858 resultados para Ricardo Rojas
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Letras - IBILCE
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Letras - FCLAS
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Pós-graduação em Serviço Social - FCHS
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Processes that promote cancer progression such as angiogenesis require a functional interplay between malignant and nonmalignant cells in the tumor microenvironment. The metalloprotease aminopeptidase N (APN; CD13) is often overexpressed in tumor cells and has been implicated in angiogenesis and cancer progression. Our previous studies of APN-null mice revealed impaired neoangiogenesis in model systems without cancer cells and suggested the hypothesis that APN expressed by nonmalignant cells might promote tumor growth. We tested this hypothesis by comparing the effects of APN deficiency in allografted malignant (tumor) and nonmalignant (host) cells on tumor growth and metastasis in APN-null mice. In two independent tumor graft models, APN activity in both the tumors and the host cells cooperate to promote tumor vascularization and growth. Loss of APN expression by the host and/or the malignant cells also impaired lung metastasis in experimental mouse models. Thus, cooperation in APN expression by both cancer cells and nonmalignant stromal cells within the tumor microenvironment promotes angiogenesis, tumor growth, and metastasis.
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Premio extraordinario, Área de Experimentales.
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Se estudia el papel de la poliaminas durante la reproducción de las algas rojas , en particular la de las enzimas reguladoras de su síntesis ornitina descarboxilasa y arginina descarboxilasa
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[ES] Se observa un efecto claro de la temperatura del agua sobre la tasa respiratoria aérea de crías de Trachemys scripta elegans (Wied, 1838), de modo que ésta se incrementa de forma directa con el aumento de la temperatura de 17 a 28 ºC. Además, a temperaturas bajas (17 ºC) la tasa de actividad es también más baja, permaneciendo más tiempo inmóviles