Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study

The current study investigates the feasibility of using a biodegradable polymeric stent in common bile duct (CBD) repair and reconstruction. Here, poly(l-lactide-co-glycolide) (PLGA, molar ratio LA/GA = 80/20) was processed into a circular tube- and dumbbell-shaped specimens to determine the in vitro degradation behavior in bile. The morphology, weight loss, and molecular weight changes were then investigated in conjunction with evaluations of the mechanical properties of the specimen. Circular tube-shaped PLGA stents with X-ray opacity were subsequently used in common bile duct exploration (CBDE) and primary suturing in canine models. Next, X-ray images of CBD stents in vivo were compared and levels of serum liver enzymes and a histological analysis were conducted after stent transplantation. The results showed that the PLGA stents exhibited the required biomedical properties and spontaneously disappeared from CBDs in 4-5 weeks. The degradation period and function match the requirements in repair and reconstruction of CBDs to support the duct, guide bile drainage, and reduce T-tube-related complications.

SeGPX activity of three organoselenium-containing cyclodextrins and their scavenging effects on HO center dot

Three organoselenium-containing derivatives of beta-cyclodextrins (beta-CD), mono-6-benzylseleno-6-deoxy-beta-cyclodextrin (compound 1), 6,6'-trimethylenediseleno bridged beta-cyclodextrin dimer(compound 2) and 6,6'- (o-phenylene)diseleno bridged beta-cyclodextrin dimer (compound 3) functioned as mimics of selenium-containing glutathione peroxidase(SeGPX). Acting on H2O2 and GSH, the SeGPX activities of these compounds were 0.83-, 0.26-, and 1. 23-fold of that of Ebselen (0.99 U/mu mol), respectively. The relationship between the structure and the function of these compounds was studied. The results suggested that the hydrophobicity and rigidity of phenyl group is the main reason that accounted for the higher activity of compounds 3 and 1. Phenyl group not only provided the hydrophobic circumstance which is necessary for the catalytic function of selenium, but also make it possible that the cyclodextrin unit of compounds 1 and 3 combines the substrate with a more effective direction. Fluorometric techniques were utilized to determine the yields of the hydroxyl radical produced by Fenton reactions through the formation of hydroxy benzoic acids from benzoate. Compared with Ebselen which showed a significant inhibition effect on the formation of HO., these organoselenium-containing cyclodextrins showed a little scavenging effect on the formation of HO. throughout the whole process.

三种含硒环糊精的SeGPX活力及对HO·的清除作用

报道了 3种硒代 β-环糊精作为 Se GPX模拟物的活力 ,并初步探讨了含硒环糊精的结构与活力的关系 .利用 Fenton反应产生的羟基自由基与苯甲酸钠反应生成的具有荧光的羟基苯甲酸间接测定羟基自由基的含量 .结果表明 ,3种含硒环糊精对 HO·的生成均无明显的抑制作用.

Study on structure-property relationships between color reagents and sensitivity of color reactions with yttrium by topological indices

In this paper, three topological indices, Am-1, Am-2, and Am-3, multivariate analysis in structure-property studies. The topological indices of twenty asymmetrical phosphosphono bisazo derivatives of chromotropic acid have been calculated. The structure-property relationships between color reagents and molar absorptivity of color reactions with yttrium have been studied by A(m) indices and structure selective factors. Good results have been obtained by using correlation equation to predict the molar absorptivity of new color reagents.

拓扑指数法研究稀土显色剂结构与钇显色反应灵敏度的关系

本文计算了二十种不对称变色酸双偶氮膦酸型显色剂的A_m指数,并将其与钇进行显色反应的灵敏度进行相关性研究,讨论了显色剂结构对显色反应灵敏度的影响,预报了几种显色剂与钇显色反应的灵敏度,取得较为满意的结果.

7-碘-8-羟基喹啉-5-磺酸-溴化十六烷基三甲铵荧光光度法测定痕量镥

本文研究了镥-Ferron-表面活性剂三元荧光体系的荧光特性,各种表面活性剂中以溴化十六烷基三甲铵的增敏效果最佳,与相应的二元体系相比较,灵敏度提高近10倍。镥的测定下限可达8.8ng/ml。本法与P_(507)萃取色谱分离法相结合可用于天然混合稀土氧化物中痕量镥的测定,结果较满意。

Identification of a C-type lectin from the bay scallop Argopecten irradians

C-type lectins are Ca2+ dependent carbohydrate-recognition proteins that play crucial roles in the invertebrate innate immunity, such as nonself recognition, activation of proPO system, antibacterial activity, promotion of phagocytosis and nodule formation. In this study, a novel C-type lectin of bay scallops Argopecten irradians (Ai Lec) was identified using expressed sequence tag (EST) and RACE techniques. The Ai Lec cDNA encoded a polypeptide of 171 amino acids with a putative signal peptide of 21 amino acid residues and a mature protein of 150 amino acids. The deduced amino acid sequence of Ai Lec was highly similar to those of the C-type lectins from other animals and contained a typical carbohydrate-recognition domain (CRD) of 131 residues, which has four conserved disulfide-bonded cysteine residues that define the CRD and two additional cysteine residues at the amino terminus. The expression of Ai Lec transcript was dominantly detected in the hepatopancreas and slightly detected in the haemocytes of normal scallops. 6 h after Vibrio anguillarum-challenge and 8 h after Micrococcus luteus-challenge, the temporal expression of Ai Lec mRNA in hemocytes was increased by 4.4- and 3.6-folds, respectively. The results suggested that Ai Lec was a constitutive and inducible acute-phase protein and might be involved in immune response to Gram-negative and Gram-positive microbial infection in bay scallop A. irradians.

Simple, mild and convenient synthesis of two novel N-dichloroacetyl oxazolidines and their biological activities

Two N-dichloroacetyl oxazolidines were synthesized with a simple, mild and convenient method. All the compounds were characterized by IR, (HNMR)-H-1 and elemental analysis. The preliminary biological test showed that the compounds protected maize against injury by some herbicides to some extent.

鬼灯檠属的系统发育、分类和地理分布

本文对鬼灯檠属Rodgersia Gray的染色体数、花粉体积和纹饰、萼片数目、萼片脉序和脉型、萼片腹面毛被、花梗和花序轴毛被、叶的类型等关键性状进行了分析,确定了其进化顺序;依据性状的系统发生,绘制了鬼灯檠属的瓦格勒尔系统树;确认本属有5种和3变种,其中以R.podophylla为最原始, R.nepalensis为最进化,而R.aesculifolia,R.sambucifolia和R.pinnata则居于两者之间。本属分两组Sect.Rodgersia,仅含R.podophylla;Sect.Sambuclfolia J.T.Pan,含R.aesculifolia,R.sambucifolia,R.pinnata,R.nepalensis。依据种的主要分布区,划本属植物为4个分布类型,即:日本-朝鲜间断分布,秦岭-大巴山分布,横断山分布和东喜马拉雅分布。笔者认为, 本属的起源地在日本一朝鲜一带, 横断山地区是其现代分布中心和分化中心本属的散布路线是自日本一朝鲜, 经秦岭一大巴山, 通过横断山地区而进入东喜马拉雅本属的起源时间, 当在晚第三纪以前晚白要世至早第三纪。此外, 还报道了鬼灯集属植物的花粉形态。

分布式多机器人装配系统任务合作规划算法研究

:综述了多机器人系统任务规划的研究 ,介绍了基于 Agent的分布协作式多机器人装配系统 ,给出了分布式多机器人系统任务协商规划算法 ,采用了改进的合同网协议方法。针对多机器人任务规划算法的软件实现 ,采用了先进的分布式对象技术 ,介绍了算法的具体实现方法

Zionism and the Jewish People, 1918-1960: From Minority to Hegemony

Rubinstein, W. (2001). Zionism and the Jewish People, 1918-1960: From Minority to Hegemony. The Jewish Journal of Sociology. 43(1-2), pp.5-36. RAE2008

Asesoría de diseño en producción, mejoramiento y desarrollo de nuevos productos para los municipios La Unión, Genóva, San Pablo, Consacá, Sapuyes, Ancuya, Sandoná, La Florida y Linares en los oficios de sombrerería y tejeduría en Iraca (paja toquilla).

132 hojas : ilustraciones a color.

Practice links [Issue 40, December 2010]

Practice Links is a free e-publication for practitioners working in Irish social services, voluntary and nongovernmental sectors. Practice Links was created to enable practitioners to keep up-to-date with new publications, electronic resources and conference opportunities. Issue 40 contains details of various international conferences and recently published research and resources designed to further professional development for social workers.