Sea Level Pressure Variability Over the Southern Indian Ocean Inferred from a Glaciochemical Record in Princess Elizabeth Land, East Antarctica

A 250-year, high-resolution, multivariate ice core record from LGB65 (70degrees50'07"S, 77degrees04'29"E; 1850 m asl), Princess Elizabeth Land (PEL), is used to investigate sea level pressure (SLP) variability over the southern Indian Ocean (SIO). Empirical orthogonal function (EOF) analysis reveals that the first EOF (EOF1) of the glaciochemical record from LGB65 represents most of the variability in sea salt throughout the 250-year record. EOF1 is negatively correlated (95% confidence level and higher) to instrumental mean sea level pressure (MSLP) at Kerguelen and New Amsterdam islands, SIO. On the basis of comparison with NCEP/NCAR reanalysis, strong correlations were found between sea-salt variations and a quasi-stationary low that lies to the north of Prydz Bay, SIO. Comparison with a 250-year-long summer transpolar index (STPI) inferred from sub-Antarctic tree ring records reveals strong coherency. Decadal-scale SLP variability over SIO suggests shifting of the polar vortex. Prominent decadal-scale deepening of the southern Indian Ocean low (SIOL) exists circa 1790, 1810, 1835, 1860, 1880, 1900, and 1940 A. D., continuously after the 1970s, and prominent weakening circa 1750, 1795, 1825, 1850, 1870, 1890, 1910, and 1955 A. D. The LGB65 sea-salt record is characterized by significant decadal-scale variability with a strong similar to21-year periodic structure (99.9% confidence level). The relationship between LGB65 sea salt and solar irradiance changes shows that this periodicity is possibly the solar Hale cycle ( 22 years).

Shakespeare's Richard II and Henry V and Political Rebellions in the Reign of Queen Elizabeth I

The purpose of this thesis will be to examine how two acts of rebellion against Queen Elizabeth I influenced Shakespeare's writing of Richard II and Henry V, as well as the performance and publication of these plays. The treasonous plots and execution of Mary, Queen of Scots in the 1580s, as well as the failed Essex Rebellion of 1601, resulted in a sensitivity towards any writings that seemed to support a coup d'état. Shakespeare, being a well-informed and fairly well-connected playwright, wrote passages in the afore mentioned plays that clearly reflect the political turmoil of the times. Thus, his plays were censored both on stage and in print until after the death of Elizabeth in 1603.

The role of ATM in the cell cycle control of V(D)J recombination

Lymphocyte development requires the assembly of diversified antigen receptor complexes generated by the genetically programmed V(D)J recombination event. Because germline DNA is cut, introducing potentially dangerous double-stranded breaks (DSBs) and rearranged prior to repair, its activity is limited to the non-cycling stages of the cell cycle, G0/G1. The potential involvement of a key mediator, Ataxia Telangiectasia Mutated or ATM, in the DNA damage response (DDR) and cell cycle checkpoints has been implicated in recombination, but its role is not fully understood. Thymic lymphomas from ATM deficient mice contain clonal chromosomal translocations involving the T-cell antigen receptor (TCR). A previous report found ATM and its downstream target p53 associated with V(D)J intermediates, suggesting the DDR senses recombination. In this study, we sought to understand the role of ATM in V(D)J recombination. Developing thymocytes from ATM deficient mice were analyzed according to the cell cycle to detect V(D)J intermediates. Examination of all TCR loci in the non-cycling (G0/G1) and cycling (S/G2/M) fractions revealed the persistence of intermediates in ATM deficient thymocytes, contrary to the wild-type in which intermediates are found only during G0/G1. Further analysis found no defect in end-joining of intermediates, nor were they detected in developed T-cells. Based upon the presence of persisting intermediates, the recombination initiating nuclease Rag-2 was examined; strict regulation limits it to G 0/G1. Rag-2 regulation was not affected by an ATM deficiency as Rag-2 expression remained contained within G0/G 1, indicating recombination is not continuous. To determine if an ATM deficiency affects recognition of V(D)J breaks, sites of recombination identified by a TCR locus or Rag expression were analyzed according to co-localization with a DDR factor phosphorylated immediately after DNA damage, phosphorylated H2AX (γH2AX). No differences in co-localization were found between the wild-type and ATM deficiency, demonstrating ATM deficient lymphocytes retain the ability to recognize DSBs. Together, these results suggest ATM is necessary in the cell cycle regulation of recombination but not essential for the identification of V(D)J breaks. ATM ensures the containment of intermediates within G0/G1 and maintains genomic stability of developing lymphocytes, emphasizing its fundamental role in preventing tumorigenesis.^

O capital dá a palavra:um estudo do discurso da responsabilidade social na revista Brasil Sustentável

O tema desta pesquisa é a formação do discurso da responsabilidade social empresarial por meio da revista especializada publicada pelo Conselho Empresarial Brasileiro para o Desenvolvimento Sustentável (CEBDS), a Brasil Sustentável. A análise de um veículo de comunicação especializado no tema da responsabilidade social tem o objetivo de definir características que concorram para a elaboração de um discurso que ganha divulgação e relevância na sociedade, e assim contribuir para uma melhor compreensão desse fenômeno. Levando-se em conta um cenário de transformações do capitalismo no pós-moderno, o trabalho vai investigar como ocorre o processo de ressignificação do papel da empresa privada para uma nova inserção na agenda política de debates. O trabalho será desenvolvido com a base teórica das formulações da análise do discurso (AD), utilizando-se seus conceitos e ferramentas para um estudo do discurso da responsabilidade social empresarial inscrito num quadro social e histórico ampliado.(AU)

O capital dá a palavra:um estudo do discurso da responsabilidade social na revista Brasil Sustentável

O tema desta pesquisa é a formação do discurso da responsabilidade social empresarial por meio da revista especializada publicada pelo Conselho Empresarial Brasileiro para o Desenvolvimento Sustentável (CEBDS), a Brasil Sustentável. A análise de um veículo de comunicação especializado no tema da responsabilidade social tem o objetivo de definir características que concorram para a elaboração de um discurso que ganha divulgação e relevância na sociedade, e assim contribuir para uma melhor compreensão desse fenômeno. Levando-se em conta um cenário de transformações do capitalismo no pós-moderno, o trabalho vai investigar como ocorre o processo de ressignificação do papel da empresa privada para uma nova inserção na agenda política de debates. O trabalho será desenvolvido com a base teórica das formulações da análise do discurso (AD), utilizando-se seus conceitos e ferramentas para um estudo do discurso da responsabilidade social empresarial inscrito num quadro social e histórico ampliado.(AU)

Bidirectional, experience-dependent regulation of N-methyl-d-aspartate receptor subunit composition in the rat visual cortex during postnatal development

In the visual cortex, as elsewhere, N-methyl-d-aspartate receptors (NMDARs) play a critical role in triggering long-term, experience-dependent synaptic plasticity. Modifications of NMDAR subunit composition alter receptor function, and could have a large impact on the properties of synaptic plasticity. We have used immunoblot analysis to investigate the effects of age and visual experience on the expression of different NMDAR subunits in synaptoneurosomes prepared from rat visual cortices. NMDARs at birth are comprised of NR2B and NR1 subunits, and, over the first 5 postnatal weeks, there is a progressive inclusion of the NR2A subunit. Dark rearing from birth attenuates the developmental increase in NR2A. Levels of NR2A increase rapidly (in <2 hr) when dark-reared animals are exposed to light, and decrease gradually over the course of 3 to 4 days when animals are deprived of light. These data reveal that NMDAR subunit composition in the visual cortex is remarkably dynamic and bidirectionally regulated by sensory experience. We propose that NMDAR subunit regulation is a mechanism for experience-dependent modulation of synaptic plasticity in the visual cortex, and serves to maintain synaptic strength within an optimal dynamic range.

Increased CNS levels of apolipoprotein D in schizophrenic and bipolar subjects: Implications for the pathophysiology of psychiatric disorders

Chronic administration of the atypical antipsychotic drug, clozapine, to rodents has been shown to increase the concentration of apolipoprotein D (apoD) in several area of the brain, suggesting that apoD could be involved in the therapeutic effects of antipsychotic drugs and/or the pathology of psychotic illnesses. Here, we measured a significant decrease in the concentration of apoD in serum samples from schizophrenic patients. In contrast, apoD levels were significantly increased (92–287%) in dorsolateral prefrontal cortex (Brodmann's area 9) of schizophrenic and bipolar subjects. Elevated levels of apoD expression were also observed in the caudate of schizophrenic and bipolar subjects (68–89%). No differences in apoD immunoreactivity were detected in occipital cortex (Brodmann's area 18) in either group, or in the hippocampus, substantia nigra, or cerebellum of the schizophrenic group. The low serum concentrations of apoD observed in these patients supports recent hypotheses involving systemic insufficiencies in lipid metabolism/signaling in schizophrenia. Elevation of apoD expression selectively within central nervous system regions implicated in the pathology of these neuropsychiatric disorders suggests a focal compensatory response that neuroleptic drug regimens may augment.

Letters from Elizabeth Degen to William Tudor,

Four letters on topics such as Tudor’s travel plans, news of friends, and the Degen children.

Letters from Elizabeth Degen to William Tudor,

Three letters recounting news of friends and Degen’s social activities in Ligorno.

Sharḥ-i Qaṣīdah-ʼi Burdah : manuscript, 1661

Written in one column, 19 lines per page, in black rubricated in red. Portions of text underlined or punctuated in red

The Zurich letters (second series) comprising the correspondence of several English bishops and others with some of the Helvetian reformers, during the reign of Queen Elizabeth.

Half-title: The Zurich letters. (Second series) A.D. 1558-1602.

Yad vÌ£a-shem : o Sokhen ha-melek : sipur yesodato be-kÌ£orot divre ha-yamim vÌ£eha-Yehudim bi-shenat 1669 = Iï¸ A︡d vosheÄ­m /

Mode of access: Internet.

Romantic biography of the age of Elizabeth; or, Sketches of life from the bye-ways of history.

v. 1. Introduction. Margaret of Valois, Queen of Henry IV. Robert Dudley, Earl of Leicester. Castelnau, Ambassador from France. La Mothe Fenelon. La Mothe Fenelon and Castelnau. Thomas Howard, fourth duke of Norfolk. Hugh, Earl of Tyrone, and notices of Walter, 1st Earl of Essex. Dr. Dee.--v. 2. Calvin and the church of Geneva. William Whittingham and the Puritans. Archbishop Whitgift and Dr. Cartwright. John Darrel, the exorcist. Loyola and the order of the Jesuits. Robert Parsons, Edmund Campian, and the Jesuits in England. Pope Sixtus V. Charles de Valois, Duc d'Angoulême. Henry de la Tour d'Auvergne, Viscount Turenne and Duke de Bouillon.

Louis XV et Élisabeth de Russie; étude sur les rélations de la France et de la Russie au dix-huitième siècle, d'après les archives du Ministère des affaires étrangères,

Mode of access: Internet.