Journal of Daniel Coker, : a descendant of Africa, from the time of leaving New York, in the ship Elizabeth, Capt. Sebor, on a voyage for Sherbro, in Africa, in company with three agents, and about ninety persons of colour. : The Rev. Samuel Bacon, John B. Bankson, Samuel S. Crozer. Agents. : With an appendix.

"Appendix to the Rev. D. Coker's Journal" (pages [41]-52) includes "Letter from Nathaniel Peck to his mother in Baltimore".

Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins

The interferon (IFN) response is the first line of defense against viral infections, and the majority of viruses have developed different strategies to counteract IFN responses in order to ensure their survival in an infected host. In this study, the abilities to inhibit IFN signaling of two closely related West Nile viruses, the New York 99 strain (NY99) and Kunjin virus (KUN), strain MRM61C, were analyzed using reporter plasmid assays, as well as immunofluorescence and Western blot analyses. We have demonstrated that infections with both NY99 and KUN, as well as transient or stable transfections with their replicon RNAs, inhibited the signaling of both alpha/beta IFN (IFN-alpha/beta) and gamma IFN (IFN-gamma) by blocking the phosphorylation of STAT1 and its translocation to the nucleus. In addition, the phosphorylation of STAT2 and its translocation to the nucleus were also blocked by KUN, NY99, and their replicons in response to treatment with IFN-alpha. IFN-alpha signaling and STAT2 translocation to the nucleus was inhibited when the KUN nonstructural proteins NS2A, NS2B, NS3, NS4A, and NS4B, but not NS1 and NS5, were expressed individually from the pcDNA3 vector. The results clearly demonstrate that both NY99 and KUN inhibit IFN signaling by preventing STAT1 and STAT2 phosphorylation and identify nonstructural proteins. responsible for this inhibition.

A Viking in New York : The Kensington Rune Stone at the 1964–1965 World’s Fair

A second-season makeover at the 1964-1965 New York World's Fair. Hoping that "an interesting controversy" would revive the state of Minnesota's failing pavilion, Minnesota adds a large fiberglass Viking, longboat-styled snack bars, and the contested Kensington Runestone itself to its 'Brainpower Builds Profits' exhibit. [abstract adapted from Minnesota History 63/1]

Gillette's map of Oneida Co., New York : from actual surveys /

County cadastral wall map showing towns (townships), numbered town survey divisions, irregular rural property tracts, rural buildings, and rural householders' names.

Map of the business portion of New York City below Madison Square : 1870.

General street map showing wards, piers, pier numbers, and streetcar lines.

Map of the business portion of New York City below Madison Square : 1870.

General street map showing wards, piers, pier numbers, and streetcar lines.

Correlation between urban form and PM2.5 concentration — Evidence from the New York metropolitan Area and Shanghai city

With the development of the economy and society, air pollution has posed a huge threat to public health around the world, especially to people who live in urban areas. Typically, urban development patterns can be roughly divided into compact cities and urban sprawl. In recent years, the relationship between urban form and air quality (especially PM2.5) is gaining more and more attention from urban planners, environmentalists, and governments. This study is focusing on The New York metropolitan area and Shanghai city, which are both megacities but with different urban spatial forms. For both study areas,there are five main variables to measure the urban form metrics, naming Population Density, Artificial Land Area Per Ten Thousand People, Road Density, Green Land Area Ratio and Artificial Land Area Ratio. In addition, considering the impact of economic activities and public transportation, GDP per capita, Number of bus stop and Number of subway station are used as control variables. Based on the results of regression, a megacity like the New York metropolitan area with urban sprawl shows a low spatial correlation on PM2.5 concentration. Meanwhile, almost all the spatial form indicators effect on PM2.5 concentration is not significant. However, a compact megacity like Shanghai shows a diametrically opposite result. Urban form, especially population density, has a strong relationship with PM2.5 concentration. It can be predicted that a reduction in population density would lead to significant improvements on decrease the PM2.5 concentration in Shanghai. Meanwhile, increasing the ratio of green land and construction area per capita will get a positive influence on reducing PM2.5 concentration as well. Road density is not a significant factor for a megacity in both two urban forms. The way and type of energy used by vehicles on megacities maybe more critical.

John Waldridge, The Leaven of the Ancients: Suhrawardi and the Heritage of the Greeks, SUNY Series in Islam (Albany: State University of New York Press, 1999). Pp. 323

In the Leaven of the Ancients, John Walbridge studies the appropriation of non–Peripatetic philosophical ideas by an anti–Aristotelian Islamic philosopher, Shihab al-Din al-Suhrawardi (d. 1191). He proposes a comprehensive explanation of the origin of Suhrawardi's philosophical system, a revival of the “wisdom of the Ancients” and its philosophical affiliations “grounded” in Greek philosophy (p. xiii). Walbridge attempts to uncover the reasons for Suhrawardi's rejection of the prevailing neo–Aristotelian synthesis in Islamic philosophy, Suhrawardi's knowledge and understanding of non–Aristotelian Greek philosophy, the ancient philosophers Suhrawardi was attempting to follow, the relationship between Suhrawardi's specific philosophical teachings (logic, ontology, physics, and metaphysics), and his understanding of non–Aristotelian ancient philosophy and the relationship between Suhrawardi's system and the major Greek philosophers, schools, and traditions—in particular the Presocratics, Plato, and the Stoics (p. 8). Copyright © 2003 Cambridge University Press

(Book review) Neuropsychotherapy and Community Integration: Brain Illness, Emotions, and Behavior. T. Judd. 1999. New York: Kluwer Academic/Plenum Publishers

As individuals gain expertise in a chosen field they can begin to conceptualize how what they know can be applied more broadly, to new populations and situations, or to increase desirable outcomes. Judd's book does just this. It takes our current understanding of the etiology, course, and sequelae of brain injuries, combines this with established psychotherapy and rehabilitation techniques, and expands these into a cogent model of what Judd calls “neuropsychotherapy.” Simply put, neuropsychotherapy attempts to address the cognitive, emotional and behavioral changes in brain-injured persons, changes that may go undiagnosed, misdiagnosed, or untreated.

DNA vaccine coding for the full-length infectious Kunjin virus RNA protects mice against the New York strain of West Nile virus

A plasmid DNA directing transcription of the infectious full-length RNA genome of Kunjin (KUN) virus in vivo from a mammalian expression promoter was used to vaccinate mice intramuscularly. The KUN viral cDNA encoded in the plasmid contained the mutation in the NS1 protein (Pro-250 to Leu) previously shown to attenuate KUN virus in weanling mice. KUN virus was isolated from the blood of immunized mice 3-4 days after DNA inoculation, demonstrating that infectious RNA was being transcribed in vivo; however, no symptoms of virus-induced disease were observed. By 19 days postimmunization, neutralizing antibody was detected in the serum of immunized animals. On challenge with lethal doses of the virulent New York strain of West Nile (WN) or wild-type KUN virus intracerebrally or intraperitoneally, mice immunized with as little as 0.1-1 mug of KUN plasmid DNA were solidly protected against disease. This finding correlated with neutralization data in vitro showing that serum from KUN DNA-immunized mice neutralized KUN and WN,viruses with similar efficiencies. The results demonstrate that delivery of an attenuated but replicating KUN virus via a plasmid DNA vector may provide an effective vaccination strategy against virulent strains of WN virus.

Maybelline New York, how to grow in Portugal?

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA – School of Business and Economics