Castigationes Plinianæ / Hermolai Barbari Aquileiensis Pontificis.

Huecos para iniciales con letras de aviso

Tractatus de autoritate Ro. Eccle. magistri Cypriani Beneti. [Texto impreso]

Hay un ejemplar encuadernado con: De prima Orbis Sede, de Concilio & Ecclesiastica potestate ac de S. D. N. Papa Supraemo insuperabiliq. dominio Opus (XVI/270).

Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors.

Exposure to exogenous alkylating agents, particularly N-nitroso compounds, has been associated with increased incidence of primary human brain tumors, while intrinsic risk factors are currently unknown. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is a major defense against the carcinogenicity of N-nitroso compounds and other alkylators. We report here that in 55% (64/117) of cases, histologically normal brain tissue adjacent to primary human brain tumors lacked detectable MGMT activity [methyl excision repair-defective (Mer-) status]. The incidence of Mer- status in normal brain tissue from brain tumor patients was age-dependent, increasing from 21% in children 0.25-19 years of age to 75% in adults over 50. In contrast, Mer- status was found in 12% (5/43) of normal brain specimens from patients operated for conditions other than primary brain tumors and was not age-dependent. The 4.6-fold elevation in incidence of Mer- status in brain tumor patients is highly significant (chi2 = 24; p < or = 0.001). MGMT activity was independent of age in the lymphocytes of brain tumor patients and was present in lymphocytes from six of nine tumor patients whose normal brain specimen was Mer-. DNA polymerase beta, apurinic/apyrimidinic endonuclease, and lactate dehydrogenase activities were present in all specimens tested, including Mer- specimens from brain tumor patients. Our data are consistent with a model of carcinogenesis in human brain in which epigenetically regulated lack of MGMT is a predisposing factor and alkylation-related mutagenesis is a driving force.

Jacobi Lopidis Stunicae Itinerarium ab Hispania vsq[ue] ad vrbem Romanã : in quo multa varia ac scitu dignissima cõtinent̃.

T.p. vignette is large woodcut of the author's arms.

Geberis ... Summa perfectionis magisterii in sua natura, ex bibliothecae Vaticanae exemplari vnde cumque emendatissimo nuper edita, cum quorumdam capitulorum, vasorum, & fornacum, in volumine alias mendosissime impresso ommissorum. Librique inuestigationis magisterii, & testamenti eiusdem Geberis, ac aurci.

Liber inuestigationis. Tetamentum Geberis philosophi. Liber trium verborum Kallid acutiss. Auicenae mineralia. Expositio epistolae Alexandri Regis. Opusculum authoris ignotis. Merlini allegoria. Rachaidibi &c. fragmentum.

Mariangeli Accursii Diatribae.

Edit16,

Antiquitates vrbis /

ICCU,

Alexandri Aphrodisiei Commentaria in duodecim Aristotelis libros de prima philosophia /

Edit16,

Colección de los viages y descubrimientos que hicieron por mar los españoles desde fines del siglo XV, con varios documentos inéditos concernientes á la historia de la marina castellana y de los establecimientos españoles en Indias,

diplomática. Observaciones sobre las anteriores probanzas. -- t.4 Poólogo. Noticia biográfica de Fernando de Magallanes. Viages al Maluco: Primero el de Hernando de Magallanes y Juan Sebastian de Elcano. Apédice de documentos pertenecientes á F. de Magallanes. -- t.5 Viages al Maluco: Segundo el del comemdador Fr. Garcia de Loaisa; tercero el de Alvaro de Saavedra. Apéndice de documentos.

Christophori Marcelli ... Exercitationes in septem primis psalmis.

CCPB,

Versuch über den gothischen Dativ.

Programm--Domgymnasium zu Naumburg.