Subclinical hypothyroidism and the risk of coronary heart disease and mortality.

CONTEXT: Data regarding the association between subclinical hypothyroidism and cardiovascular disease outcomes are conflicting among large prospective cohort studies. This might reflect differences in participants' age, sex, thyroid-stimulating hormone (TSH) levels, or preexisting cardiovascular disease. OBJECTIVE: To assess the risks of coronary heart disease (CHD) and total mortality for adults with subclinical hypothyroidism. DATA SOURCES AND STUDY SELECTION: The databases of MEDLINE and EMBASE (1950 to May 31, 2010) were searched without language restrictions for prospective cohort studies with baseline thyroid function and subsequent CHD events, CHD mortality, and total mortality. The reference lists of retrieved articles also were searched. DATA EXTRACTION: Individual data on 55,287 participants with 542,494 person-years of follow-up between 1972 and 2007 were supplied from 11 prospective cohorts in the United States, Europe, Australia, Brazil, and Japan. The risk of CHD events was examined in 25,977 participants from 7 cohorts with available data. Euthyroidism was defined as a TSH level of 0.50 to 4.49 mIU/L. Subclinical hypothyroidism was defined as a TSH level of 4.5 to 19.9 mIU/L with normal thyroxine concentrations. RESULTS: Among 55,287 adults, 3450 had subclinical hypothyroidism (6.2%) and 51,837 had euthyroidism. During follow-up, 9664 participants died (2168 of CHD), and 4470 participants had CHD events (among 7 studies). The risk of CHD events and CHD mortality increased with higher TSH concentrations. In age- and sex-adjusted analyses, the hazard ratio (HR) for CHD events was 1.00 (95% confidence interval [CI], 0.86-1.18) for a TSH level of 4.5 to 6.9 mIU/L (20.3 vs 20.3/1000 person-years for participants with euthyroidism), 1.17 (95% CI, 0.96-1.43) for a TSH level of 7.0 to 9.9 mIU/L (23.8/1000 person-years), and 1.89 (95% CI, 1.28-2.80) for a TSH level of 10 to 19.9 mIU/L (n = 70 events/235; 38.4/1000 person-years; P <.001 for trend). The corresponding HRs for CHD mortality were 1.09 (95% CI, 0.91-1.30; 5.3 vs 4.9/1000 person-years for participants with euthyroidism), 1.42 (95% CI, 1.03-1.95; 6.9/1000 person-years), and 1.58 (95% CI, 1.10-2.27, n = 28 deaths/333; 7.7/1000 person-years; P = .005 for trend). Total mortality was not increased among participants with subclinical hypothyroidism. Results were similar after further adjustment for traditional cardiovascular risk factors. Risks did not significantly differ by age, sex, or preexisting cardiovascular disease. CONCLUSIONS: Subclinical hypothyroidism is associated with an increased risk of CHD events and CHD mortality in those with higher TSH levels, particularly in those with a TSH concentration of 10 mIU/L or greater.

Imagerie cardiaque non invasive: apport spécifique en clinique des nouvelles modalités (I). Evaluation morphologique [Cardiac imaging: specific clinical role of newly developed non invasive techniques. Part 1: Morphological evaluation].

Echocardiography is the preferred initial test to assess cardiac morphology and ventricular function. Cardiac MRI enables an optimal visualisation of heart muscle without contrast injection, and precise measurement of the ventricular volumes and systolic function. It is therefore an ideal test for patients with poor echocardiographic windows or for the specific evaluation of right heart chambers. Heart CT also remarkably images heart muscle and precisely measures ventricular systolic function after intravenous injection of iodinated contrast. Coronary CT may also, in selected cases, avoid the need for diagnostic coronary angiography. Although very accurate, these imaging modalities are expensive and may be contra-indicated for a particular patient. Their use in clinical practice has to follow the accepted guidelines.

ABD e-News May 7, 2004

Weekly Newsletter

Lottery Action, January 5-25, 2004, Vol. 11, no. 1

Iowa Lottery Authority Retailer Information Newsletter

Le Roman de la Rose : [de Guillaume de Lorris et Jean de Meung] : traduction libre et en vers / par Ét. Huard (de l'Ile Bourbon)

[Le roman de la rose (français). 1835]

The occurrence of reptiles in Barn Owl diet in Europe

Capsule We present a review of the propensity to eat reptiles in the Barn Owl Tyto alba in Europe. Based on the analysis of 591 published studies reporting 3.07 million prey items identified in pellets, only 2402 reptiles (0.08%) were found. Reptiles were most often captured in southern parts of the European continent and on islands. A large proportion of the 1304 identified reptiles to the species level were nocturnal Gekkonidae (77.1%).

CUBN is a gene locus for albuminuria.

Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 × 10(-11)) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.

Metodologia del treball en neologia: criteris, materials i processos

L'Observatori de Neologia, dirigit per la Dra. M. Teresa Cabré, neix com a grup de recerca l'any 1988 a la Universitat de Barcelona i des de 1994 s'incorpora com a projecte a l'Institut Universitari de Lingüística Aplicada de la Universitat Pompeu Fabra. L'Observatori de Neologia analitza el fenomen de l'aparició de paraules noves o neologismes en l'ús, tant pel que fa al català com al castellà. Actualment compta amb una base de dades de més de 82.000 ocurrències per al català i de més de 60.000 ocurrències per al castellà procedents de textos escrits i orals de mitjans de comunicació.Aquest volum recull la metodologia establerta des de l’inici del projecte pels membres fundadors de l’Observatori de Neologia - tot i que revisada i actualitzada al llarg dels anys. Aquesta metodologia guia tots els treballs de detecció, selecció, tractament i emmagatzemament de les dades que es duen a terme a l’Observatori.

In presenti libro continentur, item ars dipthongandi Guarini Veronensis. Item compendiosus dialogus de arte punctandi. Item tractatus utilis de accentu ([Reprod.]) / [Johannes de Lapide]

Collection : French books before 1601 ; 267.8

De situ orbis. [Christophori Nigri carmen ad Joannem Franciscum Dandalum de miseria vitae saecularis] ([Reprod.]) / [e graeco traducto Gregorio Typhernale, ac Guarino Veronense interpretibus] ; [Antonii Mancinelli praefatio] ; [Joannis Andreae epistola dedicatoria]

[Géographie (latin). 1510]

De situ orbis. Christophori Nigri Carmen ad Joannem Franciscum Dandulum de miseria vitae saecularis ([Reprod.]) / e graeco traducto Gregorio Typhernale, ac Guarino Veronense interpretibus ; [Antonii Mancinelli praefatio] ; [Joannis Andreae epistola dedicatoria]

[Géographie (latin). 1510]

De situ orbis ([Reprod.]) / [trad. de Guarino de Vérone]

[Géographie (latin). 1494]