Specimen paraphraseos primi capitis Exodi

Invokaatio: I.N.J.

Normal flow-mediated vasodilatation of the brachial artery and carotid artery intima-media thickness in subclinical hypothyroidism

Subclinical hypothyroidism (SHT) is a disease for which exact therapeutic approaches have not yet been established. Previous studies have suggested an association between SHT and coronary heart disease. Whether this association is related to SHT-induced changes in serum lipid levels or to endothelial dysfunction is unclear. The aim of this study was to determine endothelial function measured by the flow-mediated vasodilatation of the brachial artery and the carotid artery intima-media thickness (IMT) in a group of women with SHT compared with euthyroid subjects. Triglycerides, total cholesterol, HDL-C, LDL-C, apoprotein A (apo A), apo B, and lipoprotein(a) were also determined. Twenty-one patients with SHT (mean age: 42.4 ± 10.8 years and mean thyroid-stimulating hormone (TSH) levels: 8.2 ± 2.7 µIU/mL) and 21 euthyroid controls matched for body mass index, age and atherosclerotic risk factors (mean age: 44.2 ± 8.5 years and mean TSH levels: 1.4 ± 0.6 µIU/mL) participated in the study. Lipid parameters (except HDL-C and apo A, which were lower) and IMT values were higher in the common carotid and carotid bifurcation of SHT patients with positive serum thyroid peroxidase antibodies (TPO-Ab) (0.62 ± 0.2 and 0.62 ± 0.16 mm for the common carotid and carotid bifurcation, respectively) when compared with the negative TPO-Ab group (0.55 ± 0.24 and 0.58 ± 0.13 mm, for common carotid and carotid bifurcation, respectively). The difference was not statistically significant. We conclude that minimal thyroid dysfunction had no adverse effects on endothelial function in the population studied. Further investigation is warranted to assess whether subclinical hypothyroidism, with and without TPO-Ab-positive serology, has any effect on endothelial function.

De poësi Orphica, specimen academicum, quod venia ampl. fac. philos. Ab. Publico examini modeste subjiciunt mag. Johannes Jacob. Tengström historiae litterariae docens, ad bibliothecam acad. amanuensis extraord. et Robertus Tengström, Ostrobotnienses. In auditorio philos. die V Dec. MDCCCXII. h. a. m. s

Painovuosi nimekkeestä.

Moderate intensity physical training accelerates healing of full-thickness wounds in mice

Physical training influences the cells and mediators involved in skin wound healing. The objective of this study was to determine the changes induced by different intensities of physical training in mouse skin wound healing. Ninety male C57BL6 mice (8 weeks old, 20-25 g) were randomized into three physical training groups: moderate (70% VO2max), high (80% VO2max), and strenuous intensity (90% VO2max). Animals trained on a motorized treadmill for 8 weeks (Elesion: physical training until the day of excisional lesion, N = 10) or 10 weeks (Eeuthan: physical training for 2 additional weeks after excisional lesion until euthanasia, N = 10), five times/week, for 45 min. Control groups (CG) trained on the treadmill three times/week only for 5 min (N = 10). In the 8th week, mice were anesthetized, submitted to a dorsal full-thickness excisional wound of 1 cm², and sacrificed 14 days after wounding. Wound areas were measured 4, 7, and 14 days after wounding to evaluate contraction (d4, d7 and d14) and re-epithelialization (d14). Fragments of lesion and adjacent skin were processed and submitted to routine histological staining. Immunohistochemistry against alpha-smooth muscle actin (α-SMA) was performed. Moderate-intensity training (M) until lesion (M/Elesion) led to better wound closure 7 days after wounding compared to controls and M/Eeuthan (P < 0.05), and both moderate-intensity groups showed better re-epithelialization rates than controls (M/Elesion = 85.9%, M/Eeuthan = 96.4% and M/CG = 79.9%; P < 0.05). Sections of M/Elesion and M/Eeuthan groups stained with hematoxylin-eosin, Picrosirius red and α-SMA showed the most mature granulation tissues among all trained groups and controls. Thus, moderate-intensity physical training improves skin wound healing.

Specimen poëseos Pindaricae in latinum conversae 1

Arkit: A1-A3, A3-A4 [po. 1 arkintunnukseton lehti, A4] B4. - S. [2] tyhjä.

Specimen Alcorani arabice et latine 2

Invokaatio: D.D.

Specimen Alcorani arabice et latine 1

Invokaatio: D.D.

Specimen explicationis dicti Hebr. XI:1

Invokaatio: D.D.

Certitudinis, potiorum qvorundam, ex principiis primis practicis promanantium, officiorum, sciagraphicum specimen

Dedikaatio: Johannes Gezelius, Claes Jenderjan.

Analyseos sublimioris algebrae elementari connectendae specimen exhibens 1

Arkit: 1 arkintunnukseton lehti, A4 B3. - S. [2] tyhjä.

Analyseos sublimioris algebrae elementari connectendae specimen exhibens 4

Arkit: 1 arkintunnukseton lehti, E4 F1. - S. [2] tyhjä.

Analyseos sublimioris algebrae elementari connectendae specimen exhibens 3

Painovuosi nimekkeestä.

Analyseos sublimioris algebrae elementari connectendae specimen 5

Arkit: 1 arkintunnukseton lehti, G4. - S. [2] tyhjä.

Analyseos sublimioris algebrae elementari connectendae specimen exhibens 2

Dedikaatio: Pehr Gustaf von Delvig [ruots. pr.], Christ. Sophia von Delvig [ruots. pr.].

Specimen continens methodi residua, ex divisione numerorum oriunda, investigandi

Arkit: 1 arkintunnukseton lehti, A4 B3. - S. [2] ja [14] tyhjät.