972 resultados para Griffin, Sarah
Sarah Green: Notes from the Balkans. Locating Marginality and Ambiguity on the Greek-Albanian Border
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in populärer Form dargest. u. mit kurzen Erklärungen versehen von Ansbacher. Hrsg. vom "Württemberger gesetzestreuen Landesverband"
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The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.
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Fi
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Signatur des Originals: S 36/F00146
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Signatur des Originals: S 36/F03023
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Signatur des Originals: S 36/F03024
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Signatur des Originals: S 36/F03025
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Signatur des Originals: S 36/F03026
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Signatur des Originals: S 36/F03027
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Signatur des Originals: S 36/F03028
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Signatur des Originals: S 36/F03029
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Signatur des Originals: S 36/F03308
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Signatur des Originals: S 36/F03309
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Signatur des Originals: S 36/F03310
