Defining the role of common variation in the genomic and biological architecture of adult human height

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated 1/42,000, 1/43,700 and 1/49,500 SNPs explained 1/421%, 1/424% and 1/429% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/I 2-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

New genetic loci link adipose and insulin biology to body fat distribution

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Speech of Mr. C. G. Memminger, on the question of rechartering the bank of the state of South Carolina: delivered in the House of Representatives, December 9, 1848

This speech by Mr. Memminger offers resolutions on the issue of rechartering the bank of the state of South Carolina. The issues presented are the Bank of the State is founded on an erroneous policy, unwise for a state to engage in banking, not practical to recharter the Bank of the State and a special committee of each house should be appointed to advise how to carry out these resolutions at the next session.

Speech delivered by Hon. Hermann Ridder at the one hundred and forty-second anniversary dinner, German Friendly Society, Charleston, S. C., January 15th, 1908

The speech was delivered to the German Friendly Society by the Hon. Hermann Ridder and opens with a brief history of the society and its importance. He then goes on to acknowledge notable German settlers and their importance. He calls for history to be rewritten and textbooks to be revised to give credit to the Germans who contributed to America’s foundation and history.

Iberismo, hispanismo e os seus contrários : Portugal e Espanha (1908-1931)

Tese de doutoramento, História (História Contemporânea), Universidade de Lisboa, Faculdade de Letras, 2016

Noon Recital, Joel Salsman, pianist, Music of Alan Hovhaness, February 11, 1966

Concert program for Noon Recital, Joel Salsman, pianist, Music of Alan Hovhaness, February 11, 1966

Nos bastidores da Corte. O Rei e a Casa Real na crise da Monarquia 1889-1908

Tese apresentada para cumprimentos dos requisitos necessários à obtenção do graus de Doutor em História, especialidade História Contemporânea

Post- och väg-karta öfver stor furstendömet Finland, med stöd af kartor utgifne af general landtmäteri contoiret, general staben, St Petersburgska postamtet, herrar Schubert, Ekelund, Brummer, von Knorring med flere och tillförlitligaste väga-uppgifter af alla storfurstendömets herrar gouverneurer samt enskilta bidrag utarbetad åren 1846 och 1848 af Berndt Ad. Lindeman postmästare

1 kartta :, vär. ;, 102 x 70 cm, [1:1231722], skalan är en million 231722 del af naturliga storleken

La Révolution française : revue historique...

1908/07 (T55)-1908/12.

La Révolution française : revue historique...

1908/01 (T54)-1908/06.

Revue cosmique (Paris)

Périodicité : Mensuel

Revue cosmique : publiée par un groupe d'étudiants inconnus et sincères / dir. F. Ch. Barlet

1908/07 (N7,A7).