Impact of body mass index on long-term clinical outcomes after second-generation drug eluting stent implantation: Insights from the international global RESOLUTE program

BACKGROUND An increased body mass index (BMI) is associated with a high risk of cardiovascular disease and reduction in life expectancy. However, several studies reported improved clinical outcomes in obese patients treated for cardiovascular diseases. The aim of the present study is to investigate the impact of BMI on long-term clinical outcomes after implantation of zotarolimus eluting stents. METHODS Individual patient data were pooled from the RESOLUTE Clinical Program comprising five trials worldwide. The study population was sorted according to BMI tertiles and clinical outcomes were evaluated at 2-year follow-up. RESULTS Data from a total of 5,127 patients receiving the R-ZES were included in the present study. BMI tertiles were as follow: I tertile (≤ 25.95 kg/m(2) -Low or normal weight) 1,727 patients; II tertile (>25.95 ≤ 29.74 kg/m(2) -overweight) 1,695 patients, and III tertile (>29.74 kg/m(2) -obese) 1,705 patients. At 2-years follow-up no difference was found for patients with high BMI (III tertile) compared with patients with normal or low BMI (I tertile) in terms of target lesion failure (I-III tertile, HR [95% CI] = 0.89 [0.69, 1.14], P = 0.341; major adverse cardiac events (I-III tertile, HR [95% CI] = 0.90 [0.72, 1.14], P = 0.389; cardiac death (I-III tertile, HR [95% CI] = 1.20 [0.73, 1.99], P = 0.476); myocardial infarction (I-III tertile, HR [95% CI] = 0.86 [0.55, 1.35], P = 0.509; clinically-driven target lesion revascularization (I-III tertile, HR [95% CI] = 0.75 [0.53, 1.08], P = 0.123; definite or probable stent thrombosis (I-III tertile, HR [95% CI] = 0.98 [0.49, 1.99], P = 0.964. CONCLUSIONS In the present study, the patients' body mass index was found to have no impact on long-term clinical outcomes after coronary artery interventions.

Sequence verification of human creatine kinase (43 kDa) isozymes by high-resolution tandem mass spectrometry.

Amino acid sequencing by recombinant DNA technology, although dramatically useful, is subject to base reading errors, is indirect, and is insensitive to posttranslational processing. Mass spectrometry techniques can provide molecular weight data from even relatively large proteins for such cDNA sequences and can serve as a check of an enzyme's purity and sequence integrity. Multiply-charged ions from electrospray ionization can be dissociated to yield structural information by tandem mass spectrometry, providing a second method for gaining additional confidence in primary sequence confirmation. Here, accurate (+/- 1 Da) molecular weight and molecular ion dissociation information for human muscle and brain creatine kinases has been obtained by electrospray ionization coupled with Fourier-transform mass spectrometry to help distinguish which of several published amino acid sequences for both enzymes are correct. The results herein are consistent with one published sequence for each isozyme, and the heterogeneity indicated by isoelectric focusing due to 1-Da deamidation changes. This approach appears generally useful for detailed sequence verification of recombinant proteins.

Account book, 1780-1802 (inclusive)

Account book of the Rev. John Lathrop, who was minister of the Second Church in Boston (Old North Church) from 1768 to 1816.

National urban mass transportation statistics. Second annual report, section 15 reporting system.

Urban Mass Transportation Administration, Washington, D.C.

The church and the age : essays on the principles and present position of the Anglican Church : second series /

Includes bibliographical references.

In the council, regular session 1913-14 : Council Bill no. 255, introduced by Mr. Fletcher : first reading Oct 31, 1913; second reading Nov. 4, 1913; referred to Committee on Legislation : An ordinance [regarding motion pictures].

Bostwick, A.L. Censorship of motion picture films. Report to the City Council; p. 5-17.

Iran's ballistic missile and weapons of mass destruction programs : hearing before the Subcommittee on International Security, Proliferation, and Federal Services of the Committee on Governmental Affairs, United States Senate, One Hundred Sixth Congress, second session, September 21, 2000.

Shipping list no.: 2001-0124-P.

Juvenile delinquency (Boston, Mass.) : hearings before the Subcommittee to Investigate Juvenile Delinquency of the Committee on the Judiciary, United States Senate, Eighty-third Congress, second session, pursuant S. Res. 89, invesitagion of juvenile delinquency in the United States, January 28, 29, and 30, 1954.

Robert C. Hendrickson, chairman of subcommittee.

Mass transit development for small urban areas: a case study - Tompkins County, N.Y. Second-year final report.

Transportation Department, Office of University Research, Washington, D.C.