Functional and developmental studies of the peripheral arterial chemoreceptors in rat: effects of nicotine and possible relation to sudden infant death syndrome.

The drive on respiration mediated by the peripheral arterial chemoreceptors was assessed by the hyperoxic test in 3-day-old rat pups. They accounted for 22.5 +/- 8.8% during control conditions, but only for 6.9 +/- 10.0% after nicotine exposure, an effect counteracted by blockade of peripheral dopamine type 2 receptors (DA2Rs). Furthermore, nicotine reduced dopamine (DA) content and increased the expression of tyrosine hydroxylase (TH) in the carotid bodies, further suggesting that DA mediates the acute effect of nicotine on arterial chemoreceptor function. During postnatal development TH and DA2R mRNA levels in the carotid bodies decreased. Thus, nicotine from smoking may also interfere with the postnatal resetting of the oxygen sensitivity of the peripheral arterial chemoreceptors by increasing carotid body TH mRNA, as well as DA release in this period. Collectively these effects of nicotine on the peripheral arterial chemoreceptors may increase the vulnerability to hypoxic episodes and attenuate the protective chemoreflex response. These mechanisms may underlie the well-known relation between maternal smoking and sudden infant death syndrome.

Oversight of VA prosthetics and special-disabilities programs : hearing before the Committee on Veterans' Affairs, United States Senate, One Hundred First Congress, second session, June 7, 1990.

Mode of access: Internet.

Intellectual and educational status of the medical profession as represented in the United States army.

Mode of access: Internet.

Building a library collection on blindness and physical disabilities : basic materials and resources.

Mode of access: Internet.

Ancient ideals : a study of intellectual and spiritual growth from early times to the establishment of Christianity /

Mode of access: Internet.

Annual report of the Office of the Inspector General to the Governor and the General Assembly.

Description based on: FY89 (April 1988-June 1989).

Day camping for developmentally disabled and exceptional children /

On cover: Guidelines for establishing day camp programs.

Directory of department-related boards and commissions /

Identifies boards and commissions on which either the Director or the Director's designee serve or which have an interest in the Department's activities.

Exploring an increase in allegations, FY96-FY97 : a study by the Office of the Inspector General exploring the increase in allegations of abuse and neglect reported from the Department-operated mental health and developmental disability facilities /

"May 1999"--Letter of transmittal.

Illinois submission for ... under Public law 99-660 "The State Comprehensive Mental Health Services Plan Act of 1986" and Public law 601-639 "Mental Health Amendments of 1990" for adults with serious mental illness.

Description based on: Sept. 30,1991.

Our children deserve the best : a guide to networking in mental health and human services for children and adolescents /

"June, 1987."

Report to Governor James R. Thompson on the future of the mental health and developmentally disabled service system in Illinois ... /

"September 16, 1983."

State of care report to the Governor and the General Assembly /

"Annual report by the Office of the Inspector General to the Governor and the General Assembly is required by Public Act 85-223, allegations of abuse and neglect within the Department."

State of Illinois plan for the treatment and prevention of alcoholism and alcohol abuse for Illinois fiscal years '78-'80.

Cover title varies slightly.

Status report to the Governor and the General Assembly pursuant to Public Act 86-922, Federal Omnibus Budget Reconciliation Act of 1987.

Description based on: January 1989 - January 1990; title from cover.