Tabulation of multiple responses

Although multiple-response questions are quite common in survey research, Stata’s official release does not provide much capability for an effective analysis of multiple-response variables. For example, in a study on drug addiction an interview question might be, “Which substances did you consume during the last four weeks?” The respondents just list all the drugs they took, if any; e.g., an answer could be “cannabis, cocaine, heroin” or “ecstasy, cannabis” or “none”, etc. Usually, the responses to such questions are stored as a set of variables and, therefore, cannot be easily tabulated. I will address this issue here and present a new module to compute one- and two-way tables of multiple responses. The module supports several types of data structure, provides significance tests, and offers various options to control the computation and display of the results. In addition, tools to create graphs of multiple-response distributions are presented.

Childhood sexual victimization: Risk factor for drug use and sexual risk behaviors

The purpose of this dissertation was to survey men in the Harris County Jail (HCJ) to establish a more valid estimate of childhood sexual abuse (CSA) prevalence in a jailed-based population; to assess whether inmates with a history of CSA were at greater risk for use of drugs and alcohol and engaging in high-risk sexual behaviors than those without histories of childhood sexual abuse. ^ The first study determined the prevalence of childhood sexual abuse among incarcerated males in a county jail. In this study, sixty-three percent of the subjects reported having been sexually abused. Sixty-one percent reported abuse pre-puberty and 10% reported abuse post puberty. In pre-puberty abuse the initiation of first abuse occurred at a mean age of 5.6 years (SD 5.096, range: 2–13 years). ^ The second study explored the association between inmates with histories of CSA as a risk factor for sexual risk behaviors. A history of sexual abuse did not appear to be associated with an elevated risk of sexual risk behaviors. ^ The third study explored a history of drug use and a history of CSA among the inmates. A chi-square test showed that the inmates who reported a history of CSA, was significantly greater for the following drugs: Marijuana (02), Crack (03), Heroin/Morphine (.03), Amphetamines/Speed (01), Downers/Barbiturates (.001), Methamphetamine/Crystal Meth (.001), Valium .02), LSD/Acid (.001), and Inhalants (.001), p < .05). Significance was not found in alcohol, tobacco, cocaine, Quaaludes and methadone. ^ The research from this study provides empirical data supporting previous research. The current data shows that incarcerated inmates have a high prevalence of childhood sexual abuse and drug use. Sexual victimization as a child does not appear to be associated with an elevated risk of unsafe sexual behaviors. However, men who used drugs were twice as likely to have engaged in unprotected sex with casual and regular partners, and rarely used condoms with paid sex. Although our study methods do not permit a causal explanation for this association, we believe it is of concern. Finally, data in this study shows that sexually abused children are likely candidates for adult criminal behavior. ^

Predictors of HIV testing among injection drug users

The current analysis examined the association of several demographic and behavioral variables with prior HIV testing within a population of injection drug users (IDUs) living in Harris County, Texas in 2005 (n=563). After completing the initial univariate analyses of all potential predictors, a multivariable model was created. This model was designed to guide future intervention efforts. Data used in this analysis were collected by the University of Texas School of Public Health in association with the Houston Department of Health and Human Services for the first IDU cycle of the National HIV Behavioral Surveillance System. About 76% of the IDUs reported previously being tested for HIV. Demographic variables that displayed a significant association with prior testing during the univariate analyses include age, race/ethnicity, birth outside the United States, education level, recent arrest, and current health insurance coverage. Several drug-related and sexual behaviors also demonstrated significant associations with prior testing, including age of first injection drug use, heroin use, methamphetamine use, source of needles or syringes, consistent use of new needles, recent visits to a shooting gallery or similar location, previous alcohol or drug treatment, condom use during their most recent sexual encounter, and having sexual partners who also used injection drugs. Additionally, the univariate analyses revealed that recent use of health or HIV prevention services was associated with previously testing for HIV. The final multivariable model included age, race/ethnicity, recent arrest, previous alcohol or drug treatment, and heroin use. ^

Risk factors for encephalitis and death from West Nile virus infection: An analysis of hospitalized cases in Houston, Texas from 2002--2008

We conducted a nested case-control study to determine the significant risk factors for developing encephalitis from West Nile virus (WNV) infection. The purpose of this research project was to expand the previously published Houston study of 2002–2004 patients to include data on Houston patients from four additional years (2005–2008) to determine if there were any differences in risk factors shown to be associated with developing the more severe outcomes of WNV infection, encephalitis and death, by having this larger sample size. A re-analysis of the risk factors for encephalitis and death was conducted on all of the patients from 2002–2008 and was the focus of this proposed research. This analysis allowed for the determination to be made that there are differences in the outcome in the risk factors for encephalitis and death with an increased sample size. Retrospective medical chart reviews were completed for the 265 confirmed WNV hospitalized patients; 153 patients had encephalitis (WNE), 112 had either viral syndrome with fever (WNF) or meningitis (WNM); a total of 22 patients died. Univariate logistic regression analyses on demographic, comorbidities, and social risk factors was conducted in a similar manner as in the previously conducted study to determine the risk factors for developing encephalitis from WNV. A multivariate model was developed by using model building strategies for the multivariate logistic regression analysis. The hypothesis of this study was that there would be additional risk factors shown to be significant with the increase in sample size of the dataset. This analysis with a greater sample size and increased power supports the hypothesis in that there were additional risk factors shown to be statistically associated with the more severe outcomes of WNV infection (WNE or death). Based on univariate logistic regression results, these data showed that even though age of 20–44 years was statistically significant as a protecting effect for developing WNE in the original study, the expanded sample lacked significance. This study showed a significant WNE risk factor to be chronic alcohol abuse, when it was not significant in the original analysis. Other WNE risk factors identified in this analysis that showed to be significant but were not significant in the original analysis were cancer not in remission > 5 years, history of stroke, and chronic renal disease. When comparing the two analyses with death as an outcome, two risk factors that were shown to be significant in the original analysis but not in the expanded dataset analysis were diabetes mellitus and immunosuppression. Three risk factors shown to be significant in this expanded analysis but were not significant in the original study were illicit drug use, heroin or opiate use, and injection drug use. However, with the multiple logistic regression models, the same independent risk factors for developing encephalitis of age and history of hypertension including drug induced hypertension were consistent in both studies.^

Prevalence and trends of substance abuse in Harris County, Texas, 1989 to 1991

In the late 1980s, Harris County, Texas began experiencing an escalation of drug-related activities. Various indicators used in this analysis tracked drug-related trends from 1989 to 1991 to determine patterns for comparison of local (Houston/Harris County, Texas) to national levels.^ An important indicator of the drug scenario was drug-related activities among youths, which increased during the period of this study. The Harris County Juvenile Probation Department showed that among arrests for drug-related activities, felonies increased from 25% in 1988 to 53% in 1991. With the rise in drug-related crimes, and substance abuse among the student body, school districts were forced to institute drug education programs in an effort to curtail such activities.^ Law enforcement agencies in the county saw increased demands for their services as a result of drug activities. Harris County Sheriffs Department reported a 32% plus increase in drug-related charges between 1986 and 1991. Houston Police Department reported an increase of 109% for the same period.^ Data from the Harris County Medical Examiner, the National Institute of Justice's Drug Use Forecasting System (Houston), and drug treatment facilities around Houston/Harris County, Texas indicated similar drug usage trends. Over a four-year period (1988-91), the drugs most frequently detected during blood and urine analyses were cocaine, followed by marijuana, heroin, LSD, and methamphetamines.^ From 1988 to 1991, most drug rehabilitation organizations experienced increased demands for their services by approximately 35%. Several other organizations experienced as much as a 70 percent increase. Males accounted for roughly 70% and females about 30% of persons seeking treatment. However, the number of females pursuing treatment increased, thereby reducing the gender gap.^ Blacks in Houston/Harris County were at higher risk for drug usage among the general population, but sought treatment more readily than other ethnic groups. Whites sought treatment in similar numbers as Blacks, but overall the risk appeared smaller because they made up a larger portion of the Houston/Harris County population.^ This analysis concluded that drug trends for the Houston/Harris County, Texas did not follow national trends, but showed patterns of its own. It was recommended that other communities carry out similar studies to determine drug use trends particular to their local. ^

Perfil clínico y social del paciente adicto hospitalizado

Objetivos: Determinar las características clínicas y morbilidad de los pacientes (pac.) adictos ingresados a un Servicio de Clínica Médica. Material y métodos: Estudio protocolizado, observacional, descriptivo y transversal. Criterio de inclusión: pac. adicto con consumo de sustancias ilícitas. Informe preliminar: Periodo: 24 meses. Datos analizados en Epi info 6.4 Resultados: Se incluyeron 40 pac. Prevalencia: 0.2/1000 egresos. El 82.5% eran hombres. Edad media: 31.5 años (DS±9.65). Permanencia media: 11 días (DS±13.98) vs 7.12 (DS±10.1) del Servicio (p=0.016). Consumían cocaína el 82.5% (IC95%67.22-92.66) marihuana el 77.5% (IC95% 61.65- 89.16), tolueno el 10% (IC95%2.79-23.66), floripondio y hachis el 2.5% (IC95% 0.06-13.16) cada uno. En el 2.5% la vía de administración era endovenosa y el 60% eran poliadictos. Solo el 10% recibió tratamiento para abandonar la adicción (100% tratamiento psicológico y 5.13% farmacológico). De clase social pobre el 75%. El 62.5% de los pac. estaban desocupados, tenían antecedentes judiciales el 10% y el 7.5% había estado en prisión. El 92.5% (IC95% 76.34-97.21) era heterosexual, 2.5% hombres que tenían sexo con hombres y bisexuales 5% (IC95% 0.61-16.92). Solo el 10% tenían secundaria completa. El 80% ingreso por Emergencias y por causa infecciosa el 45%. El 12.5% ingreso por complicaciones de la adicción. Las manifestaciones relacionadas con la adicción fueron: manifestaciones del sistema nervioso central: 12.5% (IC95%4.19-26.80); síndrome de abstinencia y temblor 7.5% cada uno y excitación psicomotriz, delirium, signo de foco neurológico y rigidez 5% cada uno. El 100% presentaba alguna comórbida; tabaquismo 80%, depresión 12.8% Y alcoholismo 57.5%, entre otras. Presentaban enfermedades de transmisión sexual 5 pac. (4 HIV, 2 VHC y 1 pediculus pubis). No hubo mortalidad hospitalaria. Conclusión: El paciente adicto internado se caracteriza por ser joven, pertenecer a un grupo social desprotegido, sin trabajo y sin educación, tener poliadicción, con alta carga de comórbidas y de internación, principalmente por complicaciones infecciosas.

El azar de la mujer rubia, de Manuel Vicent : Memorias de la transición entre la ficción, la prensa y la historia

En el siguiente trabajo me propongo analizar la novela escrita por Manuel Vicent El azar de la mujer rubia. El texto se nos presenta como una nueva mirada sobre la transición, esta vez estructurada desde un personaje femenino a partir del cual se trazan los hilos de la historia española desde la muerte de Franco hasta la actualidad. Sin embargo, la lectura de la obra revela que el personaje que se encuentra en primer plano no es otro que Adolfo Suárez y que el material que funciona como punto de partida es la propia obra periodística de Manuel Vicent. Puede pensarse entonces esta novela como un intento de salvar del olvido aquellos artículos periodísticos de un valor inestimable -por haber sido escritos en el momento en que los acontecimientos históricos se estaban desarrollando- pero también como una obra presentada como novedosa por develar la trama oculta de un triángulo amoroso que influyó directamente en la historia del país, con un personaje femenino que es, por primera vez,recuperado y transformado en heroína. El estudio se centrará entonces en la forma en que Vicent recupera aquellos textos periodísticos y en las operaciones de inclusión de los mismos en una narración que mezcla ficción con historia para regresar, una vez más, a uno de los momentos trascendentes de la historia reciente española

Una lectura de la Lisistrata de Aristófanes

El propósito de este trabajo es despertar el interés por la lectura de Aristófanes, concretamente de la Lisístrata, por los muchos datos que ofrece: históricos, sociales, políticos, míticos y religiosos. La protagonista de tal comedia es la primera heroína femenina del teatro aristofánico. La relación de la comedia antigua con la vida política es permanente, incesante: las mujeres atenienses, cansadas de la guerra contra los lacedemonios, deciden obtener la paz de una forma singular: absteniéndose de relaciones sexuales con sus esposos y, asimismo, de sus obligaciones familiares. La utopía cómica, el mundo al revés, se nos manifiesta de modo evidente.

El azar de la mujer rubia, de Manuel Vicent : memorias de la transición entre la ficción, la prensa y la historia

En el siguiente trabajo me propongo analizar la novela escrita por Manuel Vicent El azar de la mujer rubia. El texto se nos presenta como una nueva mirada sobre la transición, esta vez estructurada desde un personaje femenino a partir del cual se trazan los hilos de la historia española desde la muerte de Franco hasta la actualidad. Sin embargo, la lectura de la obra revela que el personaje que se encuentra en primer plano no es otro que Adolfo Suárez y que el material que funciona como punto de partida es la propia obra periodística de Manuel Vicent. Puede pensarse entonces esta novela como un intento de salvar del olvido aquellos artículos periodísticos de un valor inestimable -por haber sido escritos en el momento en que los acontecimientos históricos se estaban desarrollando- pero también como una obra presentada como novedosa por develar la trama oculta de un triángulo amoroso que influyó directamente en la historia del país, con un personaje femenino que es, por primera vez,recuperado y transformado en heroína. El estudio se centrará entonces en la forma en que Vicent recupera aquellos textos periodísticos y en las operaciones de inclusión de los mismos en una narración que mezcla ficción con historia para regresar, una vez más, a uno de los momentos trascendentes de la historia reciente española

El azar de la mujer rubia, de Manuel Vicent : Memorias de la transición entre la ficción, la prensa y la historia

En el siguiente trabajo me propongo analizar la novela escrita por Manuel Vicent El azar de la mujer rubia. El texto se nos presenta como una nueva mirada sobre la transición, esta vez estructurada desde un personaje femenino a partir del cual se trazan los hilos de la historia española desde la muerte de Franco hasta la actualidad. Sin embargo, la lectura de la obra revela que el personaje que se encuentra en primer plano no es otro que Adolfo Suárez y que el material que funciona como punto de partida es la propia obra periodística de Manuel Vicent. Puede pensarse entonces esta novela como un intento de salvar del olvido aquellos artículos periodísticos de un valor inestimable -por haber sido escritos en el momento en que los acontecimientos históricos se estaban desarrollando- pero también como una obra presentada como novedosa por develar la trama oculta de un triángulo amoroso que influyó directamente en la historia del país, con un personaje femenino que es, por primera vez,recuperado y transformado en heroína. El estudio se centrará entonces en la forma en que Vicent recupera aquellos textos periodísticos y en las operaciones de inclusión de los mismos en una narración que mezcla ficción con historia para regresar, una vez más, a uno de los momentos trascendentes de la historia reciente española

Una lectura de la Lisistrata de Aristófanes

El propósito de este trabajo es despertar el interés por la lectura de Aristófanes, concretamente de la Lisístrata, por los muchos datos que ofrece: históricos, sociales, políticos, míticos y religiosos. La protagonista de tal comedia es la primera heroína femenina del teatro aristofánico. La relación de la comedia antigua con la vida política es permanente, incesante: las mujeres atenienses, cansadas de la guerra contra los lacedemonios, deciden obtener la paz de una forma singular: absteniéndose de relaciones sexuales con sus esposos y, asimismo, de sus obligaciones familiares. La utopía cómica, el mundo al revés, se nos manifiesta de modo evidente.

Una lectura de la Lisistrata de Aristófanes

El propósito de este trabajo es despertar el interés por la lectura de Aristófanes, concretamente de la Lisístrata, por los muchos datos que ofrece: históricos, sociales, políticos, míticos y religiosos. La protagonista de tal comedia es la primera heroína femenina del teatro aristofánico. La relación de la comedia antigua con la vida política es permanente, incesante: las mujeres atenienses, cansadas de la guerra contra los lacedemonios, deciden obtener la paz de una forma singular: absteniéndose de relaciones sexuales con sus esposos y, asimismo, de sus obligaciones familiares. La utopía cómica, el mundo al revés, se nos manifiesta de modo evidente.

El azar de la mujer rubia, de Manuel Vicent : Memorias de la transición entre la ficción, la prensa y la historia

En el siguiente trabajo me propongo analizar la novela escrita por Manuel Vicent El azar de la mujer rubia. El texto se nos presenta como una nueva mirada sobre la transición, esta vez estructurada desde un personaje femenino a partir del cual se trazan los hilos de la historia española desde la muerte de Franco hasta la actualidad. Sin embargo, la lectura de la obra revela que el personaje que se encuentra en primer plano no es otro que Adolfo Suárez y que el material que funciona como punto de partida es la propia obra periodística de Manuel Vicent. Puede pensarse entonces esta novela como un intento de salvar del olvido aquellos artículos periodísticos de un valor inestimable -por haber sido escritos en el momento en que los acontecimientos históricos se estaban desarrollando- pero también como una obra presentada como novedosa por develar la trama oculta de un triángulo amoroso que influyó directamente en la historia del país, con un personaje femenino que es, por primera vez,recuperado y transformado en heroína. El estudio se centrará entonces en la forma en que Vicent recupera aquellos textos periodísticos y en las operaciones de inclusión de los mismos en una narración que mezcla ficción con historia para regresar, una vez más, a uno de los momentos trascendentes de la historia reciente española

Tabulation of multiple responses

Although multiple response questions are quite common in survey research, Stata's official release does not provide much possibility for an effective analysis of multiple response variables. For example, in a study on drug addiction an interview question might be, "Which substances did you consume during the last four weeks?" The respondents just list all the drugs they took if any, e.g., an answer could be "cannabis, cocaine, heroin" or "ecstasy, cannabis" or "none", etc. Usually, the responses to such questions are held as a set of variables and, therefore, cannot be easily tabulated. I will address this issue and present a new module to compute one- and two-way tables of multiple responses. The module supports several types of data structure, provides significance tests, and offers various options to control the computation and display of the results.

In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor

The nicotinic acetylcholine receptor (AChR) controls signal transmission between cells in the nervous system. Abused drugs such as cocaine inhibit this receptor. Transient kinetic investigations indicate that inhibitors decrease the channel-opening equilibrium constant [Hess, G. P. & Grewer, C. (1998) Methods Enzymol. 291, 443–473]. Can compounds be found that compete with inhibitors for their binding site but do not change the channel-opening equilibrium? The systematic evolution of RNA ligands by exponential enrichment methodology and the AChR in Torpedo californica electroplax membranes were used to find RNAs that can displace inhibitors from the receptor. The selection of RNA ligands was carried out in two consecutive steps: (i) a gel-shift selection of high-affinity ligands bound to the AChR in the electroplax membrane, and (ii) subsequent use of nitrocellulose filters to which both the membrane-bound receptor and RNAs bind strongly, but from which the desired RNA can be displaced from the receptor by a high-affinity AChR inhibitor, phencyclidine. After nine selection rounds, two classes of RNA molecules that bind to the AChR with nanomolar affinities were isolated and sequenced. Both classes of RNA molecules are displaced by phencyclidine and cocaine from their binding site on the AChR. Class I molecules are potent inhibitors of AChR activity in BC3H1 muscle cells, as determined by using the whole-cell current-recording technique. Class II molecules, although competing with AChR inhibitors, do not affect receptor activity in this assay; such compounds or derivatives may be useful for alleviating the toxicity experienced by millions of addicts.