Hādhā Sharḥ al-Raḥbīyah / lil-Imām al-ʻĀlim al-ʻAllāmah ... al-Shaykh Jalāl al-Dīn al-Suyūṭī : manuscript, 1697

Copy completed 13 Ramaḍān 1108 [April 5, 1697] in the hand of Muḥammad ibn Ibrāhīm al-Najāḥī al-Shāfiʻī.

Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb induction

Vertebrate limb induction is triggered in the lateral plate mesoderm (LPM) by a cascade of signaling events originating in the axial mesoderm. While it is known that Fgf, Wnt and retinoic acid (RA) signals are involved in this cascade, their precise regulatory hierarchy has not been determined in any species. tbx5 is the earliest gene expressed in the limb bud mesenchyme. Recently, another transcription factor, Prdm1, has been shown to be crucial for zebrafish forelimb development. Here, we show that Prdm1 is downstream of RA, Wnt2b and Tbx5 activity. We find that RA activity, but not Fgf signaling, is necessary for wnt2b expression. Fgf signaling is required for prdm1 expression in the fin bud, but is not necessary for the initiation of tbx5 expression. We propose a model in which RA signaling from the somitic mesoderm leads to activation of wnt2b expression in the intermediate mesoderm, which then signals to the LPM to trigger tbx5 expression. tbx5 is required for Fgf signaling in the limb bud leading to activation of prdm1 expression, which in turn is required for downstream activation of fgf10 expression.

Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes.

Vertebrate limbs develop in a temporal proximodistal sequence, with proximal regions specified and generated earlier than distal ones. Whereas considerable information is available on the mechanisms promoting limb growth, those involved in determining the proximodistal identity of limb parts remain largely unknown. We show here that retinoic acid (RA) is an upstream activator of the proximal determinant genes Meis1 and Meis2. RA promotes proximalization of limb cells and endogenous RA signaling is required to maintain the proximal Meis domain in the limb. RA synthesis and signaling range, which initially span the entire lateral plate mesoderm, become restricted to proximal limb domains by the apical ectodermal ridge (AER) activity following limb initiation. We identify fibroblast growth factor (FGF) as the main molecule responsible for this AER activity and propose a model integrating the role of FGF in limb cell proliferation, with a specific function in promoting distalization through inhibition of RA production and signaling.

Animales con pluma (el periodismo por dentro) Apuntes rápidos para una autobiografía píntoresca.

At head of title: Vincente A. Salaverri "Anton Martín Saavedra".

Ashmat Shomron : sipur hisṭori mi-yeme Aḥaz melekh Yehudah u-Feḳaḥ ben Remalyahu ṿe-Hosheʻa ben Elah malkhe Yiśraʾel.

Mode of access: Internet.

Physiologie de l'opéra, du carnaval du cancan et de la cachucha /

On cover: Physiologie du carnaval du cancan et de la cachucha; wanting in this copy.

Zemirot Yiśraʾel.

Hebrew words (transliterated); caption titles not transliterated.

Richard Coeur de Lion : opéra-comique en trois actes /

Mode of access: Internet.

Les deux avares : opéra bouffe en deux actes /

Mode of access: Internet.

Dimitri; opéra en 5 actes.

Mode of access: Internet.

Une nuit de Cléopâtre : opéra en 3 actes et 4 tableaux /

Mode of access: Internet.

Les Huguenots : opéra en cinq actes /

Mode of access: Internet.

Le prophète : opéra en cinq actes /

Mode of access: Internet.

Valse de l'opéra Faust de Gounod : trascrit pour le piano /

Mode of access: Internet.