O papel das tecnologias digitais em disciplinas de álgebra linear a distância: possibilidades, limites e desafios

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

As temporalidades que caracterizam a agricultura familiar do município de Marmeleiro (PR)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

As cidades médias e suas múltiplas particularidades: produção e consumo do espaço urbano em Marília - SP e Mossoró - RN

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Finzioni teoriche: letteratura e mistica, storia e psicoanalisi in Michel de Certeau

Il presente studio discute il concetto di “finzione teorica” di Michel de Certeau quale momento di raccordo tra letteratura e storiografia. La concezione dell’altro e dell’assente propria della mistica e il modello di temporalità della psicoanalisi sono riconosciute come matrici del suo pensiero.

Body Mass Index and Cancer Risk: The Evidence for Causal Association

Increased body mass index (BMI), as an approximation of body adiposity, is a risk factor for developing several adult malignancies. To quantify these risks, we reported a comprehensive systematic review (Lancet 2008; 371: 569-78) of prospective observational studies determining associations between BMI and risk of incident cancer for 20 cancer types. We demonstrated that associations are: (i) sex-specific; (ii) exist for a wider range of malignancies than previously thought; and (iii) are broadly consistent across geographic populations. In the present paper, we tested these data against the Bradford-Hill criteria of causal association, and argue that the available data support strength of association, consistency, specificity, temporality, biological gradient, plausibility, coherence and probably analogy. However, the experimental evidence supporting reversibility is currently lacking, though indirect evidence from longitudinal data in cohort studies and long-term follow-up post-bariatric surgery is emerging. We additionally assessed these data against appropriate adjustment for available confounding factors; measurement error and study design; and residual confounding; and found lack of alternative explanations. We conclude that there is considerable evidence to support a causal association between BMI and risk for many cancer types, but in order to establish the role of weight control in cancer prevention, there is a need to develop trial frameworks in which to better test reversibility.

Mobile Temporalities: Place, Ruination and the Dialectics of Time

In this chapter I explore the ambiguous, contradictory and often transient ways the past enters into our lives. I shed light on the interplay of mobility and temporality in the lifeworlds of two Somalis who left Mogadishu with the outbreak of the war in the 1990s. Looking into the ways they actively make sense of this crucial ‘memory-place’ (Ricoeur 2004), a place that that has been turned into a landscape of ruins and rubble, alternative understandings of memory and temporality will emerge. Instead of producing a continuum between here and there, and now and then, the stories and photographs discussed in this chapter form dialectical images – images that refuse to be woven into a coherent picture of the past. By emphasising the dialectical ways these two individuals make sense of Mogadishu’s past and presence, I am following Walter Benjamin’s cue to rethink deeply modern analytical categories such as history, memory and temporality by highlighting the brief, fragmented moments of their appearance in everyday life.

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence.

Systematic consideration of scientific support is a critical element in developing and, ultimately, using adverse outcome pathways (AOPs) for various regulatory applications. Though weight of evidence (WoE) analysis has been proposed as a basis for assessment of the maturity and level of confidence in an AOP, methodologies and tools are still being formalized. The Organization for Economic Co-operation and Development (OECD) Users' Handbook Supplement to the Guidance Document for Developing and Assessing AOPs (OECD 2014a; hereafter referred to as the OECD AOP Handbook) provides tailored Bradford-Hill (BH) considerations for systematic assessment of confidence in a given AOP. These considerations include (1) biological plausibility and (2) empirical support (dose-response, temporality, and incidence) for Key Event Relationships (KERs), and (3) essentiality of key events (KEs). Here, we test the application of these tailored BH considerations and the guidance outlined in the OECD AOP Handbook using a number of case examples to increase experience in more transparently documenting rationales for assigned levels of confidence to KEs and KERs, and to promote consistency in evaluation within and across AOPs. The major lessons learned from experience are documented, and taken together with the case examples, should contribute to better common understanding of the nature and form of documentation required to increase confidence in the application of AOPs for specific uses. Based on the tailored BH considerations and defining questions, a prototype quantitative model for assessing the WoE of an AOP using tools of multi-criteria decision analysis (MCDA) is described. The applicability of the approach is also demonstrated using the case example aromatase inhibition leading to reproductive dysfunction in fish. Following the acquisition of additional experience in the development and assessment of AOPs, further refinement of parameterization of the model through expert elicitation is recommended. Overall, the application of quantitative WoE approaches hold promise to enhance the rigor, transparency and reproducibility for AOP WoE determinations and may play an important role in delineating areas where research would have the greatest impact on improving the overall confidence in the AOP.

The association between diabetes and hepatitis C: A systematic review of epidemiological evidence

Background. Several studies have proposed a link between type 2 Diabetes mellitus (DM2) and Hepatitis C infection (HCV) with conflicting results. Since DM2 and HCV have high prevalence, establishing a link between the two may guide further studies aimed at DM2 prevention. A systematic review was conducted to estimate the magnitude and direction of association between DM2 and HCV. Temporality was assessed from cohort studies and case-control studies where such information was available. ^ Methods. MEDLINE searches were conducted for studies that provided risk estimates and fulfill criteria regarding the definition of exposure (HCV) and outcomes (DM2). HCV was defined in terms of method of diagnosis, laboratory technique and method of data collection; DM2 was defined in terms of the classification [World Health Organization (WHO) and American Diabetes Association (ADA)] 1-3 used for diagnosis, laboratory technique and method of data collection. Standardized searches and data abstraction for construction of tables was performed. Unadjusted or adjusted measures of association for individual studies were obtained or calculated from the full text of the studies. Template designed by Dr. David Ramsey. ^ Results. Forty-six studies out of one hundred and nine potentially eligible articles finally met the inclusion and exclusion criteria and were classified separately based on the study design as cross-sectional (twenty four), case-control (fifteen) or cohort studies (seven). The cohort studies showed a three-fold high (confidence interval 1.66–6.29) occurrence of DM2 in individuals with HCV compared to those who were unexposed to HCV and cross sectional studies had a summary odds ratio of 2.53 (1.96, 3.25). In case control studies, the summary odds ratio for studies done in subjects with DM2 was 3.61 (1.93, 6.74); in HCV, it was 2.30 (1.56, 3.38); and all fifteen studies, together, yielded an odds ratio of 2.60 (1.82, 3.73). ^ Conclusion. The above results support the hypothesis that there is an association between DM and HCV. The temporal relationship evident from cohort studies and proposed pathogenic mechanisms also suggest that HCV predisposes patients to development of DM2. Further cohort or prospective studies are needed, however, to determine whether treatment of HCV infections prevents development of DM2.^

Is sexual violence associated with symptoms of depression and suicide attempts

Sexual assault, depression, and suicide are all very serious issues among youth today. This study sought to quantify the association between sexual violence, symptoms of depression, and suicide attempts through the use of 2007 Youth Risk Behavior Survey (YRBS) data. The YRBS is a nationally representative dataset of United States high school students, grades 9-12. It was hypothesized that sexual violence is significantly associated with symptoms of depression and suicide attempts. Through multivariate logistic regression, it was determined that students who had ever experienced forced sex were 3.10 (2.7-3.6) times as likely to be depressed, in the past 12 months, and 4.22 (3.5-5.1) times as likely to have attempted suicide. Female victims were 3.43 (2.9-4.0) times as likely to be depressed; male victims were 5.40 (3.7-7.9) times as likely to have attempted suicide. Sexual violence is significantly associated with both symptoms of depression and suicide attempt when stratified by gender, grade, and race/ethnicity. These results indicate that further study of the association between sexual violence and symptoms of depression and suicide attempts need to be conducted in order to establish temporality.^

El proyecto hermeneútico de Ser y Tiempo como contraproyecto filosófico al especulativo de la Fenomenología del Espíritu

El presente trabajo presenta en una visión sinóptica detallada el proyecto hermeneútico de Ser y Tiempo de Heidegger en expresa contraposición al proyecto especulativo de la Fenomenología del espíritu de Hegel. Tal oposición se muestra en la fundamentación inversa que expresamente propone Heidegger contra Hegel tanto en dicha obra como en sus lecciones y obras inmediatamente anteriores y posteriores a la misma sobre las cuestiones del ser, la finitud, la temporalidad y el acceso a las mismas, el problema del fenómeno. No obstante, estas cuatro cuestiones y su implicación problemática interna muestran también las notables convergencias de ambas obras, pues en ambas no sólo se trata de conducir el pensar hacia el ser por medio de un camino de fenómenos, sino también mostrar que dichos fenómenos son la justificación de derecho de un acceso al ser, es decir, son la justificación de derecho de la ontología. Finalmente, el trabajo busca una respuesta a tal contraposición filosófica consciente de Heidegger respecto de Hegel sobre el problema del ser y su accesibilidad concluyendo que una de las respuestas fundamentales reside en la diferencia en cómo un proyecto hermeneútico de tipo finitista y otro especulativo piensan la relación entre ser y ente.

Origen temporal y creación del mundo : la doble vía argumentativa de Tomás de Aquino

En medio de las disputas del siglo XIII, Tomás de Aquino afirma en el Commentarium in Sententiis, primera composición filosófico- teológica, que “a la creación no sólo se la alcanza a través de la fe, sino por la demostración racional". Esta idea no la abandona en ningún momento y la mantiene a lo largo de su obra. Constituye nuestro propósito en el presente trabajo establecer la relación existente entre la estrategia argumentativa que el autor desarrolla en torno a dos problemas: el de la creación y el del origen temporal del mundo, señalando las dos vías argumentativas utilizadas, una que concluye demostrativamente y la otra que expresa la imposibilidad de justificar racionalmente el tema. La clave argumentativa que según entendemos le permite diferenciar el doble orden de explicación radica en la distinción entre causas por sí y por accidente: una causa A está esencialmente ordenada a una causa B, si la acción de B es necesaria para que la acción de A haya tenido lugar. De modo que para alcanzar el efecto, es necesario admitir una causa primera, y entre los dos términos la distancia o el número de causas esencialmente ordenadas a la causa primera debe ser necesariamente finito. Distinto es el caso si se considera el orden de la temporalidad inscripto en el marco de la causalidad accidental: un mundo eterno o no, es algo que no se puede justificar racionalmente en cuanto es un efecto accidental que procede de una causa que obra con absoluta libertad. Entendemos que esta distinción es el instrumento conceptual que le permite a Aquino delimitar epistémicamente entre lo que es posible justificar con certeza, tal es el caso de las argumentaciones que ofrece en torno a la creación; lo que sólo lo es de modo probable, en particular las argumentaciones con base en las doctrinas físicas aristotélicas; y finalmente, aquello que el hombre únicamente puede llegar a conocer a través de la Revelación, como es el caso del conocimiento de un inicio temporal del mundo.

Un relámpago en la noche : interpretación de la relación entre temporalidad, amor y tiempo en F. W. J. Schelling

First, the article distinguishes, in Schelling´s philosophy, successivity and extaticoriginary temporality, and contends that the latter can be conceived as co-temporalization. Secondly, an analysis of loveis advanced as an experience in which co-temporalization is consummated, and it is shown how in the erotic pathos, through an empathic movement of overdetermination, the ecstases are sublated as such and “condensed" in an instant of eternity. Finally, the author differentiates temporality and the real-actual time that Schelling conceives as the continuity of discontinuous temporalities. Special attention is payed to the importance of Schelling´s thought for the current discussion on time.

La cuestión de la naturaleza y unicidad del tiempo en Alberto Magno : una aproximación al problema de las fuentes

En el presente trabajo nos proponemos analizar un tema que forma parte de la teoría física de Alberto Magno: la cuestión relativa a la naturaleza y unicidad del tiempo, considerada a partir del tratado De Tempore que forma parte de su comentario al libro IV de la Physica. Y lo haremos centrando nuestro interés en la problemática de las fuentes referidas –tácita o expresamente– por el Doctor Universalis en la evaluación del tema. Si bien Alberto despliega un amplio panorama en su evaluación que contempla tanto la doctrina de Agustín y de Galeno; como también la visión contrapuesta de Avicena, Alejandro, Themistio, Averroes, Teofrasto y Porfirio; todo su análisis apunta a indicar a Avicena y Averroes como los núcleos doctrinales que centralmente gravitan en la formulación del problema. Los peripatéticos medievales han substituido bajo el nombre del Estagirita una doctrina nueva vinculada, a partir de Avicena, muy íntimamente con el primer cielo y con el movimiento de la primera esfera como reloj universal y medida de todo movimiento. Al recurso de estas fuentes se suman también las aportaciones propias de Averroes, quien desarrolla una doctrina original que expone una conexión entre el tiempo y el esse transmutabile, considerando la temporalidad como el modo de ser propio de los seres materiales asociado a la conciencia del cambio continuo. Alberto elabora una doctrina propia, con base general en el sistema de Averroes, pero sin desconocer puntualizaciones de Avicena que resultan también asumidas en su original exposición filosófica.

Proceso de expansión urbana, actores y desigualdades

Este artículo busca analizar el proceso de expansión urbana de la ciudad de San Carlos de Bariloche, desde un enfoque de la especialidad y la temporalidad, con miras a comprender, desde sus lógicas de crecimiento, el actual contexto de profunda desigualdad urbana. Los distintos actores hegemónicos, los cuales fueron cambiando a lo largo del tiempo, han marcado el pulso de la urbanización, la expansión del ejido municipal y la aprobación de los loteos que contribuyeron a un crecimiento acelerado, descontrolado y especulativo. Entre ellos se destaca el Estado que desde distintas esferas instituciones, jurisdiccionales y funcionales, ostenta con determinado protagonismo su rol doble como agente y árbitro. Este estudio se ha realizado a partir de un profundo rastreo y análisis de fuentes documentales, muchas inéditas, vinculadas al desarrollo urbano barilochense, desde su fundación en 1902 hasta 2010. Así, con rupturas y continuidades, el crecimiento de esta ciudad media da cuenta de la notable importancia del estudio de los factores que definen modelos de desarrollo urbanos para comprender la complejidad del mosaico urbano actual y su posible mejoramiento.