Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein.

Cerebrovascular amyloid beta-protein (Abeta) deposition is a pathological feature of several related disorders including Alzheimer disease and hereditary cerebral hemorrhage with amyloidosis Dutch-type (HCHWA-D). HCHWA-D is caused by a point mutation in the gene that encodes the Abeta precursor and results in a Glu --> Gln substitution at position 22 of Abeta. In comparison to Alzheimer disease, the cerebrovascular Abeta deposition in HCHWA-D is generally more severe, often resulting in intracerebral hemorrhage when patients reach 50 years of age. We recently reported that Abeta(1-42), but not the shorter Abeta(1-40) induces pathologic responses in cultured human leptomeningeal smooth muscle cells including cellular degeneration that is accompanied by a marked increase in the levels of cellular Abeta precursor and soluble Abeta peptide. In the present study, we show that the HCHWA-D mutation converts the normally nonpathologic Abeta(1-40) into a highly pathologic form of the peptide for cultured human leptomeningeal smooth muscle cells. These findings suggest that these altered functional properties of HCHWA-D mutated Abeta may contribute to the early and often severe cerebrovascular pathology that is the hallmark of this disorder.

Pieter Bruegel the Elder’s Netherlandish Proverbs and Sixteenth Century Dutch Semiotics

"In 1559, Pieter Bruegel the Elder‘s depiction of {7f2015}Netherlandish Proverbs‖ illustrated his profound understanding of the Dutch love for proverbs, their contemporary values, and appreciation for moral lessons in art forms. Depicting gestures and poses that represented proverbial phrases enabled Bruegel‘s leap from didactic labels employed by other artists to his inscription-free success of {7f2015}Netherlandish Proverbs.‖ My examination reveals that Bruegel‘s employment of gestural imagery, indicating rhetorical phrases or proverbs, was reinforced by a history of scholarly curatorship for written proverb collections, humanist interest in proverbs, and use of Dutch vernacular to bolster protonational pride"

No evolution but revolution: The future of the Dutch terraced house

Dealing with the environmental problems is one of the biggest challenges within the field of architectural technology. Solutions to this problem are mostly exclusively sought in materials and computer technology. However, far more attention should be paid to humans and their role in this problem. This paper presents a small part of our bachelor thesis, which started as an investigation on the Dutch terraced house and through research ended as a study on the human behaviour and motivation. The first part of this paper, the evolution, is focussed on the traditional way of problem solving. The second part, the revolution, is focussed on human behaviour and motivation. These two studies put together lead to our conclusion: The only way to structurally solve our environmental problem is to revolutionize our way of building by involving the human interaction into our solution instead of forcing it out.

A new rodent from Dutch New Guinea [by] Wilfred H. Osgood.

v.31:no.1(1945)

The select works of Antony van Leeuwenhoek : containing his microscopical discoveries in many of the works of nature / translated from the Dutch and Latin editions published by the author, by Samuel Hoole.

2 (text)

The select works of Antony van Leeuwenhoek : containing his microscopical discoveries in many of the works of nature / translated from the Dutch and Latin editions published by the author, by Samuel Hoole.

1 (text)

The Dutch wish-list for a lighter regulatory touch from the EU. CEPS Commentary, 1 July 2013

The Dutch government set out the results of its review of EU competences on June 21st, under the slogan “European where necessary, national where possible”, claiming that the EU does not adequately respect the principles of subsidiarity and proportionality. It published a list of 54 points for corrective action, which Michael Emerson assesses in this new CEPS Commentary. The political significance of this initiative is heightened because it comes alongside the UK's ongoing review of EU competences, although unlike the British, the Dutch make no mention of secession, treaty changes or repatriation of competences.