679 resultados para Herzog


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<p>Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 10(-7)) in SOX2OT and rs17030795 (P=5.84 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 10(<sup>-6</sup>)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.</p>

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<p>Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species' threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project - and avert - future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups - including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems - http://www.predicts.org.uk). We make site-level summary data available alongside this article. The full database will be publicly available in 2015.</p>

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<p>There are no European recommendations on issues specifically related to lung transplantation (LTX) in cystic fibrosis (CF). The main goal of this paper is to provide CF care team members with clinically relevant CF-specific information on all aspects of LTX, highlighting areas of consensus and controversy throughout Europe. Bilateral lung transplantation has been shown to be an important therapeutic option for end-stage CF pulmonary disease. Transplant function and patient survival after transplantation are better than in most other indications for this procedure. Attention though has to be paid to pretransplant morbidity, time for referral, evaluation, indication, and contraindication in children and in adults. This review makes extensive use of specific evidence in the field of lung transplantation in CF patients and addresses all issues of practical importance. The requirements of pre-, peri-, and postoperative management are discussed in detail including bridging to transplant and postoperative complications, immune suppression, chronic allograft dysfunction, infection, and malignancies being the most important. Among the contributors to this guiding information are 19 members of the ECORN-CF project and other experts. The document is endorsed by the European Cystic Fibrosis Society and sponsored by the Christiane Herzog Foundation.</p>

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Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project and avert future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems www.predicts.org.uk). We make site-level summary data available alongside this article. The full database will be publicly available in 2015.

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Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasminogen activator (t-PA) and u-Pa have been designed to direct the synthesis of new plasminogen activators.

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A cDNA library prepared from human liver was screened for -antitrypsin, a major constituent of plasma which functions as inhibitor of proteolytic enzyms. The library was screened using a 12-base-long synthetic oligodeoxyribonucleotide corresponding to a known DNA fragment of human -antitrypsin and by hybrid-selection of -antitrypsin mRNA.

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Afin de tenir compte de ces recommandations pour notre alimentation quotidienne, il faut adapter aussi bien les menus domestiques destins la famille que les menus des cantines sur les lieux de travail, et ceci de faon simultane. Ce but peut tre atteint sans modifier nos traditions alimentaires, ni mme notre approvisionnement.Le respect de ces directives permettra d'quilibrer rapidement notre alimentation et adapter notre consommation nos besoins rels.

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El propsito de esta disertacin es rescatar las interpretaciones de Tierra y Mar en lo que se refiere al surgimiento del Orden Internacional Moderno, con el objetivo de explicar la percepcin de los acontecimientos por parte de Carl Schmitt y su aporte filosfico-jurdico a la comprensin de la historia y teora de las Relaciones Internacionales. La particularidad de esta obra de Schmitt es su estilo profundo: la variedad y amplitud de temas que abarca, que contrasta con la brevedad del texto. El presente trabajo ha encontrado vacos en el estudio de Tierra y Mar, as como interpretaciones distintas a las propuestas por el autor, en lo concerniente al surgimiento del Orden Internacional Moderno. La originalidad de la obra de Schmitt consiste en proponer, en realidad, dos rdenes internacionales distintos que surgen en el mundo moderno.

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El presente estudio de caso es un anlisis sobre el conflicto entre Siria e Israel a partir de la disputa por los Altos del Goln, luego de la ocupacin por parte de Israel al finalizar la Guerra de los Seis Das. A diferencia de la mayora de los trabajos que se realizan sobre Medio Oriente, este trabajo busca diferenciarse de los estudios sobre el conflicto rabe-israel, enfocndose en el conflicto sirio-israel. Adicionalmente, se trata un tema poco comn como son las implicaciones que este conflicto ha tenido sobre la comunidad drusa siria, poblacin que qued en medio de las disputas por los Altos del Goln. Teniendo en cuenta lo anterior, se har un anlisis a partir del Inters Nacional que motiva tanto a Siria como a Israel y a la comunidad drusa que ah habita a seguir en la disputas por este territorio, que gracias a sus caractersticas geogrficas representa un punto estratgico en la regin.

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El texto pretende esbozar un modo de disposicin y exposicin del archivo visual basado en la nocin de montaje. El mtodo se esbozar a partir de algunos de los elementos del proceder metodolgico de Aby Warburg y Walter Benjamin. Las correspondencias que se han trazado entre las prcticas histricas de ambos autores, se aprovecharn para dar cuenta de un mtodo que comparten en cuanto al modo especial de entender las relaciones entre los elementos del archivo y las temporalidades que es posible establecer a partir de estas relaciones. Desde all, se sugiere la posibilidad de construir un montaje de imgenes, producidas en diferentes contextos de circulacin con el motivo iconogrfico de la lengua violentada, a travs del cual se alude a las relaciones entre memoria, violencia y silencio, y con el que se muestra que este procedimiento hace posible establecer correspondencias entre diferentes pocas de la violencia en Colombia.

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Se desarrollan las ventajas de un nuevo pensamiento para la teora pedaggica segn la educacin moral. En una primera parte, se traza un esbozo de la vinculacin de la interaccin pedaggica y la social, con el fin de hallar un concepto de subjetividad que permita comprender la dependencia entre la autonoma individual y la reciprocidad social. En una segunda parte, se introducen las categoras morales que estn ligadas entre s en el principio del mutuo reconocimiento. Por ltimo, en la tercera parte, se corrobora la exposicin terica con ayuda de las nuevas investigaciones psicolgicas sobre el desarrollo moral, extrayendo algunas consecuencias para la teora de la educacin moral.

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El artculo forma parte de un monogrfico dedicado a la hibridacin en las artes plsticas.- Resumen tomado parcialmente de la revista.