Three-dimensional primary stability of cementless femoral stems

OBJECTIVE: This study investigates by means of a new bone-prosthesis interface motion detector whether conceptual design differences of femoral stems are reflected in their primary stability pattern. DESIGN: An in vitro experiment using a biaxial materials testing machine in combination with three-dimensional motion measurement devices was performed. BACKGROUND: Primary stability of uncemented total hip replacements is considered to be a prerequisite for the quality of bony ongrowth to the femoral stem. Dynamic motion as a response to loading as well as total motion of the prosthesis have to be considered under quasi-physiological cyclic loading conditions. METHODS: Seven paired fresh cadaveric femora were used for the testing of two types of uncemented femoral stems with different anchoring concepts: CLS stem (Spotorno) and Cone Prosthesis (Wagner). Under sinusoidal cyclic loading mimicking in vivo hip joint forces a new measurement technique was applied allowing for the analysis of the three-dimensional interface motion. RESULTS: Considerable differences between the two prostheses could be detected both in their dynamic motion and total motion behaviour. Whereas the CLS stem, due to the wedge-shaped concept, provides smaller total motions, the longitudinal ribs of the Cone prostheses result in a substantially smaller dynamic motion. CONCLUSIONS: The measuring technique provided reliable and accurate data illustrating the three-dimensional interface motion of uncemented femoral stems.

Relative Value of White Corn When Fed to Finishing Cattle and Its Effects on Color of Carcass Fat

White corn was compared with yellow corn in a 180-day finishing trial with 600 lb. Angus steers fed 90% concentrate diets. Steers fed yellow corn consumed 3.3% less feed and were 3.8% more efficient in feed utilization. Rate of gain and carcass characteristics were similar for steers fed white or yellow corn. The color of subcutaneous fat over the ribs was significantly whiter from carcasses of steers fed white corn compared with those fed yellow corn. The results of this study indicate that white corn may be used instead of barley to produce whiter fat in beef carcasses.

A dosimetric study of radionuclide therapy for bone marrow ablation

In a phase I clinical trial, six multiple myeloma patients, who were non-responsive to conventional therapy and were scheduled for bone marrow transplantation, received Holmium-166 ($\sp{166}$Ho) labeled to a bone seeking agent, DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene-phosphonic acid), for the purpose of bone marrow ablation. The specific aims of my research within this protocol were to evaluate the toxicity and efficacy of $\sp{166}$Ho DOTMP by quantifying the in vivo pharmacokinetics and radiation dosimetry, and by correlating these results to the biologic response observed. The reproducibility of pharmacokinetics from multiple injections of $\sp{166}$Ho DOTMP administered to these myeloma patients was demonstrated from both blood and whole body retention. The skeletal concentration of $\sp{166}$Ho DOTMP was heterogenous in all six patients: high in the ribs, pelvis, and lumbar vertebrae regions, and relatively low in the femurs, arms, and head.^ A novel technique was developed to calculate the radiation dose to the bone marrow in each skeletal ROI, and was applied to all six $\sp{166}$Ho DOTMP patients. Radiation dose estimates for the bone marrow calculated using the standard MIRD "S" factors were compared with the average values derived from the heterogenous distribution of activity in the skeleton (i.e., the regional technique). The results from the two techniques were significantly different; the average of the dose estimates from the regional technique were typically 30% greater. Furthermore, the regional technique provided a range of radiation doses for the entire marrow volume, while the MIRD "S" factors only provided a single value. Dose volume histogram analysis of data from the regional technique indicated a range of dose estimates that varied by a factor of 10 between the high dose and low dose regions. Finally, the observed clinical response of cells and abnormal proteins measured in bone marrow aspirates and peripheral blood samples were compared with radiation dose estimates for the bone marrow calculated from the standard and regional technique. The results showed the regional technique values correlated more closely to several clinical response parameters. (Abstract shortened by UMI.) ^

Complementary passive hydrotherapy WATSU (WaterShiatsu) in the rehabilitation of a severely traumatized accident survivor – A prospective case report

Introduction: The implementation of complementary and alternative therapies into conventional treatment schemes is gaining popularity. However, their use is widely depending on patients’ drive. This case-report focuses on a patient’s experience of the integration of WATSU (WaterShiatsu) in rehabilitative care. Methods: Patient: A 52 year old woman survived a severe motorcycle-accident in which she sustained several fractures on the right side of her body, including ribs, pelvis, and femur. After discharge from stationary care, she independently added WATSU to her rehabilitative regimen. Treatment approach: WATSU is a passive form of hydrotherapy in warm water that aims at relaxation, pain relief, and a sense of secureness. In the reported case, an experienced WATSU-therapist who is also trained in physiotherapy and psychosomatics delivered weekly sessions of one hour duration. Measures used: Qualitative data were collected by patient’s diary. Also the therapist’s notes including The Patient Specific Functional Scale (PSFS) were considered. Results: The patient associated WATSU with trunk mobilization (followed by ameliorated breath), reconciliation with her body, and emotional discharge. She ascribed WATSU lasting effects on her body-image. The therapist employed WATSU for careful mobilization and to equalize awareness throughout the body. The PSFS displayed continuous improvement in all categories except usage of public transportation. Due to complications (elevated inflammation markers) only 6 of 8 scheduled sessions were administered. Conclusions: WATSU was experienced helpful in approaching conditions that are difficult to address by conventional physiotherapy. In early rehabilitation, additional medical/physiotherapeutic skills of contributing complementary therapists are advocated.

Metamorphosis of human lumbar vertebrae induced by VEPTR growth modulation and stress shielding

INTRODUCTION Distraction-based spinal growth modulation by growing rods or vertical expandable prosthetic titanium ribs (VEPTRs) is the mainstay of instrumented operative strategies to correct early onset spinal deformities. In order to objectify the benefits, it has become common sense to measure the gain in spine height by assessing T1-S1 distance on anteroposterior (AP) radiographs. However, by ignoring growth changes on vertebral levels and by limiting measurement to one plane, valuable data is missed regarding the three-dimensional (3D) effects of growth modulation. This information might be interesting when it comes to final fusion or, even more so, when the protective growing implants are removed and the spine re-exposed to physiologic forces at the end of growth. METHODS The goal of this retrospective radiographic study was to assess the growth modulating impact of year-long, distraction-based VEPTR treatment on the morphology of single vertebral bodies. We digitally measured lumbar vertebral body height (VBH) and upper endplate depth (VBD) at the time of the index procedure and at follow-up in nine patients with rib-to-ileum constructs (G1) spanning an anatomically normal lumbar spine. Nine patients with congenital thoracic scoliosis and VEPTR rib-to-rib constructs, but uninstrumented lumbar spines, served as controls (G2). All had undergone more than eight half-yearly VEPTR expansions. A Wilcoxon signed-rank test was used for statistical comparison of initial and follow-up VBH, VBD and height/depth (H/D) ratio (significance level 0.05). RESULTS The average age was 7.1 years (G1) and 5.2 year (G2, p > 0.05) at initial surgery; the average overall follow-up time was 5.5 years (p = 1). In both groups, VBH increased significantly without a significant intergroup difference. Group 1 did not show significant growth in depth, whereas VBD increased significantly in the control group. As a consequence, the H/D ratio increased significantly in group 1 whereas it remained unchanged in group 2. The growth rate for height in mm/year was 1.4 (group 1) and 1.1 (group 2, p = 0.45), and for depth, it was -0.3 and 1.1 (p < 0.05), respectively. CONCLUSIONS VEPTR growth modulating treatment alters the geometry of vertebral bodies by increasing the H/D ratio. We hypothesize that the implant-related deprivation from axial loads (stress-shielding) impairs anteroposterior growth. The biomechanical consequence of such slender vertebrae when exposed to unprotected loads in case of definitive VEPTR removal at the end of growth is uncertain.

New osseous soft markers for trisomy 13, 18 and 21

INTRODUCTION For ultrasonographic diagnosis of a fetal trisomy so-called "soft markers" (=ultrasonographically detectable morphological variants) are used. Detection of a certain number of them increases the diagnostic certainty of a fetal trisomy. Up to now there are very few diagnostically accepted osseous soft markers for trisomy. Hence potential osseous soft markers applicable for first and second trimester ultrasound screening for trisomy 21, 18 or 13 were studied. METHODS Postmortal fetal X-rays (ap, lateral) of 358 fetuses (trisomy 21: n = 109, trisomy 18: n = 46; trisomy 13: n = 38, control group: n = 165). RESULTS Not yet described but with trisomy 21 statistically associated soft markers were un-timely os sternale ossification, delayed os sacrum ossification, shortened os maxillare, reduced os maxillare-jaw-corner distance, augmented orbita height, premature os calcaneus ossification, bell-shaped thorax, coronal clefts, trend to wider binocular as well as wider intraocular distances; for trisomy 18: elevated clavicula slope, reduced number of ribs, bell-shaped thorax, coronal clefts, reduced os maxillare-jaw-corner distance, shortened ramus mandibulare, shortened os metacarpale IV and V, augmented ratio between biparietal diameter and (osseus and soft-tissue) shoulder width; for trisomy 13: longer os nasale, elevated clavicula slope, premature sternum, delayed os sacrum ossification, delayed/premature cranium ossification, reduced number of ribs, coronal clefts, reduced os maxillare-jaw-corner distance, shortened ramus mandibulare, augmented orbita height, shortened os metacarpale V and a tendency for a shortened os metacarpale IV. CONCLUSION We found several not yet published osseous soft markers statistically associated with trisomy 21, 18 and 13, which can help to ensure sonographically these aneuploidy diagnoses.

Cloning and molecular analysis of paraxis: A {\it trans\/}-acting factor required for somite maturation

During vertebrate embryogenesis, cells from the paraxial mesoderm coalesce in a rostral-to-caudal progression to form the somites. Subsequent compartmentalization of the somites yields the sclerotome, myotome and dermatome, which give rise to the axial skeleton, axial musculature, and dermis, respectively. Recently, we cloned a novel basic-Helix-Loop-Helix (bHLH) protein, called scleraxis, which is expressed in the sclerotome, in mesenchymal precursors of bone and cartilage, and in connective tissues. This dissertation focuses on the cloning, expression and functional analysis of a bHLH protein termed paraxis, which is nearly identical to scleraxis within the bHLH region but diverges in both its amino and carboxyl termini. During the process of mouse embryogenesis, paraxis transcripts are first detected at about day 7.5 post coitum within the primitive mesoderm lying posterior to the head and heart primordia. Subsequently, paraxis expression progresses caudally through the paraxial mesoderm, immediately preceding somite formation. Paraxis is expressed at high levels in newly formed somites before the first detectable expression of the myogenic bHLH genes, and as the somite becomes compartmentalized, paraxis becomes downregulated within the myotome.^ To determine the function of paraxis during mammalian embryogenesis, mice were generated with a null mutation in the paraxis locus. Paraxis null mice survived until birth, but exhibited severe foreshortening along the anteroposterior axis due to the absence of vertebrae caudal to the midthoracic region. The phenotype also included axial skeletal defects, particularly shortened bifurcated ribs which were detached from the vertebral column, fused vertebrae and extensive truncation and disorganization caudal to the hindlimbs. Mutant neonates also lacked normal levels of trunk muscle and exhibited defects in the dermis as well as the stratification of the epidermis. Analysis of paraxis -/- mutant embryos has revealed a failure of the somites to both properly epithelialize and compartmentalize, resulting in defects in somite-derived cell lineages. These results suggest that paraxis is an essential component of the genetic pathway regulating somitogenesis. ^

(Tables 1-15) Morphometric characteristics of the genus Hinia (Nassariidae, Gastropoda) in the Tertiary of northwest Germany

The genus Hinia is divided in 4 subgenera; other subgenera are not represented in the area studied. It was possible to find criteria for a better discrimination of the highly variable species H. (Hinia) schlotheimi and H. (Hinia) turbinella. The species "fuchsi" has been placed in the synonymy of H. (Hinia) turbinella. The species H. (Hinia) schlotheimi (BEYRICH) and H. (Telasco) schroederi (KAUTSKY) have been united under the name H. (Hinia) schlotheimi. The easily distinguishable species H. (Tritonella) tenuistriata and H. (Hinia) sulcata belong to two different genera. H. (Tritonella) cimbrica andersoni of the Viol- and Katzheide-Beds (Reinbek-stage) is separable from the population found in the Hemmoor-stage, it turned out to be a valuable guide subspecies for the Reinbek-stage. The species H. (Tritonella) serraticosta, H. (Tritonella) catulli, H. (Hinia) holsatica, and H. (Telasco) syltensis are all similar in respect to shape and ornamentation. Criteria have been found for a better discrimination of these species. The species contabulata, effusa and seminodifera described by SPEYER (1864), turned out to be contogenetic stages of H. (Tritonella) pygmaea. H. (Tritonella) cavata, previously described from the Tertiary of the North sea area, was proven to be absent from the area investigated. The forms described under that name, belong to H. (Tritonella) woodwardi.

Contents of major components, U, and Th in bones and bone debris

Uranium and thorium contents, as well as their distribution patterns have been studied in biogenic phosphates from the Atlantic and Pacific Oceans. Differently lithified fish remains (bones, scales, teeth) and marine mammal bones (ribs, vertebras, earbones) collected from both reduced shelf sediments and oxidized pelagic ones have been analyzed. U content in the material varies from 0.7 to 700 ppm, and Th content - from <0.5 to 14 ppm. U/Th ratio varies from 0.16 to 400. Contents of both elements increase with lithification of biogenic phosphates. U concentration is more intense on shelves, whereas thorium concentration increases in pelagic areas. Partial positive correlation of U and Th with Fe and negative correlation of U with organic carbon are noted. The latter corresponds to higher lithification of biogenic phosphates. Calcium phosphate transformed from hydroxyapatite to fluorcarbonate-apatite is the main carrier of U, while transformed organic matter is a minor agent. Thorium is mainly bound with Fe.

Structural Analysis of Thin Tile Vaults and Domes: The Inner Oval Dome of the Basilica de los Desamparados in Valencia

The inner oval dome of the Basílica de la Virgen los Desamparados, built in 1701, is one of the most slender masonry vaults ever built. It is a tile dome with a total thickness of 80 mm and a main span of 18.50 m. It was built without centering with great ingenuity and economy of means, thirty three years after the termination of the building in 1667. The dome is in contact with the external dome only in the inferior part with the projecting ribs of the intrados, the lunettes of the windows, and, in the upper part, through 126 inclined iron bars. This unique construction was revealed in the 1990's in the studies previous to the restoration of the Basílica, and has given rise to different theories about the mode of construction and the structural behaviour and safety of the dome. The present contribution aims to provide a plausible hypothesis about the mode of construction and to explain the safety of the inner dome which has stood, without need of repairs or reinforcement, for 300 hundred years.

The Islamic Crossed-Arch Domes in Cordoba: Geometry and Structural Analysis of the “Capilla de Villaviciosa”

Crossed-arch domes are a singular type of ribbed vaults. Their characteristic feature is that the ribs that form the vault are intertwined, forming polygons or stars, leaving an empty space in the centre. The earliest known vaults of this type are found in the Great Mosque of Córdoba, built ca. 960 a.C. The type spread through Spain, and the north of Africa in the 10th to the 16th Centuries, and was used by Guarini and Vittone in the 17th and 18th Centuries in Italy. However, it was used only in a few buildings. Though the literature about the structural behaviour of ribbed Gothic vaults is extensive, so far no structural analysis of crossed arch domes has been made. The purpose of this work is, first to show the way to attack such an analysis within the frame of Modern Limit Analysis of Masonry Structures (Heyman 1995), and then to apply the approach to study the stability of the dome of the Capilla de Villaviciosa. The work may give some clues to art and architectural historians to understand better the origin and development of Islamic dome architecture.

Improving probabilistic flood forecasting through a data assimilation scheme based on genetic programming

Opportunities offered by high performance computing provide a significant degree of promise in the enhancement of the performance of real-time flood forecasting systems. In this paper, a real-time framework for probabilistic flood forecasting through data assimilation is presented. The distributed rainfall-runoff real-time interactive basin simulator (RIBS) model is selected to simulate the hydrological process in the basin. Although the RIBS model is deterministic, it is run in a probabilistic way through the results of calibration developed in a previous work performed by the authors that identifies the probability distribution functions that best characterise the most relevant model parameters. Adaptive techniques improve the result of flood forecasts because the model can be adapted to observations in real time as new information is available. The new adaptive forecast model based on genetic programming as a data assimilation technique is compared with the previously developed flood forecast model based on the calibration results. Both models are probabilistic as they generate an ensemble of hydrographs, taking the different uncertainties inherent in any forecast process into account. The Manzanares River basin was selected as a case study, with the process being computationally intensive as it requires simulation of many replicas of the ensemble in real time.

Late Gothic German Vault Design Methods and Its Relationship with Spanish Ribbed Vaults

The arrival of European master masons to Burgos and Toledo during the mid-fifteenth century was essential for the promotion of the late Gothic ribbed vault design techniques in Spain. The Antigua Chapel in Seville Cathedral, designed by the Spanish master mason Simón de Colonia on 1497, provides an outstanding case study on this subject. This vault is characterized by the interlacing of the ribs near the springing, reflecting the influence of German ribbed vault designs. This paper analyses the relationship between German ribbed vaults and their design methods with those of Spanish ribbed vaults; with particular attention to the presence of ribs that cut through one another above the springing, materialized in the work of Simón de Colonia. This characteristic is reflected in some manuscripts in the German area, like the Wiener Sammlungen (15th-16th centuries) and the Codex Miniatus 3 (ca. 1560-1570), but no Spanish documents of the same period make reference to it.

The Irregular Ribbed Vault of the Sacristy of the Cathedral of Saint-Jean Baptiste in Perpignan

The vault of the sacristy of the Cathedral of Saint-Jean Baptiste in Perpignan (France), constructed by the Majorcan architect Guillem Sagrera between 1433 and 1447, is an outstanding, yet strikingly unknown, example of rib vaulting. This paper analyzes the overall construction of the form of the vault, characterized by its highly irregular perimeter, with particular attention to an isolated decorated corbel which solves the problem of the wall support of a group of six ribs and is in stark contrast with the rest of the supports, which are completely unadorned. Given the extreme rigour of Sagrera in all his works (and this one in particular), this apparent “capriccio” must be justified not only by decorative or formal requirements, but also by the constructive logic of Gothic vaulting system

La barrera del análisis estructural y la representación gráfica en el desarrollo de los proyectos arquitectónicos: el caso de la Ópera de Sidney

En numerosas ocasiones a lo largo de la historia la imaginación de los creadores ha ido por delante de las posibilidades técnicas de cada momento. Así, muchas de estas nuevas ideas han requerido largos periodos de tiempo para materializarse como realidad construida, hasta que el desarrollo tecnológico e industrial hubo alcanzado un grado de madurez suficiente. En el campo de la arquitectura, estas limitaciones técnicas se han ido acotando paulatinamente hasta desembocar en la situación actual en la que cualquier planteamiento formal puede ser representado gráficamente y analizado desde un punto de vista estructural, superádose de este modo la barrera existente históricamente en el tratamiento de las formas. A lo largo del presente tesis doctoral se analiza cómo la formulación del Método de los Elementos Finitos en la década de los cincuenta y las curvas de Bézier en la década de los sesenta del siglo pasado y la posterior generalización de los ordenadores personales y de los programas informáticos asociados (C.A.D. y F.E.M. principalmente) en los estudios de arquitectura e ingeniería a partir de la década de los noventa, posibilitó el desarrollo de cualquier propuesta arquitectónica, por compleja que ésta fuese, provocando una verdadera revolución a nivel formal en el mundo de la arquitectura, especialmente en el campo de la edificación singular o icónica. Se estudia este proceso a través de ocho edificios; cuatro anteriores y otros tantos posteriores a la desaparición de la barrera anteriormente referida, establecida de forma simbólica en la década de los años ochenta del siglo XX: Frontón de Recoletos en Madrid, Edificio Seagram en Nueva York, Habitat ’67 en Montreal, Ópera de Sídney, museo Guggenheim de Bilbao, ampliación del Victoria & Albert Museum en Londres, tanatorio “Meiso no Mori” en Gifu y nueva sede de la CCTV en Pekín. De entre ellos, la Ópera de Sídney, obra del arquitecto danés Jørn Utzon, condensa gran parte de los aspectos relevantes investigados en relación a la influencia que los métodos de representación y análisis estructural ejercen en la concepción y construcción de las obras de arquitectura. Por este motivo y por considerarse un hito de la arquitectura a nivel global se toma como caso de estudio. La idea general del edificio, que data de 1956, se enmarca en una época inmediatamente anterior a la del desarrollo científico y tecnológico anteriormente referido. Esta ausencia de herramientas de diseño disponibles acordes a la complejidad formal de la propuesta planteada condicionó enormente la marcha del proyecto, dilatándose dramáticamente en el tiempo y disparándose su coste hasta el punto de que el propio arquitecto danés fue separado de las obras antes de su conclusión. Además, la solución estructural finalmente construida de las cubiertas dista mucho de la prevista por Utzon inicialmente. Donde él había imaginado unas finas láminas de hormigón flotando sobre el paisaje se materializó una estructura más pesada, formada por costillas pretensadas de hormigón con unas secciones notablemente mayores. La forma también debió ser modificada de modo ostensible respecto a la propuesta inicial. Si este edificio se pretendiese construir en la actualidad, con toda seguridad el curso de los acontecimientos se desarrollaría por senderos muy diferentes. Ante este supuesto, se plantean las siguientes cuestiones: ¿sería posible realizar un análisis estructural de la cubierta laminar planteada por Utzon inicialmente en el concurso con las herramientas disponibles en la actualidad?; ¿sería dicha propuesta viable estructuralmente?. A lo largo de las siguientes páginas se pretende dar respuesta a estas cuestiones, poniendo de relieve el impacto que los ordenadores personales y los programas informáticos asociados han tenido en la manera de concebir y construir edificios. También se han analizado variantes a la solución laminar planteada en la fase de concurso, a través de las cuales, tratando en la medida de lo posible de ajustarse a las sugerencias que Ove Arup y su equipo realizaron a Jørn Utzon a lo largo del dilatado proceso de proyecto, mejorar el comportamiento general de la estructura del edificio. Por último, se ha pretendido partir de cero y plantear, desde una perspectiva contemporánea, posibles enfoques metodológicos aplicables a la búsqueda de soluciones estructurales compatibles con la forma propuesta originalmente por Utzon para las cubiertas de la Ópera de Sídney y que nunca llegó a ser construida (ni analizada), considerando para ello los medios tecnológicos, científicos e industriales disponibles en la actualidad. Abstract On numerous occasions throughout history the imagination of creators has gone well beyond of the technical possibilities of their time. Many new ideas have required a long period to materialize, until the technological and industrial development had time to catch up. In the architecture field, these technical limitations have gradually tightened leading to the current situation in which any formal approach can be represented and analyzed from a structural point of view, thus concluding that the structural analysis and the graphical representation’s barrier in the development of architectural projects has dissappeared. Throughout the following pages it is examined how the development of the Finite Element Method in the fifties and the Bezier curves in the sixties of the last century and the subsequent spread of personal computers and specialized software in the architectural and engineering offices from the nineties, enabled the development of any architectural proposal independently of its complexity. This has caused a revolution at a formal level in architecture, especially in the field of iconic building. This process is analyzed through eight buildings, four of them before and another four after the disappearance of the above mentioned barrier, roughly established in the eighties of the last century: Fronton Recoletos in Madrid, Seagram Building in New York Habitat '67 in Montreal, Sydney Opera House, Guggenheim Museum Bilbao, Victoria & Albert Museum extension in London, Crematorium “Meiso no Mori” in Gifu and the new CCTV headquarters in Beijing. Among them, the Sydney Opera House, designed by Danish architect Jørn Utzon, condenses many of the main aspects previously investigated regarding the impact of representation methods and structural analysis on the design and construction of architectural projects. For this reason and also because it is considered a global architecture milestone, it is selected as a case study. The building’s general idea, which dates from 1956, is framed at a time immediately preceding the above mentioned scientific and technological development. This lack of available design tools in accordance with the proposal’s formal complexity conditioned enormously the project’s progress, leading to a dramatic delay and multiplying the final budget disproportionately to the point that the Danish architect himself was separated from the works before completion. Furthermore, the built structure differs dramatically from the architect’s initial vision. Where Utzon saw a thin concrete shell floating over the landscape a heavier structure was built, consisting of prestressed concrete ribs with a significantly greater size. The geometry also had to be modified. If this building were to built today, the course of events surely would walk very different paths. Given this assumption, a number of questions could then be formulated: Would it be possible to perform a structural analysis of Utzon’s initially proposed competition-free-ways roof’s geometry with the tools available nowadays?; Would this proposal be structurally feasable?. Throughout the following pages it is intended to clarify this issues, highlighting personal computers and associated software’s impact in building design and construction procedures, especially in the field of iconic building. Variants have also been analyzed for the laminar solution proposed in the competition phase, through which, trying as far as possible to comply with the suggestions that Ove Arup and his team did to Jørn Utzon along the lengthy process project, improving the overall performance of the building structure. Finally, we have started from scratch and analyzed, from a contemporary perspective, possible structural solutions compatible with Utzon’s Opera House’s original geometry and vision –proposal that was never built (nor even analyzed)-, taking into consideration the technological, scientific and industrial means currently available.