pustulosis (PPP) discloses some differences compared to vulgar psoriasis (PV) in terms of age of onset, female predominance and low occurrence of psoriasis lesions elsewhere. Cigarette smoking has been associated to PPP in international studies; nevertheless, these studies were never performed among Brazilian.ObjectivesTo compare prevalence of smoking among PPP, PV and other dermatologic patients (NPD).MethodsCase-control study involving 25 PPP patients from a reference psoriasis centre. Two control groups were matched according to gender and age: 50 patients with PV and 50 NPD. Confounders were adjusted by conditional multiple logistic regression.ResultsAmong cases, 84.0% were female and PPP age of disease onset (41.4 years) was greater than PV (34.5 years). Prevalence of ever smoking was higher among cases (92.0%) than PV (52.0%) and NPD (30.0%). Adjusted odds ratio of PPP ever smoking compared to PV and NPD was 9.5 and 36.2, respectively. All smokers reported the onset of their habit before the development of PPP.ConclusionsThere was significant association between PPP and smoking. However, the impact of giving it up in the clinical course of the disease remains to be established.

Determinação espectrofotométrica de ácido glicólico com ácido cromotrópico assistida por forno de microondas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Uso de la cefalexina en infecciones piogenas de la piel: comparacion de dos esquemas terapeuticos

50 patients with pyogenic infections of the skin were divided into 2 groups and treated with cephalexin. Group A, 26 patients, received 500 mg/12 hours; Group B, 24 patients, 250 mg/6 hours. Clinical diagnosis was substantiated by bacteriologic study of cultures to identify the organism and determination of its susceptibility to the drug. Group A showed 91%, group B 95%; satisfactory results. No side-effects were noted. Either form of dosage was effective in the treatment of pyogenic infections of the skin.

Influência da concentração de antioxidante na estabilidade do ácido retinóico

Retinoic acid, which has been prescribed for some forms of acne since 1962, is subject to isomerization provoked by atmospheric oxygen and ambient light. Therefore it is very important to keep this material intact through the use of antioxidants. We tested two antioxidants: various concentrations of butylhydroxytoluene or BHT, widely used in cosmetic and dermatological preparations, and vitamin E, found in grape oil, an ingredient of skin lotion. Recently prepared lotions were subject to heat stress and the residual concentrations of retinoic acid determined at predetermined intervals through UV spectrophotometry. The shelf life of the various preparations were determined by the Arrhenius equation. The antioxidants helped conserve the retinoic acid, however, there was no synergism in antioxidant activity between the vitamin E in the grape seed oil and BHT.

Morphologic characterization and evaluation of the productivity of nine rootstocks of rose bush (rosa spp.)

In Brazil, garden and cut rose bushes are propagated through cuttings or grafting. The rootstocks used in most of the traditional areas of cultivation are not identified, being known just by the vulgar name. There is not any information in the literature on the morphologic characteristics, nor about the productivity of different cultivars on the rootstocks available in Brazil. The objective of this work was to characterize and determine productivity of nine rootstocks (Rosa multiflora 'Paulista'; R. multiflora 'Japones'; R. multiflora 'Iowa'; R. multiflora 'Kopmans'; R. indica 'Mayor'; R. indica x multiflora; R. sp. 'Natual Brier'; R. manetti and R. canina 'Inermis') grafted with 'Versilia' and 'Tineke' scions. Morphologic studies were undertaken to characterize branches of adult plants to determine shape and dimensions of the leaf; number of prickles/15 cm of stem; vigor of the stems; incidence of Diplocarpon rosae (blackspot) and coloration of the leaf. The productivity (number of commercial flowers/plant/month) was evaluated for 6 months (October, 2000 to March, 2001), in the city of Andradas, Minas Gerais State, located at 1251 meters above sea level. Since there was significant difference in just two months for both rootstocks, 'Tineke' and 'Versilia', no rootstocks could be considered inadequate. Nonetheless, in general, the rootstocks that showed a better performance with 'Tineke' were, R. multiflora 'Kopmans' and R. manetti and with 'Versilia', R. multiflora 'Kopmans' and Rosa sp. 'Natual Brier'.

Ensaios biológicos para avaliação de segurança de produtos cosméticos

Despite efforts to the contrary, some cosmetic products can cause undesirable side effects in the users. These may often be due to individual factors or inappropriate use of the product. Thus, biological assays to assess the safety of a new cosmetic must precede its being placed on the market. Historically, these tests have always been carried out in vivo, in animals, since such tests can be used to evaluate many of the potential risks, such as irritation, allergy or systemic effects; but, recently, some research centers have been adopting in vitro alternatives, in order to replace the animal tests. This review emphasizes the need to employ biological assays to test the safety of cosmetic products, and reviews the main in vivo and in vitro tests used, focusing on the need to develop and use alternatives to the in vivo assays of product safety, so as to offer the consumers the maximum safety with the least possible risk, while ensuring the best conditions of use of the product.

A randomized and controlled trial about the use of oral isotretinoin for photoaging

Topical retinoids are used to treat photoaging; oral isotretinoin is gold standard for acne; off label indications, including photoaging, have been reported with insufficient evidence of efficacy. This is a randomized controlled phase II trial with clinical and histological assessment to evaluate efficacy and safety of oral isotretinoin for photoaging. Study population was comprised of 32 menopausal or sterilized women, aged 40-55, divided in 2 groups: A (21) received 20mg isotretinoin, 3 times per week, nightly moisturizer, and daily sunscreen, for three months; B (11) just moisturizer/sunscreen. Main outcome measures were: overall clinical assessment; profilometry, corneometer and elasticity tests in periocular regions and left forearm; before/after biopsies from left forearm in patients of B and in 10 randomly selected of A. Microscopic blinded evaluation of epidermal thickness, dermal elastosis, new collagen, p53 epidermal expression was performed by quantitative digital image analysis. All data were submitted to statistical analysis. Clinical evaluation showed slight improvement; profilometry, corneometer and skin elasticity tests presented significant difference in pre/post values (P = 0.001 to 0.028), but no differences between A/B. Histological findings and p53 expression were comparable between groups before treatment (P > 0.1); microscopic analysis showed no differences between groups for most variables, after treatment. Slight but significant difference between A/B for p53 with major reduction post isotretinoin [0.66±0.31 vs. 0.94±0.34 respectively (P = 0.04) was observed. There were minor side effects and no significant laboratory test alterations. We concluded that no significant clinical, microscopic changes but p53 epidermal expression reduction were observed. The role of ultra-violet induced p53 mutation in skin carcinogenesis reinforces retinoids chemoprevention. Oral isotretinoin seemed safe but not effective to treat photoaging. Caution should be considered for women prone to pregnancy. Further controlled studies are necessary. © 2010 The International Society of Dermatology.

Keratinase production by new strain of Bacillus Amyloliquefaciens: Application of statistical experimental design for optimization of keratinase production

Feathers are rich in amino acids and can be employed as a dietary protein supplement for animal feed. Microbial degradation is an alternative technology for improving the nutritional value of feathers. Other potential applications of keratinase include use in the leather industry, detergents and medicine as well as the pharmaceutical for the treatment of acne, psoriasis and calluses. A new keratinolytic enzyme production bacterium was isolated from a poultry processing plant. To improve keratinase yield, statistically based experimental designs were applied to optimize three significant variables: temperature, substrate concentration (feathers) and agitation speed. Response surface methodology demonstrated an increase in keratinolytic activity at temperature, agitation speed and substrate concentration of 26.6°C, 150 rpm and 2%, respectively. Liquid chromatography revealed the release of amino acids in the Bacillus amyloliquefaciens culture broth, thereby demonstrating the potential of feather meal in the animal feed industry. © Global Science Publications.

Manifestações clínicas, bioquímicas, ultrassonográficas e metabólicas da síndrome dos ovários policísticos em adolescentes

PURPOSE: To evaluate the clinical, ultrasonographic, biochemical and metabolic alterations of adolescents with polycystic ovary syndrome (PCOS). METHODS: Retrospective observational study conducted on 44 adolescents aged 12 to 19 years, diagnosed with PCOS according to the Rotterdam Consensus. Metabolic changes were assessed according to the recommendations of the International Diabetes Federation, considering: waist circumference (WC) ≥90th percentile (10-15 years of age) or >80 cm (age >16 years), fasting glucose >100 mg/dL, triglycerides >150 mg/dL, HDL <40 mg/dL, and blood pressure ≥Hg 130/85 mm. RESULTS: Mean age was 16.7±2.2 years and age at menarche was 11.8±1.4 years. The menstrual irregularity most frequently observed was amenorrhea (72.7%) followed by oligomenorrhea (27.3%); hirsutism was observed in 86.4% and acne in 56.8%. Polycystic ovaries were observed by ultrasound only in 27.3%. Mean BMI was 30.3±6.6 kg/m2. According to BMI, 52.3% of adolescents were obese, 13.6% were overweight and 6.8% had a healthy weight. Increased waist circumference (63.6%, 28/44) and the reduction of HDL-C (34.1%, 15/44) were the metabolic changes most frequently observed. Increased triglycerides were observed in 27.3% (12/44) and increased blood pressure and impaired fasting glucose were found in 9.1% (4/44) and 4.5% (2/44) of cases, respectively. Acanthosis nigricans was observed in 52.3% and insulin resistance in 62.8% of the adolescents with PCOS. Metabolic syndrome was identified in six children (13.6%), all of them obese or overweight. CONCLUSION: In the adolescents with PCOS studied here, menstrual irregularity and hirsutism were the most common clinical manifestations, while the sonographic findings consistent with polycystic ovaries were less prevalent. Obesity associated with insulin resistance predisposes these adolescents to a higher frequency of metabolic disorders.