Die Lehre von der Mora. : Dargestellt nach Grundsätzen des römischen Rechts /

"Vorrede" contains bibliography.

Markgraf Gero; ein beitrag zum verständniss der deutschen reichsgeschichte unter den Ottonen. Nebst einer gaugeographie von Thüringen und der Ostmark.

On fly-leaf:"Carl Friedr. von Posern- Vitett, 1853" in MS.

Litteratur des gesammten sowohl natürlichen als positiven Völkerrechts microform : nebst vorangeschickter Abhandlung von dem Umfange des gesammten sowohl natürlichen als positiven Völkerrechts, und Ankündigung eines zu bearbeitenden vollständigen Systems desselben /

Vol. 3 has added t.p.: Literatur des gesammten, sowohl natürlichen als positiven Völkerrechts.

Neue Literatur des Völkerrechts seit dem Jahre 1784; als Ergänzung und fortsetzung des Werks des Gesandten von Ompteda.

Added t.p.: Literatur des gesammten, sowohl natürlichen als positiven Völkerrechts, von Died. Hein. Lud. Freiherrn v. Ompteda, ergänzt und fortgesetzt von Carl Albert von Kamptz. 3. Th.

Rudolf von Jhering, 1852-1868 : briefe und erinnerungen /

Mode of access: Internet.

Werke und tage /

Mode of access: Internet.

Briefe von und an Friedrich von Gentz : auf Veranlassung und mit Unterstützung der Wedekind-Stiftung zu Göttingen /

Includes indexes.

Die entwicklung der clavier-musik von Bach bis Schumann.

Mode of access: Internet.

Preussens Geschichte in Wort und Bild : illustrirte Geschichte von Brandenburg und Preussen : mit besonderer Rücksicht auf die Entwicklung von Kultur, Sitte und Geistesleben in Deutschland /

Map by the engraver J.D. Schleuer in pocket of v. 4.

Johannes von Müllers sämmtliche Werke /

Publisher's advertisements: [1] or more leaves at end of some volumes.

EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer : analysis of data from the phase 3 FLEX study

Background: Findings from the phase 3 First-Line ErbituX in lung cancer (FLEX) study showed that the addition of cetuximab to first-line chemotherapy significantly improved overall survival compared with chemotherapy alone (hazard ratio [HR] 0·871, 95% CI 0·762-0·996; p=0·044) in patients with advanced non-small-cell lung cancer (NSCLC). To define patients benefiting most from cetuximab, we studied the association of tumour EGFR expression level with clinical outcome in FLEX study patients. Methods: We used prospectively collected tumour EGFR expression data to generate an immunohistochemistry score for FLEX study patients on a continuous scale of 0-300. We used response data to select an outcome-based discriminatory threshold immunohistochemistry score for EGFR expression of 200. Treatment outcome was analysed in patients with low (immunohistochemistry score <200) and high (≥200) tumour EGFR expression. The primary endpoint in the FLEX study was overall survival. We analysed patients from the FLEX intention-to-treat (ITT) population. The FLEX study is registered with ClinicalTrials.gov, number NCT00148798. Findings: Tumour EGFR immunohistochemistry data were available for 1121 of 1125 (99·6%) patients from the FLEX study ITT population. High EGFR expression was scored for 345 (31%) evaluable patients and low for 776 (69%) patients. For patients in the high EGFR expression group, overall survival was longer in the chemotherapy plus cetuximab group than in the chemotherapy alone group (median 12·0 months [95% CI 10·2-15·2] vs 9·6 months [7·6-10·6]; HR 0·73, 0·58-0·93; p=0·011), with no meaningful increase in side-effects. We recorded no corresponding survival benefit for patients in the low EGFR expression group (median 9·8 months [8·9-12·2] vs 10·3 months [9·2-11·5]; HR 0·99, 0·84-1·16; p=0·88). A treatment interaction test assessing the difference in the HRs for overall survival between the EGFR expression groups suggested a predictive value for EGFR expression (p=0·044). Interpretation: High EGFR expression is a tumour biomarker that can predict survival benefit from the addition of cetuximab to first-line chemotherapy in patients with advanced NSCLC. Assessment of EGFR expression could offer a personalised treatment approach in this setting. Funding: Merck KGaA. © 2012 Elsevier Ltd.

Memoirs : Heida Hermanns Holde /

The author's mother Alice Goldschmidt was a gifted piano player, who studied with Carl Maria Breithaupt and became his most talented student. Childhood recollections. Early musical awakening. Outbreak of World War One. Recollections of air raids and scarceness of food. Inflation and political instability in post-war Germany. Piano lessons by her mother from an early age. Heida made her debut at age fourteen with the Wiesbaden Symphony under the conductor Carl Schuricht, who became a close mentor and friend. Close relationship to her mother, who had a great influence on her professional career. Heida had a number of outstanding teachers, among them Artur Schnabel, Karl Leimer and Egon Petri. Heida was accepted as a student of Petri at the "Hochschule fuer Musik" in Berlin, where she studied between 1922-1925. Salon at her aunt's house with guests such as the playwright Georg Kaiser and Siegfried Wagner. Her sister Elsie received her Ph.D. in economics and moved to Berlin as well. Heida graduated from the "Hochschule" in 1925. Soon after she won an international piano competition in Berlin. Engagements with various conductors such as Max Fiedler and Otto Klemperer. Private lessons with Arthur Schnabel and Carl Friedberg, the co-founder of Juilliard. Due to occasional experiences of antisemitism during her music career Heida decided to change her name from Goldschmidt to Hermanns. Position at the "Hoch Conservatory" in Frankfurt. Encounter with the music critic Artur Holde, Heida's future-husband. Engagement and wedding in 1932. Move to Berlin.

A blackboard architecture for a hybrid CBR system for scientific software

This paper describes the use of a blackboard architecture for building a hybrid case based reasoning (CBR) system. The Smartfire fire field modelling package has been built using this architecture and includes a CBR component. It allows the integration into the system of qualitative spatial reasoning knowledge from domain experts. The system can be used for the automatic set-up of fire field models. This enables fire safety practitioners who are not expert in modelling techniques to use a fire modelling tool. The paper discusses the integrating powers of the architecture, which is based on a common knowledge representation comprising a metric diagram and place vocabulary and mechanisms for adaptation and conflict resolution built on the Blackboard.