Enhanced AIMD based decentralized residential charging of EVs

Moving from combustion engine to electric vehicle (EV)-based transport is recognized as having a major role to play in reducing pollution, combating climate change and improving energy security. However, the introduction of EVs poses major challenges for power system operation. With increasing penetration of EVs, uncontrolled coincident charging may overload the grid and substantially increase peak power requirements. Developing smart grid technologies and appropriate charging strategies to support the role out of EVs is therefore a high priority. In this paper, we investigate the effectiveness of distributed additive increase and multiplicative decrease (AIMD) charging algorithms, as proposed by Stu¨dli et al. in 2012, at mitigating the impact of domestic charging of EVs on low-voltage distribution networks. In particular, a number of enhancements to the basic AIMD implementation are introduced to enable local power system infrastructure and voltage level constraints to be taken into account and to reduce peak power requirements. The enhanced AIMD EV charging strategies are evaluated using power system simulations for a typical low-voltage residential feeder network in Ireland. Results show that by using the proposed AIMD-based smart charging algorithms, 50% EV penetration can be accommodated, compared with only 10% with uncontrolled charging, without exceeding network infrastructure constraints.

Cathepsin S: therapeutic, diagnostic, and prognostic potential

Cathepsin S is a member of the cysteine cathepsin protease family. It is a lysosomal protease which can promote degradation of damaged or unwanted proteins in the endo-lysosomal pathway. Additionally, it has more specific roles such as MHC class II antigen presentation, where it is important in the degradation of the invariant chain. Unsurprisingly, mis-regulation has implicated cathepsin S in a variety of pathological processes including arthritis, cancer, and cardiovascular disease, where it becomes secreted and can act on extracellular substrates. In comparison to many other cysteine cathepsin family members, cathepsin S has uniquely restricted tissue expression and is more stable at a neutral pH, which supports its involvement and importance in localised disease microenvironments. In this review, we examine the known involvement of cathepsin S in disease, particularly with respect to recent work indicating its role in mediating pain, diabetes, and cystic fibrosis. We provide an overview of current literature with regards cathepsin S as a therapeutic target, as well as its role and potential as a predictive diagnostic and/or prognostic marker in these diseases.

Favorable effect on acute and chronic graft-versus-host disease with cyclophosphamide and in vivo anti-CD52 monoclonal antibodies for marrow transplantation from HLA-identical sibling donors for acquired aplastic anemia

Between August 1989 and November 2003, 33 patients at our center with acquired aplastic anemia underwent bone marrow transplantation (BMT) from HLA-identical sibling donors with cyclophosphamide and in vivo anti-CD52 monoclonal antibodies (MoAb) for conditioning. The median age at BMT was 17 years (range, 4-46 years). Before BMT, 58% were heavily transfused (>50 transfusions), and 42% had previously experienced treatment failure with antithymocyte globulin-based immunosuppressive therapy. Unmanipulated bone marrow was used as the source of stem cells in all patients except 1. Graft-versus-host disease (GVHD) prophylaxis was with cyclosporine alone in 19 (58%) patients; 14 received anti-CD52 MoAb in addition to cyclosporine. The conditioning regimen was well tolerated without significant acute toxicity. Graft failure was seen in 8 patients (primary, n = 4; secondary, n = 4). Of those whose grafts failed, 4 survived long-term (complete autologous recovery, n = 2; rescue with previously stored marrow, n = 1; second allograft, n = 1). The cumulative incidence of graft failure and grade II to IV acute and chronic GVHD was 24%, 14%, and 4%, respectively. None developed extensive chronic GVHD. With a median follow-up of 59 months, the 5-year survival was 81% (95% confidence interval, 68%-96%). No unexpected early or late infectious or noninfectious complications were observed. We conclude that the conditioning regimen containing cyclophosphamide and anti-CD52 MoAb is well tolerated and effective for acquired aplastic anemia with HLA-matched sibling donors. The favorable effect on the incidence and severity of GVHD is noteworthy in this study and warrants further investigation.

Boundary value problems for analytic functions in the class of Cauchy-type integrals with density in

We study the Riemann boundary value problem , for analytic functions in the class of analytic functions represented by the Cauchy-type integrals with density in the spaces with variable exponent. We consider both the case when the coefficient is piecewise continuous and it may be of a more general nature, admitting its oscillation. The explicit formulas for solutions in the variable exponent setting are given. The related singular integral equations in the same setting are also investigated. As an application there is derived some extension of the Szegö-Helson theorem to the case of variable exponents.

A evolução da contabilidade de gestão e a necessidade de informação

O objectivo deste artigo é apresentar o papel e o lugar da informação contabilística nos sistemas de informação das empresas e, em particular, a articulação entre a informação financeira e a não financeira nos sistemas de medida do desempenho. Por isso, procura-se interpretar claramente o contributo que a Contabilidade de Gestão pode conceder actualmente à gestão e ao controlo das organizações. A diversidade dos utilizadores da informação implica que sejam apresentadas as principais diferenças da informação proveniente da Contabilidade Financeira e da informação oriunda da Contabilidade de Gestão. Internamente, os gestores são confrontados continuamente com a necessidade de tomar decisões complexas, num ambiente empresarial em constante mutação. Dispor de informação oportuna e relevante sobre as consequências possíveis de uma dada afectação de recursos ou sobre as consequências passadas das afectações executadas é fundamental para a competitividade e para um bom desempenho, na medida em que o gestor escolhe a priori a acção que oferece melhor relação entre recursos consumidos e resultados obtidos. Os utilizadores externos necessitam de estar seguros de que as demonstrações financeiras são preparadas de acordo com os princípios contabilísticos geralmente aceites e que, por consequência, as comparações históricas e entre empresas são possíveis. Assim, para tomar decisões, estes utilizadores seleccionam a informação mais adequada às suas necessidades em função da sua relevância, da sua disponibilidade e da sua credibilidade.

O papel do poema «Correspondances» no Teatro de Vanguarda dos séculos XIX e XX

Ensaio produzido no quadro do Colóquio Internacional "Baudelaire (1821-867) e as Posteridades do Moderno", organizado por Jorge Fazenda Lourenço, Faculdade de Ciências Humanas, Universidade Católica Portuguesa, 2007.

Determination of airborne nanoparticles in elderly care centres

According to numerous studies, airborne nanoparticles have a potential to produce serious adverse human health effects when deposited into the respiratory tract. The most important parts of the lung are the alveolar regions with their enormous surface areas and potential to transfer nanoparticles into the blood stream. These effects may be potentiated in case of the elderly, since this population is more susceptible to air pollutants in general and more to nanoparticles than larger particles. The main goal of this investigation was to determine the exposure of institutionalized elders to nanoparticles using Nanoparticle Surface Area Monitor (NSAM) equipment to calculate the deposited surface area (DSA) of nanoparticles into elderly lungs. In total, 193 institutionalized individuals over 65 yr of age were examined in four elderly care centers (ECC). The occupancy daily pattern was achieved by applying a questionnaire, and it was concluded that these subjects spent most of their time indoors, including the bedroom and living room, the indoor microenvironments with higher prevalence of elderly occupancy. The deposited surface area ranged from 10 to 46 mu m(2)/cm(3). The living rooms presented significantly higher levels compared with bedrooms. Comparing PM10 concentrations with nanoparticles deposited surface area in elderly lungs, it is conceivable that living rooms presented the highest concentration of PM10 and were similar to the highest average DSA. The temporal distribution of DSA was also assessed. While data showed a quantitative fluctuation in values in bedrooms, high peaks were detected in living rooms.

New gene functions in megakaryopoiesis and platelet formation.

Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is only limited understanding of the molecular processes controlling both traits. Here we carried out a high-powered meta-analysis of genome-wide association studies (GWAS) in up to 66,867 individuals of European ancestry, followed by extensive biological and functional assessment. We identified 68 genomic loci reliably associated with platelet count and volume mapping to established and putative novel regulators of megakaryopoiesis and platelet formation. These genes show megakaryocyte-specific gene expression patterns and extensive network connectivity. Using gene silencing in Danio rerio and Drosophila melanogaster, we identified 11 of the genes as novel regulators of blood cell formation. Taken together, our findings advance understanding of novel gene functions controlling fate-determining events during megakaryopoiesis and platelet formation, providing a new example of successful translation of GWAS to function.

Informe preliminar del crucero de invierno 1965 (Mácora - Morro Sama)

Describe información acerca del desove de la anchoveta mediante la recolección de planctoncon red hansen. Así mimso, presenta investigaciones sobre la presencia de cardúmenes de peces por medio del eco-sonda y sonar, observaciones de aves y mamiferos marinos.

L'Écho de Paris

1886/07/28 (Numéro 867).

Recueil de copies et de pièces originales, manuscrites et imprimées, sur la Marine (listes d'officiers, revues, états, procès de discipline, ports de Marseille, Toulon, Dunkerque, Brest, Rochefort, etc., les Galères et les Colonies) de 1663 à 1754. II Années 1663-1699. — Lettres orig. notamment du chevalier de Valbelle, Messine 1676 (p. 191), de Me Agnès de Bonvoison, Toulon 1687 (p. 576 et 588), de M. de la Planche, Boulogne 1687 (p. 582), de M. d'Argenson, Paris 1699 (p. 1002 et 1014).

Contient : Réception d'ambassadeurs (1663-1686) ; Pièces sur l'Acadie et le Canada ; « Lettera scritta da Venetia da un partiale del popolo di Messina all' Eccellentiss. Senato de quella città ». Impr. S. l. n. d., in-8° de 14 pages ; « Arrest de la Cour du Parlement contre la nommée Jeanne Moyon, veuve Jean Lesur, et autres, accusées de prostitution publique. » Impr. Paris, P.-G. Simon, 1750, in-4° de 4 pages ; Extrait de la relation envoyée par M. de Terron du combat naval du 8 janvier 1776 ; Inscriptions de l'Arsenal de Brest, par Victorin Santeul et P. Corneille ; « Discorso sopra le due comete apparse l'anno corrente 1682 gl'ultimi giorni d'agosto... dedicate all' ill. et eccell. sig. Nicolo Doria, senatore della Republica de Genova... » Impr. Gênes, Antonio Casamara, s. d., in-4° de 8 pages ; « Coppie d'une lettre qu'un François écrit à un de ses amis, contenant ce qui s'est passé à Gênes pour célébrer la naissance de Mgr le duc de Bourgogne. » Impr. Marseille, P. Mesnier, 1682, in-4° de 12 pages ; Liste des vaisseaux danois armés à Copenhague en 1683 ; « Liste des officiers qui sont dans les forts Cataracoüy et Niagara. » ; Pièces sur Cayenne ; Pêche de la baleine ; Envoi de denrées en Irlande

Inventaire des lettres d'anoblissement, de légitimation et de naturalité, enregistrées à la chambre des comptes de 1349 à 1655.

Contient : a Acte, en latin, du roi CHARLES VIII. Le roi y anoblit Éloi Gigaud et sa postérité. Éloi Gigaud est dit demeurer « in parrochia de Mehers, prope Castriam, in provincia Bituriae ». Plessis lez Tours, mai 1489 ; b Note concernant la famille Nicolay, de 1440 à 1588, où l'on examine à quelle date la qualité de noble à été donnée à Jean Nicolay, père du premier Nicolay qui fut « premier president aux comptes à Paris ». On a joint à cette note la copie de trois actes, en latin, des années 1452, 1469, 1522. Jean Nicolay figure dans les deux premiers, et son fils, le premier président, dans le troisième ; c Acte par lequel le roi LOUIS XIV déclare légitimés ses enfants naturels Louis-Auguste, duc du Maine, Louis-César, comte du Vexin, Louise-Françoise de Nantes. St-Germain-en-Laye, décembre 1673 ; d Le « lieu de Mouchy le Vieil », donné à « Jean, bastard de Tyen, bailly de Senlis, au mois de juin 1422 » ; e « Me Jean Bruslard,... ordonné avocat... du roy en la prevosté de Chastillon sur Marne, par lettres du roy du 28 fevrier 1423 » ; f La famille de Jeanne d'Arc. 1429 et 1473 ; g Un mandement du roi Louis XI « au seigneur de La Roche-Guyon », pour « laisser passer 60 tonneaux de vin », envoyés par ledit roi au roi d'Angleterre, Henri VI. Paris, 16 nov. 1470