Zur Eröffnung der Untergrundbahn nach Westend; Überblick über Vorgeschichte und Bauausführung der Bahn;

Mode of access: Internet.

Die Rezesse zwischen Sachsen und Schönburg. Leipziger juristische Inauguraldissertation.

Bibliography: p. [119]-120.

Ueber die Authenticität des kanonischen Evangeliums nach Matthäus benannt : aus und nach dessen hinterlassenen Patieren herausgegeben von D.J.T.L. Danz /

Includes bibliographical references.

Die frauen in der geschichte des deutschen geisteslebens des 18. und 19. jahrhunderts,

"Quellen-nachweis": v. 1, p. [333]-353; v. 2, p. [441]-451.

Uber Phosphorvanadinmolybdate /

Thesis (doctoral)--Universitat Bern, 1900.

Ammoniak-Partialdrucke uber ammoniakalischen Metalllsalzlosungen : ein Beitrag zur Elektroafinitatstheorie /

Thesis (doctoral)--Konigl. Universitat Breslau, 1900.

Uber das Spratzen der sauren Vanadate einwertiger Metalle /

Thesis (doctoral)--Kgl. Ludwig-Maximilians- Universitat zu Munchen, 1907.

Uber das Isostilben und die Bromderivate des Stilbens /

Thesis (doctoral)--Universitat Leipzig, 1900.

Die Kobaltdoppelnitrite und ihre beziehungen zu den Kobaltaminen und den Kobaltdoppelcyaniden /

Thesis (doctoral)--Friedrich-Wilhelms-Universitat zu Berlin, 1898.

Developing of Germyldesulonylation and Thiodesulfonylation Reactions for the Synthesis of Novel Nucleoside Analogues. Efficient Synthesis of Novel (α-Fluoro)vinyl Sulfides

S-adenosyl-L-homocysteine (AdoHcy) hydrolase effects hydrolytic cleavage of AdoHcy to produce both adenosine and L-homocysteine and is a feedback inhibitor of S-adenosyl- L-methionine (SAM). Nucleoside analogues bearing an alkenyl or fluoroalkenyl chain between sulfur and C5' utilizing Negishi coupling reactions were synthesized. Palladium-catalyzed cross-coupling between the 5'-deoxy-5'-(iodomethylene) nucleosides and alkylzinc bromides gives analogues with the alkenyl unit. Palladium-catalyzed selective monoalkylation of 5'-(bromofluoromethylene)-5'-deoxy-adenosine with alkylzinc bromide afford adenosylhomocysteine analogues with a 6'-(fluoro)vinyl motif. The vinylic adenine nucleosides produced time-dependent inactivation of the S-adenosyl-L-homocysteine hydrolases. Stannydesulfonylation reaction is a critical step in the synthesis of E-fluorovinyl cytidine (Tezacitabine) a ribonucleoside reductase inhibitor with a potent anticancer activity. The synthesis involves the removal of the sulfonyl group by a radical-mediated stannyldesulfonylation reaction using tributyltin hydride. In order to eliminate the toxicity of tin, I developed a radical-mediated germyldesulonylation utilizing less toxic germane hydrides. Treatment of the protected (E)-5'-deoxy-5'-[(p-toluenesulfonyl)-methylene]uridine and adenosine derivatives with tributyl- or triphenylgermane hydride effected radical-mediated germyldesulfonylations to give 5'-(tributyl- or triphenylgermyl)methylene-5'-deoxynucleoside derivatives as single (E)-isomers. Analogous treatment of 2'-deoxy-2'-[(phenylsulfonyl)methylene]uridine with Ph3GeH afforded the corresponding vinyl triphenylgermane product. Stereoselective halodegermylation of the (E)-5'-(tributylgermyl)-methylene-5'-deoxy nucleosides with NIS or NBS provided the Wittig-type (E)-5'-deoxy-5'-(halomethylene) nucleosides quantitatively. Radical-mediated thiodesulfonylation of the readily available vinyl and (α-fluoro) vinyl sulfones with aryl thiols in organic or aqueous medium to provide a bench and environmentally friendly protocol to access (α-fluoro)vinyl sulfides were developed. Methylation of the vinyl or (α-fluoro)vinyl phenyl sulfide gave access to the corresponding vinyl or (α-fluoro)vinyl sulfonium salts. These sulfonium ions were tested as possible methyl group donors during reactions with thiols, phenols or amino groups which are commonly present in natural amino acids.

Additions stéréosélectives sur des imines : du développement d'un auxiliaire à la catalyse asymétrique

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Total synthesis of furospongolide and related furanolipid analogues as potential anti-tumour agents

This thesis details the design, development and execution of innovative methodology in the total synthesis of the terpene-derived marine natural product, furospongolide. It also outlines the synthetic routes used to prepare a novel range of furanolipids derivatives and subsequent evaluation of their potential as antitumour agents. The first chapter is a review of the literature describing efforts undertaken towards the synthesis of biologically active furanosesterterpenoid marine natural products. A brief discussion on the sources and biological activity exhibited by furan natural products is also provided. In addition, a concise account of the role of hypoxia in cancer, and the increasing interest in HIF-1 inhibition as a target for chemotherapeutics is examined. The second chapter discusses the concise synthesis of the marine HIF-1 inhibitor furospongolide, which was achieved in five linear steps from (E,E)-farnesyl acetate. The synthetic strategy features a selective oxidation reaction, a Schlosser sp3-sp3 cross-coupling, a Wittig cross-coupling and an elaborate one-pot selective reduction, lactonisation and isomerization reaction to install the butenolide ring. The structure-activity relationship of furospongolide was also investigated. This involved the design and synthesis of a library of structurally modified analogues sharing the same C1-C13 subunit. This was achieved by exploiting the brevity and high level of convergence of our synthetic route together with the readily amenable structure of our target molecule. Exploiting the Schlosser cross-coupling allowed for replacement of furan with other heterocycles in the preparation of various furanolipid and thiophenolipid derivatives. The employment of reductive amination and Wittig chemistry further added to our novel library of structural derivatives. The third chapter discusses the results obtained from the NCI from biological evaluation From a collection of 28 novel compounds evaluated against the NCI-60 cancer cell array, six drug candidates were successfully selected for further biological evaluation on the basis of antitumour activity. COMPARE analysis revealed a strong correlation between some of our design analogues and the blockbuster anticancer agent tamoxifen, further supporting the potential of furanolipids in the treatment of breast cancer. The fourth chapter, details the full experimental procedures, including spectroscopic and analytical data for all the compounds prepared during this research.

Additions stéréosélectives sur des imines : du développement d'un auxiliaire à la catalyse asymétrique

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Dispositifs optoélectroniques à base de semi-conducteurs organiques en couches minces

Les petites molécules de type p à bandes interdites étroites sont de plus en plus perçues comme des remplaçantes possibles aux polymères semi-conducteurs actuellement utilisés conjointement avec des dérivés de fullerènes de type n, dans les cellules photovoltaïques organiques (OPV). Par contre, ces petites molécules tendent à cristalliser facilement lors de leur application en couches minces et forment difficilement des films homogènes appropriés. Des dispositifs OPV de type hétérojonction de masse ont été réalisés en ajoutant différentes espèces de polymères semi-conducteurs ou isolants, agissant comme matrices permettant de rectifier les inhomogénéités des films actifs et d’augmenter les performances des cellules photovoltaïques. Des polymères aux masses molaires spécifiques ont été synthétisés par réaction de Wittig en contrôlant précisément les ratios molaires des monomères et de la base utilisée. L’effet de la variation des masses molaires en fonction des morphologies de films minces obtenus et des performances des diodes organiques électroluminescentes reliées, a également été étudié. La microscopie électronique en transmission (MET) ou à balayage (MEB) a été employée en complément de la microscopie à force atomique (AFM) pour suivre l’évolution de la morphologie des films organiques minces. Une nouvelle méthode rapide de préparation des films pour l’imagerie MET sur substrats de silicium est également présentée et comparée à d’autres méthodes d’extraction. Motivé par le prix élevé et la rareté des métaux utilisés dans les substrats d’oxyde d’indium dopé à l’étain (ITO), le développement d’une nouvelle méthode de recyclage eco-responsable des substrats utilisés dans ces études est également présenté.

Serviço Social Profissão com Risco

A intranquilidade sentida ao nível do contexto de trabalho ou do bem-estar emocional dos assistentes sociais traduz o facto destes profissionais se terem tornado no rosto mais próximo das políticas de controlo das desigualdades e da exclusão, resultantes de todo um conjunto de factores que leva ao aumento da insegurança nos quotidianos de vida da população socialmente mais vulnerável. Com este estudo, de natureza exploratória, pretendeu demonstrar-se que o crescimento das incertezas e da violência, que singularizam a sociedade do risco, está a produzir alterações na relação do assistente social com o seu exercício profissional. A relação circular que tradicionalmente suportava o relacionamento instituído entre o indivíduo, instituição e assistente social deu origem à sua triangulação, assumindo o profissional, uma função quer de mediador, quer de gestor de interesses. Esta mesma transformação na qualidade da relação criada entre o assistente social e o utente, gera um exercício profissional praticado em tensão face ao medo controlado, ou não, das reacções menos esperadas de quem manifesta descontentamento em relação às medidas apresentadas pelos assistentes sociais, por via das instituições onde trabalham. Tendo o Serviço Social, desde o seu passado histórico, desenvolvido uma relação de trabalho muito próxima com grupos de risco e/ou perigo, nunca foi considerada uma profissão de risco. Contudo, face aos níveis de insegurança que actualmente cromatizam o habitat do exercício profissional dos assistentes sociais, a sua actividade profissional começa a manifestar sintomas de transformação numa profissão com riscos.