980 resultados para Lancret, Nicolas, 1690-1743
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Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal
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Este ensayo examina los mecanismos de articulación política que se crearon entre el corregidor y los pueblos de indios que integraron el partido de Guatavita. Analiza la naturaleza y el monto del tributo que pagaron los indios y el manejo que el corregidor hizo de estos recursos. Estudia las cargas fiscales que se impusieron sobre la encomienda y los vínculos políticos que se desarrollaron entre encomenderos, corregidores y Estado colonial. La evidencia histórica que sirve de sustento a este trabajo proviene de la contabilidad que presentó el corregidor de Guatavita ante las autoridades coloniales a finales del siglo XVII.
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The Sarkozy presidency is shot through with paradox and contrast: between a well-elected president swiftly loathed by most voters; a ‘hyper-president’ who probably weakened the office; a talented party leader who lost effective control of his party; a right-wing president who was readily compared to Tony Blair; and an ambitious reformer who promised a clean break with the indecision of his two predecessors but whose record was more timid than his rhetoric. This article interprets Sarkozy’s record in the context of the presidential office, the specific circumstances of his presidency, and of the president’s own personality, skills and shortcomings.
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Introduction. Coitus in snakes may last up to 28 hours; however, the mechanisms involved are unknown. Aim. To evaluate the relevance of the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-phosphodiesterase type 5 (PDE5) system in snake corpus cavernosum reactivity. Methods. Hemipenes were removed from anesthetized South American rattlesnakes (Crotalus durissus terrificus) and studied by light and scanning electronic microscopy. Isolated Crotalus corpora cavernosa (CCC) were dissected from the non-spiny region of the hemipenises, and tissue reactivity was assessed in organ baths. Main Outcome Measures. Cumulative concentration-response curves were constructed for acetylcholine (ACh), sodium nitroprusside (SNP), 5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272), and tadalafil in CCC precontracted with phenylephrine. Relaxation induced by electrical field stimulation (EFS) was also done in the absence and presence of N omega nitro-L-arginine methyl ester (L-NAME; 100 mu M), 1H-[1, 2, 4] oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 10 mu M) and tetrodotoxin (TTX; 1 mu M). Results. The hemipenes consisted of two functionally concentric corpora cavernosa, one of them containing radiating bundles of smooth muscle fibers (confirmed by alpha-actin immunostaining). Endothelial and neural nitric oxide synthases were present in the endothelium and neural structures, respectively; whereas soluble guanylate cyclase and PDE5 were expressed in trabecular smooth muscle. ACh and SNP relaxed isolated CCC, with the relaxations being markedly reduced by L-NAME and ODQ, respectively. BAY 41-2272 and tadalafil caused sustained relaxations with potency (pEC(50)) values of 5.84 +/- 0.17 and 5.10 +/- 0.08 (N = 3-4), respectively. In precontracted CCC, EFS caused frequency-dependent relaxations that lasted three times longer than those in mammalian CC. Although these relaxations were almost abolished by either L-NAME or ODQ, they were unaffected by TTX. In contrast, EFS-induced relaxations in marmoset CC were abolished by TTX. Conclusions. Rattlesnake CC relaxation is mediated by the NO-cGMP-PDE5 pathway in a manner similar to mammals. The novel TTX-resistant Na channel identified here may be responsible for the slow response of smooth muscle following nerve stimulation and could explain the extraordinary duration of snake coitus. Capel RO, Monica FZ, Porto M, Barillas S, Muscara MN, Teixeira SA, Arruda AMM, Pissinatti, L, Pissinatti A, Schenka AA, Antunes E, Nahoum C, Cogo JC, de Oliveira MA, and De Nucci G. Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of corpus cavernosum from the South American rattlesnake Crotalus durissus terrificus. J Sex Med 2011;8:1616-1625.
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Este artigo tem por objetivo analisar aspectos históricos das questões políticas, ideológicas e conceituais que estiveram presentes nas discussões referentes à instrução nacional francesa no final do século XVIII, enfatizando as proposições de Condorcet, no Rapport de 1792, como sendo base desse tipo de debate durante o processo revolucionário na França. Privilegiamos, portanto, analisar as prerrogativas discursivas dessa proposta e o certame suscitado a partir dela, pois resultaram, até mesmo, em novas proposições, entre elas as de Romme, Robespierre, Lepelletier e Lakanal. Trata-se de uma abordagem que nos proporciona a compreensão da base moderna do debate sobre instrução pública que se configurou no século XIX. Essa concorrência de ideias entre os franceses se estabeleceu como o grande legado teórico para os sistemas modernos de ensino, inclusive o brasileiro. Depreendemos, ainda, que a instrução defendida na França estava permeada pelos ideais de razão, moral e cientificismo.
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[ES] En 1743 el ingeniero militar Miguel Marín diseñó un arsenal naval en Barcelona. En este artículo se estudia el contexto inmediato de este proyecto. Primeramente, la voluntad de trasladar la principal base naval mediterránea de Cartagena a la capital catalana. En segundo lugar, la relación centro-periferia y el papel del lobby catalán dentro del proceso.
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La tesi considera il discorso di Dakar sotto vari aspetti: tenendo conto delle analisi già pubblicate sull'argomento, pone particolare enfasi sul contesto enunciativo, sulle implicazioni del ruolo socio-politico dell'oratore, sull'utilizzo di determinate scelte linguistiche per trasmettere un messaggio non sempre in linea con quello apertamente dichiarato (e spesso contraddittorio). La tesi analizza inoltre in particolare il concetto di Africa nel discorso, nonché la visione della storia e della colonizzazione nel discorso (e le implicazioni colonialiste).