The trial of Charles Random de Berenger, Sir Thomas Cochrane, commonly called Lord Cochrane, the Hon. Andrew Cochrane Johnstone, Richard Gathorne Butt, Ralph Sandom, Alexander M'Rae, John Peter Holloway and Henry Lyte for a conspiracy : in the court of King's Bench, Guildhall, on Wednesday the 8th and Thursday the 9th of June, 1814 ... /

Mode of access: Internet.

The substance of the speech of the Marquis Wellesley on the 31st January, 1812, in the House of Lords, on the motion of Earl Fitzwilliam, respecting the present state of Ireland.

NUC pre-1956

A description of the pictures, statues, busto's, basso-relievo's, and other curiosities at the Earl of Pembroke's house at Wilton /

Signatures: [A]⁴(-[A]1) B-P⁴ Q⁴(-Q4).

Miscellaneous state papers : from 1501-1726 ...

Mode of access: Internet.

Porcupine's works : containing various writings and selections, exhibiting a faithful picture of the United States of America; of their governments, laws, politics and resources; of the characters of their presidents, governors, legislators, magistrates, and military men; and of the customs, manners, morals, religion, virtues and vices of the people : comprising also a complete series of historical documents and remarks, from the end of the war, in 1783, to the election of the President, in March, 1801 /

continued: ... XII. Historical documents and remarks (from December, 1799 to March, 1801) ; Trial of Cooper ; Emigration Society ; Washington's death ; Proceedings in Congress during the session which began December, 1799 ; Board of Commissioners ; Defence of the Quakers of Pennsylvania ; Farewell advertisement ; Prison eclogue ; Republican morality ; Jefferson's election ; Adam's public conduct ; Jefferson's character ; Convention concluded between America and France, in 1800 ; Proceedings in Congress during the session which ended in March, 1801 ; Index.

The life of Thomas, Lord Cochrane, tenth Earl of Dundonald; completing "The autobiography of a seaman."

Mode of access: Internet.

The dramatic writings of Richard Edwards,

Mode of access: Internet.

Selections from Addison and Steele,

Mode of access: Internet.

The Earl of Mayo,

Mode of access: Internet.

The first parte of the eyghth liberall science : entituled, ars adulandi, the arte of flatterie ... /

STC (2nd ed.) gives W. Howe as actual printer.

Concord lectures on philosophy, comprising outlines of all the lectures at the Concord summer school of philosophy in 1882, with an historical sketch;

References: Blanck. Bibl. Amer. lit. 129.

Aprataxin, a novel protein that protects against genotoxic stress

Ataxia-oculomotor apraxia (AOA1) is a neurological disorder with symptoms that overlap those of ataxia-telangiectasia, a syndrome characterized by abnormal responses to double-strand DNA breaks and genome instability. The gene mutated in AOA1, APTX, is predicted to code for a protein called aprataxin that contains domains of homology with proteins involved in DNA damage signalling and repair. We demonstrate that aprataxin is a nuclear protein, present in both the nucleoplasm and the nucleolus. Mutations in the APTX gene destabilize the aprataxin protein, and fusion constructs of enhanced green fluorescent protein and aprataxin, representing deletions of putative functional domains, generate highly unstable products. Cells from AOA1 patients are characterized by enhanced sensitivity to agents that cause single-strand breaks in DNA but there is no evidence for a gross defect in single-strand break repair. Sensitivity to hydrogen peroxide and the resulting genome instability are corrected by transfection with full-length aprataxin cDNA. We also demonstrate that aprataxin interacts with the repair proteins XRCC1, PARP-1 and p53 and that it co-localizes with XRCC1 along charged particle tracks on chromatin. These results demonstrate that aprataxin influences the cellular response to genotoxic stress very likely by its capacity to interact with a number of proteins involved in DNA repair.

Preclinical Target Validation Using Patient-derived Cells.

The Structural Genomics Consortium (SGC) and its clinical, industry and disease-foundation partners are launching open-source preclinical translational medicine studies.