A construção do pan-americanismo na revista Em Guarda: o olhar americano pela defesa das Américas (1941-1946)

Pós-graduação em História - FCLAS

A defesa do pan-americanismo nas páginas de Américas: (1949-1968)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A construção do pan-americanismo na revista em guarda: o olhar norte-americano pela defesa das Américas (1941-1946)

O presente artigo discorre sobre o período de divulgação da revista Em Guarda (1941-1946). No decorrer de sua publicação, os norte-americanos apareciam como modelo de sociedade (político, cultural e social), enquanto aos latino-americanos cabia o papel de fornecer matérias-primas para a fabricação de produtos voltados à guerra. Pretendo discutir as estratégias adotadas pelo mensário na construção do discurso de união interamericana sob a ótica dos Estados Unidos. Desse modo, surgem novas possibilidades para o estudo das relações entre Brasil- Estados Unidos, em particular do pan-americanismo.

The first Pan-Podocnemididae turtle egg from the Presidente Prudente Formation (Late Cretaceous, Bauru Group), Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O atletismo na mídia: análise dos XV Jogos Pan-Americanos

Este trabalho tem como objetivo Identificar a forma pela qual o atletismo é divulgado pela mídia impressa. Para tanto, foram coletadas reportagens referentes a esta modalidade esportiva na mídia impressa durante o período dos Jogos Pan-Americanos do Rio de Janeiro, em 2007. Mais especificamente, foram analisadas as reportagens referentes ao atletismo, do jornal “Folha de São Paulo”, coletadas 13 dias antes dos Jogos Pan-Americanos, durante os Jogos Pan-Americanos e 13 dias após o seu término. Com base na Análise de conteúdo de Bardin (1979), foram identificadas 6 categorias de análise, quais sejam: “Quadro de resultados/críticas”; “Análise crítica da competição”; “Expectativa de resultados” “Reportagens poliesportivas”; “Lesões” e “História de vida e incentivo”. Os resultados demonstraram que a mídia, por meio de suas reportagens, exerce influência no modo e na forma com que o leitor interpreta o atletismo, já que registra críticas aos atletas; cria rivalidades entre eles; gera expectativas por resultados positivos e enaltece os melhores atletas em detrimento dos menos conhecidos do público. Por meio dessa pesquisa constatamos particularidades da relação entre o atletismo e a mídia, as quais certamente influenciam no conhecimento que se tem acerca dessa modalidade esportiva.

Relation between the level of self-mutilation and the concentration of fecal metabolites of glucocorticoids in captive chimpanzees (Pan troglodytes)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Pan-Assay interference compounds (PAINS): warning signs in biochemical-pharmacological evaluations

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) gamma Activators and Pan-PPAR Partial Agonists

Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) gamma to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these ligands mean that selective modulators with improved clinical profiles are needed. We obtained a crystal structure of PPAR gamma ligand binding domain (LBD) and found that the ligand binding pocket (LBP) is occupied by bacterial medium chain fatty acids (MCFAs). We verified that MCFAs (C8-C10) bind the PPAR gamma LBD in vitro and showed that they are low-potency partial agonists that display assay-specific actions relative to TZDs; they act as very weak partial agonists in transfections with PPAR gamma LBD, stronger partial agonists with full length PPAR gamma and exhibit full blockade of PPAR gamma phosphorylation by cyclin-dependent kinase 5 (cdk5), linked to reversal of adipose tissue insulin resistance. MCFAs that bind PPAR gamma also antagonize TZD-dependent adipogenesis in vitro. X-ray structure B-factor analysis and molecular dynamics (MD) simulations suggest that MCFAs weakly stabilize C-terminal activation helix (H) 12 relative to TZDs and this effect is highly dependent on chain length. By contrast, MCFAs preferentially stabilize the H2-H3/beta-sheet region and the helix (H) 11-H12 loop relative to TZDs and we propose that MCFA assay-specific actions are linked to their unique binding mode and suggest that it may be possible to identify selective PPAR gamma modulators with useful clinical profiles among natural products.

Role of an indole-thiazolidine molecule PPAR pan-agonist and COX inhibitor on inflammation and microcirculatory damage in acute gastric lesions

The present study aimed to show the in vivo mechanisms of action of an indole-thiazolidine molecule peroxisome-proliferator activated receptor pan-agonist (PPAR pan) and cyclooxygenase (COX) inhibitor, LYSO-7, in an ethanol/HCl-induced (Et/HCl) gastric lesion model. Swiss male mice were treated with vehicle, LYSO-7 or Bezafibrate (p.o.) 1 hour before oral administration of Et/HCl (60%/0.03M). In another set of assays, animals were injected i.p. with an anti-granulocyte antibody, GW9962 or L-NG-nitroarginine methyl ester (L-NAME) before treatment. One hour after Et/HCl administration, neutrophils were quantified in the blood and bone marrow and the gastric microcirculatory network was studied in situ. The gastric tissue was used to quantify the percentage of damaged area, as well as myeloperoxidase (MPO), inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS) protein and PPARγ protein and gene expression. Acid secretion was evaluated by the pylorus ligation model. LYSO-7 or Bezafibrate treatment reduced the necrotic area. LYSO-7 treatment enhanced PPARγ gene and protein expression in the stomach, and impaired local neutrophil influx and stasis of the microcirculatory network caused by Et/HCl administration. The effect seemed to be due to PPARγ agonist activity, as the LYSO-7 effect was abolished in GW9962 pre-treated mice. The reversal of microcirculatory stasis, but not neutrophil influx, was mediated by nitric oxide (NO), as L-NAME pre-treatment abolished the LYSO-7-mediated reestablishment of microcirculatory blood flow. This effect may depend on enhanced eNOS protein expression in injured gastric tissue. The pH and concentration of H(+) in the stomach were not modified by LYSO-7 treatment. In addition, LYSO-7 may induce less toxicity, as 28 days of oral treatment did not induce weight loss, as detected in pioglitazone treated mice. Thus, we show that LYSO-7 may be an effective treatment for gastric lesions by controlling neutrophil influx and microcirculatory blood flow mediated by NO