964 resultados para Global optimization
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The conventional, grinding methods in some cases are not very efficient because the arising of thermal damages in the pieces is very common. Optimization methods of cutting fluid application in the grinding zone are essential to prevent thermal problems from interaction of the wheel grains with the workpiece. surface. The optimization can happen through the correct selection of the cut parameters and development of devices that eliminate air layer effects generated around the grinding wheel. This article will collaborate with the development of an experimentation methodology which allows evaluating, comparatively, the performance of the deflectors in the cutting region to minimize the air layer effect of the high speed of the grinding wheel. The air layers make the cutting fluid jet to dissipate in the machine. An optimized nozzle was used in order to compare the results with the conventional method (without baffles or deflectors) of cutting fluid application. The results showed the high eficciency of the deflectors or baffles in the finish results. Copyright © 2006 by ABCM.
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To enhance the global search ability of Population Based Incremental Learning (PBIL) methods, It Is proposed that multiple probability vectors are to be Included on available PBIL algorithms. As a result, the strategy for updating those probability vectors and the negative learning and mutation operators are redefined as reported. Numerical examples are reported to demonstrate the pros and cons of the newly Implemented algorithm. ©2006 IEEE.
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We introduce the notion of KKT-inverity for nonsmooth continuous-time nonlinear optimization problems and prove that this notion is a necessary and sufficient condition for every KKT solution to be a global optimal solution.
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Nowadays, we return to live a period of lunar exploration. China, Japan and India heavily invest in missions to the moon, and then try to implement manned bases on this satellite. These bases must be installed in polar regions due to the apparent existence of water. Therefore, the study of the feasibility of satellite constellations for navigation, control and communication recovers importance. The Moon's gravitational potential and resonant movements due to the proximity to Earth as the Kozai-Lidov resonance, must be considered in addition to other perturbations of lesser magnitude. The usual satellite constellations provide, as a basic feature, continuous and global coverage of the Earth. With this goal, they are designed for the smallest number of objects possible to perform a specific task and this amount is directly related to the altitude of the orbits and visual abilities of the members of the constellation. However the problem is different when the area to be covered is reduced to a given zone. The required number of space objects can be reduced. Furthermore, depending on the mission requirements it may be not necessary to provide continuous coverage. Taking into account the possibility of setting up a constellation that covers a specific region of the Moon on a non-continuous base, in this study we seek a criterion of optimization related to the time between visits. The propagation of the orbits of objects in the constellation in conjunction with the coverage constraints, provide information on the periods of time in which points of the surface are covered by a satellite, and time intervals in which they are not. So we minimize the time between visits considering several sets of possible constellations and using genetic algorithms.
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Feathers are rich in amino acids and can be employed as a dietary protein supplement for animal feed. Microbial degradation is an alternative technology for improving the nutritional value of feathers. Other potential applications of keratinase include use in the leather industry, detergents and medicine as well as the pharmaceutical for the treatment of acne, psoriasis and calluses. A new keratinolytic enzyme production bacterium was isolated from a poultry processing plant. To improve keratinase yield, statistically based experimental designs were applied to optimize three significant variables: temperature, substrate concentration (feathers) and agitation speed. Response surface methodology demonstrated an increase in keratinolytic activity at temperature, agitation speed and substrate concentration of 26.6°C, 150 rpm and 2%, respectively. Liquid chromatography revealed the release of amino acids in the Bacillus amyloliquefaciens culture broth, thereby demonstrating the potential of feather meal in the animal feed industry. © Global Science Publications.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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A self-learning simulated annealing algorithm is developed by combining the characteristics of simulated annealing and domain elimination methods. The algorithm is validated by using a standard mathematical function and by optimizing the end region of a practical power transformer. The numerical results show that the CPU time required by the proposed method is about one third of that using conventional simulated annealing algorithm.
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Considering the high competitivity in the market, the application of quantitative methods can assist in analyzing the efficiency of production facilities of areas of export and import processes of the chemical industry sector. In this sense, this work aims to apply the model GPDEA-BCC optimization in order to develop an analysis of the production units of this chemical industry. So, were chosen variables relevant to the process and elaborated a final comparison between the results obtained by the optimization tool and performance indexes provided by the company. These results indicated that some production units should be monitored more carefully because some of them had a low efficiency when analyzed with multi criteria
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Considering the high competitivity in the market, the application of quantitative methods can assist in analyzing the efficiency of production facilities of areas of export and import processes of the chemical industry sector. In this sense, this work aims to apply the model GPDEA-BCC optimization in order to develop an analysis of the production units of this chemical industry. So, were chosen variables relevant to the process and elaborated a final comparison between the results obtained by the optimization tool and performance indexes provided by the company. These results indicated that some production units should be monitored more carefully because some of them had a low efficiency when analyzed with multi criteria
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Background ArtinM is a D-mannose-specific lectin from Artocarpus integrifolia seeds that induces neutrophil migration and activation, degranulation of mast cells, acceleration of wound healing, induction of interleukin-12 production by macrophages and dendritic cells, and protective T helper 1 immune response against Leishmania major, Leishmania amazonensis and Paracoccidioides brasiliensis infections. Considering the important biological properties of ArtinM and its therapeutic applicability, this study was designed to produce high-level expression of active recombinant ArtinM (rArtinM) in Escherichia coli system. Results The ArtinM coding region was inserted in pET29a(+) vector and expressed in E. coli BL21(DE3)-Codon Plus-RP. The conditions for overexpression of soluble ArtinM were optimized testing different parameters: temperatures (20, 25, 30 or 37°C) and shaking speeds (130, 200 or 220 rpm) during induction, concentrations of the induction agent IPTG (0.01-4 mM) and periods of induction (1-19 h). BL21-CodonPlus(DE3)-RP cells induced under the optimized conditions (incubation at 20°C, at a shaking speed of 130 rpm, induction with 0.4 mM IPTG for 19 h) resulted in the accumulation of large amounts of soluble rArtinM. The culture provided 22.4 mg/L of rArtinM, which activity was determined by its one-step purification through affinity chromatography on immobilized D-mannose and glycoarray analysis. Gel filtration showed that rArtinM is monomeric, contrasting with the tetrameric form of the plant native protein (jArtinM). The analysis of intact rArtinM by mass spectrometry revealed a 16,099.5 Da molecular mass, and the peptide mass fingerprint and esi-cid-ms/ms of amino acid sequences of peptides from a tryptic digest covered 41% of the total ArtinM amino acid sequence. In addition, circular dichroism and fluorescence spectroscopy of rArtinM indicated that its global fold comprises β-sheet structure. Conclusions Overall, the optimized process to express rArtinM in E. coli provided high amounts of soluble, correctly folded and active recombinant protein, compatible with large scale production of the lectin.
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Nowadays the number of hip joints arthroplasty operations continues to increase because the elderly population is growing. Moreover, the global life expectancy is increasing and people adopt a more active way of life. For this reasons, the demand of implant revision operations is becoming more frequent. The operation procedure includes the surgical removal of the old implant and its substitution with a new one. Every time a new implant is inserted, it generates an alteration in the internal femur strain distribution, jeopardizing the remodeling process with the possibility of bone tissue loss. This is of major concern, particularly in the proximal Gruen zones, which are considered critical for implant stability and longevity. Today, different implant designs exist in the market; however there is not a clear understanding of which are the best implant design parameters to achieve mechanical optimal conditions. The aim of the study is to investigate the stress shielding effect generated by different implant design parameters on proximal femur, evaluating which ranges of those parameters lead to the most physiological conditions.
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The Gaussian-3 (G3) model chemistry method has been used to calculate the relative ΔG° values for all possible conformers of neutral clusters of water, (H2O)n, where n = 3−5. A complete 12-fold conformational search around each hydrogen bond produced 144, 1728, and 20 736 initial starting structures of the water trimer, tetramer, and pentamer. These structures were optimized with PM3, followed by HF/6-31G* optimization, and then with the G3 model chemistry. Only two trimers are present on the G3 potential energy hypersurface. We identified 5 tetramers and 10 pentamers on the potential energy and free-energy hypersurfaces at 298 K. None of these 17 structures were linear; all linear starting models folded into cyclic or three-dimensional structures. The cyclic pentamer is the most stable isomer at 298 K. On the basis of this and previous studies, we expect the cyclic tetramers and pentamers to be the most significant cyclic water clusters in the atmosphere.
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The technique of Abstract Interpretation has allowed the development of very sophisticated global program analyses which are at the same time provably correct and practical. We present in a tutorial fashion a novel program development framework which uses abstract interpretation as a fundamental tool. The framework uses modular, incremental abstract interpretation to obtain information about the program. This information is used to validate programs, to detect bugs with respect to partial specifications written using assertions (in the program itself and/or in system libraries), to generate and simplify run-time tests, and to perform high-level program transformations such as multiple abstract specialization, parallelization, and resource usage control, all in a provably correct way. In the case of validation and debugging, the assertions can refer to a variety of program points such as procedure entry, procedure exit, points within procedures, or global computations. The system can reason with much richer information than, for example, traditional types. This includes data structure shape (including pointer sharing), bounds on data structure sizes, and other operational variable instantiation properties, as well as procedure-level properties such as determinacy, termination, nonfailure, and bounds on resource consumption (time or space cost). CiaoPP, the preprocessor of the Ciao multi-paradigm programming system, which implements the described functionality, will be used to illustrate the fundamental ideas.
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This article focuses on the evaluation of a biometric technique based on the performance of an identifying gesture by holding a telephone with an embedded accelerometer in his/her hand. The acceleration signals obtained when users perform gestures are analyzed following a mathematical method based on global sequence alignment. In this article, eight different scores are proposed and evaluated in order to quantify the differences between gestures, obtaining an optimal EER result of 3.42% when analyzing a random set of 40 users of a database made up of 80 users with real attempts of falsification. Moreover, a temporal study of the technique is presented leeding to the need to update the template to adapt the manner in which users modify how they perform their identifying gesture over time. Six updating schemes have been assessed within a database of 22 users repeating their identifying gesture in 20 sessions over 4 months, concluding that the more often the template is updated the better and more stable performance the technique presents.