Intimacy, sexual satisfaction and sexual distress in vulvodynia couples : an observational study

Note de l'éditeur : This article may not exactly replicate the final version published in the APA journal. It is not the copy of record. / Cet article ne constitue pas la version officielle, et peut différer de la version publiée dans la revue.

Cdk Activity Couples Epigenetic Centromere Inheritance to Cell Cycle Progression

Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A. Propagation of CENP-A chromatin is uncoupled from DNA replication initiating only during mitotic exit. We now demonstrate that inhibition of Cdk1 and Cdk2 activities is sufficient to trigger CENP-A assembly throughout the cell cycle in a manner dependent on the canonical CENP-A assembly machinery. We further show that the key CENP-A assembly factor Mis18BP1(HsKNL2) is phosphorylated in a cell cycle-dependent manner that controls its centromere localization during mitotic exit. These results strongly support a model in which the CENP-A assembly machinery is poised for activation throughout the cell cycle but kept in an inactive noncentromeric state by Cdk activity during S, G2, and M phases. Alleviation of this inhibition in G1 phase ensures tight coupling between DNA replication, cell division, and subsequent centromere maturation.

Intimacy, sexual satisfaction and sexual distress in vulvodynia couples : an observational study

Note de l'éditeur : This article may not exactly replicate the final version published in the APA journal. It is not the copy of record. / Cet article ne constitue pas la version officielle, et peut différer de la version publiée dans la revue.

Elegant Couples Courting

Willem Pietersz. Buytewech; 1 ft. 10 11/64 in.x 2 ft. 3 3/4 in.; oil on canvas

Report on marine atmosphere exposure of galvanic couples involving magnesium,

Mode of access: Internet.

Lovers, from a Picture-book Models of Couples (Ehon tsuhi no hinagata)

Katsushika Hokusai; 10 7/16 in.x 1 ft. 3 23/64 in.; woodcut on paper

Nursing home services and information for couples.

"(R-06-07)"--Colophon.

The Garden of Earthly Delights Triptych, interior, center panel, lower portion, Birds and Couples: detail

Hieronymus Bosch; grisaille, oil on wood

The Garden of Earthly Delights Triptych, interior, center panel, lower portion, Birds and Couples, Couples in Bubble Flower

Hieronymus Bosch; grisaille, oil on wood

The Garden of Earthly Delights Triptych, interior, center panel, lower portion, Birds and Couples: Topsy-Turvy Man

Hieronymus Bosch; grisaille, oil on wood

The Garden of Earthly Delights Triptych, interior, center panel, lower portion, Birds and Couples: detail

Hieronymus Bosch; grisaille, oil on wood

Couples dancing at the Little Club

Daybook, image #12