Política de incentivos fiscais do Estado do Pará: uma abordagem neo-institucional e neo-schumpeterina

Este estudo avalia os impactos da implantação da política de incentivo fiscal do Governo do Estado do Pará sob a ótica neoinstitucional e neo-schumpeteriana. As externalidades dinâmicas compreendem um dos fundamentos dessas teorias para a análise do desenvolvimento econômico regional. A Nova Economia Institucional contempla de forma abrangente as instituições e suas transações, considerando a transação e todas as suas concatenações como ponto ótimo das instituições. A transação é avaliada mediante os “custos de transação”, dela decorrentes. Dessa forma analisa-se como um arranjo institucional, que permita a redução de custos inerentes às transações, pode incentivar empresas que promovam a geração de renda e emprego, bem como transformar a estrutura produtiva local. Insere-se de forma intrínseca a abordagem neo-schumpeteriana como fundamento das transformações provenientes nas empresas de modo a reduzir os custos de produção e transação, elevando a produção, a produtividade e a competitividade no mercado interno e externo.

Neo-liberalismo, educação e racionalização: a criação da Escola Livre de Sociologia e Política como prática política da grande indústria paulista nos anos 30.

Na efrevescência político-social que marcou as décadas de 1920 e 1930 no Brasil, quatro grandes temas ganhavam destaque e apareciam como bandeira comum à maioria dos atores em luta: industrialização, revolução, racionalização e educação. Em São Paulo, em meio as lutas pela universalização de uma vontade particular, o tema da educação ganha cores mais vivas, seja como lugar previlegiado do confronto político, seja, ao contrário como elemento aglutinador de grupos com interesses divergentes - como se pode observar quando do fortalecimento da bandeira da união em torno dos interesses paulistas. Bandeira essa que chega a transformar-se em forte mistica a partir do Movimento Constitucionalista de 1932: somente São Paulo seria capaz de fornecer homens suficientemente competentes para compor a elite dirigente do Brasil, um pais que passava por um período de grave crise provocada, principalmente, pela inexistência de uma sólida estrutura educacional moderna que fosse capaz de reeducar as massas e formar técnicos competentes para administar as coisas públicas. Com o fim do Movimento de 32, que havia sustentado uma aliança de diferentes grupos paulistas, entre eles o grupo político do jornal O Estado de São Paulo, principal responsável pelo projeto de criação da Universidade de São Paulo em 1934, e o núcleo de empresários representados pela FIESP (Federação das Indústrias do Estado de São Paulo) -, as práticas políticas particulares são retomadas. Em 1933, os empresários tomam a dianteira criando a Escola Livre de Sociologia e política, que aparece como um dos mais importantes atos políticosda grande indústria no Brasil. No discurso de inauguração, Roberto Simonsen, presidente da FIESP, admitindo a necessidade de reformulação do velho liberalismo ortodoxo e defendendo um Estado neo-liberal, indica a prática de largos horizontes com a qual essa escola deveria estar comprometida: a instituição de verdades científicas sobre a realidade brasileira, capazes de proporcionar os instrumentos necessários para garantir a correta ação de um Estado normatizador da sociedade segundo a vontade da grande indústria.

Contribuições a elucidação da estrutura, origem e evolução de neo-sistemas cromossômicos de determinação sexual em gafanhotos utilizando como modelo espécies dos gêneros Chlorus, Dichromatos e Eurotettix (Melanoplinae; Acrididae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Tecnologia da informação, discurso e poder: análise de domínio a partir do conceito de exclusão digital na perspectiva da teoria centro-periferia

Pós-graduação em Ciência da Informação - FFC

Neo-sex chromosomes of Ronderosia bergi: insight into the evolution of sex chromosomes in grasshoppers

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A Vale em Moçambique: uma etnografia das relações entre brasileiros e moçambicanos no cotidiano dos megaprojetos

Pós-graduação em Ciências Sociais - FCLAR

A NEO-KALECKIAN MODEL OF PROFIT SHARING, CAPACITY UTILIZATION AND ECONOMIC GROWTH

This paper sets forth a Neo-Kaleckian model of capacity utilization and growth with distribution featuring a profit-sharing arrangement. While a given proportion of firms compensate workers with only a base wage, the remaining proportion do so with a base wage and a share of profits. Consistent with the empirical evidence, workers hired by profit-sharing firms have a higher productivity than their counterparts in base-wage firms. While a higher profit-sharing coefficient raises capacity utilization and growth irrespective of the distribution of compensation strategies across firms, a higher frequency of profit-sharing firms does likewise only if the profit-sharing coefficient is sufficiently high.

Impact of treatment characteristics on response of different breast cancer phenotypes: pooled analysis of the German neo-adjuvant chemotherapy trials

Pathological complete response (pCR) to neoadjuvant treatment correlates with outcome in breast cancer. We determined whether characteristics of neoadjuvant therapy are associated with pCR. We used multi-level models, which accounted for heterogeneity in pCR across trials and trial arms, to analyze individual patient data from 3332 women included in 7 German neoadjuvant trials with uniform protocols. PCR was associated with an increase in number of chemotherapy cycles (odds ratio [OR] 1.2 for every two additional cycles; P = 0.009), with higher cumulative anthracycline doses (OR 1.6; P = 0.002), higher cumulative taxane doses (OR 1.6; P = 0.009), and with capecitabine containing regimens (OR 1.62; P = 0.022). Association of pCR with increase in number of cycles appeared more pronounced in hormone receptor (HR)-positive tumors (OR 1.35) than in HR-negative tumors (OR 1.04; P for interaction = 0.046). Effect of anthracycline dose was particularly pronounced in HER2-negative tumors (OR 1.61), compared to HER2-positive tumors (OR 0.83; P for interaction = 0.14). Simultaneous trastuzumab treatment in HER2-positive tumors increased odds of pCR 3.2-fold (P < 0.001). No association of pCR and number of trastuzumab cycles was found (OR 1.20, P = 0.39). Dosing characteristics appear important for successful treatment of breast cancer. Longer treatment, higher cumulative doses of anthracyclines and taxanes, and the addition of capecitabine and trastuzumab are associated with better response. Tailoring according to breast cancer phenotype might be possible: longer treatment in HR-positive tumors, higher cumulative anthracycline doses for HER2-negative tumors, shorter treatment at higher cumulative doses for triple-negative tumors, and limited number of preoperative trastuzumab cycles in HER2-positive tumors.

Improved neo-endothelialization of small diameter ePTFEgrafts with titanium coating

BACKGROUND: Patency of small synthetic bypass grafts is inferior compared to autologous grafts for revascularization procedures. Titanium coating of foreign surfaces has shown to decrease thrombogenicity, enhance biocompatibility and promote adhesion of endothelial cells. The aim of this study was to test the effect of titanium coating of small diameter ePTFE grafts on short term patency, neo-endothelialization and neointimal proliferation. METHODS: Bilateral carotid graft interposition was performed in 5 pigs with uncoated (n=5) and titanium-coated (n=5) ePTFE grafts (internal diameter=4 mm, length=5 cm), thus each pig served as its own control. At the end of the study (30 +/- 3 days), patency and stenosis severity was assessed by carotid angiography. Animals were sacrificed and grafts were excised for histology and scanning electron microscopy. Morphometry of histologic sections was carried out to determine neointimal proliferation and percentage of neo-endothelial coverage. RESULTS: Patency rate was 80% for uncoated and titanium-coated grafts. Quantitative angiography did not show any significant difference in lumen size between two groups. Morphometry revealed a significantly higher cellular coverage with CD31 positive endothelial cells for titanium-coated (84 +/- 19%) than uncoated grafts (48 +/- 26%, p<0.001). There was a non significant trend (p=0.112) towards increased neointimal proliferation in titanium-coated (94 +/- 61 micron2/micron) compared to uncoated grafts (60 +/- 57 micron2/micron). CONCLUSIONS: Patency rate in uncoated and titanium-coated ePTFE grafts is similar at one month. However, titanium coated grafts show a significant improvement in neo-endothelialization compared to uncoated grafts.

Multicenter trial of neo-adjuvant chemotherapy followed by extrapleural pneumonectomy in malignant pleural mesothelioma

BACKGROUND: The aim of this multicenter trial was to prospectively evaluate neo-adjuvant chemotherapy followed by extrapleural pneumonectomy (EPP) and radiotherapy, including quality of life as outcome. PATIENTS AND METHODS: Eligible patients had malignant pleural mesothelioma of all histological types, World Health Organization performance status of zero to two and clinical stage T1-T3, N0-2, M0 disease considered completely resectable. Neo-adjuvant chemotherapy consisted of three cycles of cisplatin and gemcitabine followed by EPP. Postoperative radiotherapy was considered for all patients. RESULTS: In all, 58 of 61 patients completed three cycles of neo-adjuvant chemotherapy. Forty-five patients (74%) underwent EPP and in 37 patients (61%) the resection was complete. Postoperative radiotherapy was initiated in 36 patients. The median survival of all patients was 19.8 months [95% confidence interval (CI) 14.6-24.5]. For the 45 patients undergoing EPP, the median survival was 23 months (95% CI 16.6-32.9). Psychological distress showed minor variations over time with distress above the cut-off score indicating no morbidity with 82% (N = 36) at baseline and 76% (N = 26) at 3 months after surgery (P = 0.5). CONCLUSIONS: The observed rate of operability is promising. A median survival of 23 months for patients undergoing EPP compares favourably with the survival reported from single center studies of upfront surgery. This approach was not associated with an increase in psychological distress.

Detection of apoptosis in vivo using antibodies against caspase-induced neo-epitopes

Cell death induction by apoptosis is an important process in the maintenance of tissue homeostasis as well as tissue destruction during various pathological processes. Consequently, detection of apoptotic cells in situ represents an important technique to assess the extent and impact of cell death in the respective tissue. While scoring of apoptosis by histological assessment of apoptotic cells is still a widely used method, it is likely biased by sensitivity problems and observed-based variations. The availability of caspase-mediated neo-epitope-specific antibodies offers new tools for the detection of apoptosis in situ. Here, we discuss the use of immunohistochemical detection of cleaved caspase 3 and lamin A for the assessment of apoptotic cells in paraffin-embedded liver tissue. Furthermore, we evaluate the effect of tissue pretreatment and antigen retrieval on the sensitivity of apoptosis detection, background staining and maintenance of tissue morphology.